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Neferine2292-16-2

Name: Neferine2292-16-2
Brand: OORENT
SKU: pr2607083600
Price: 33 USD
Availability: InStock

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$33-34/MT FOB

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CAS No.:

2292-16-2

Grade:

Pharmaceutical Grade

Content:

99%

Port:

SHANGHAI

Brand:

OORENT

Packaging:

vial

Price valid (until):

2026-08-08

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Detail

Neferine Basic information

Product Name:	Neferine
Synonyms:	Phenol,4-[[(1S)-1,2,3,4-tetrahydro-6,7-diMethoxy-2-Methyl-1-isoquinolinyl]Methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-Methoxy-1-[(4-Methoxyphenyl)Methyl]-2-Methyl-7-isoquinolinyl]oxy]-;4-[[(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]-phenol;4-[(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl)methyl]-2-[[1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methylisoquinolin-7-yl]oxy]phenol;4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol;Neferin;NEFERINE;4''-O-Methylliensinine;Methylliensinine
CAS:	2292-16-2
MF:	C38H44N2O6
MW:	624.77
EINECS:
Product Categories:	reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;chemical reagent;pharmaceutical intermediate;phytochemical
Mol File:	2292-16-2.mol

Neferine Chemical Properties

Melting point	59-61 °C
Boiling point	710.9±60.0 °C(Predicted)
density	1.185±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: >15mg/mL
form	powder
pka	9.28±0.45(Predicted)
color	white to beige
Optical Rotation	[α]/D -34 to -44° (c=0 3. CHCl3)
InChIKey	MIBATSHDJRIUJK-ROJLCIKYSA-N
SMILES	C1(O)=CC=C(C[C@H]2C3=C(C=C(OC)C(OC)=C3)CCN2C)C=C1OC1=CC2=C(C=C1OC)CCN(C)[C@@H]2CC1=CC=C(OC)C=C1

Safety Information

WGK Germany	3
RTECS	SM9495000
Storage Class	11 - Combustible Solids

MSDS Information

Neferine Usage And Synthesis

Description	A bisbenzylisoquinoline alkaloid from Nelumbo nucifera, the structure of this base has been shown to be that represented above based upon chemical degrada_x0002_tive studies and spectroscopic data. Four methoxyl groups, one hydroxyl and two methylimino groups are present.
Chemical Properties	Extracted from the mature green germ of the Nymphaeaceae plant
Uses	Neferine is an isoquinoline alkaloid which enhances the antitumor effect of Mitomycin-C in hela cells through activation of p38-MAPK. Useful in the treatment of cervical cancers.
Definition	ChEBI: Neferine is a member of isoquinolines.
Biochem/physiol Actions	Neferine is a bis-benzylisoquinoline alkaloid isolated from the green seed embryos Nelumbo Nucifera Gaertn (Lotus) that displays multiple pharmacological activities including anti-tumor, antidepressant-like and antiarrhythmic actions. Recent studies shown that neferine potently inhibits proliferation of human osteosarcoma cells while is low-toxic on non-neoplastic human osteoblast cells. Apparently in U2OS cells, neferine stabilizes p21 through the activation of p38 MAPK, which leads to G1 cell cycle arrest. Also, neferine inhibits Ang II-induced HUVSMC proliferation by upregulation of HO-1.
in vivo	Neferine treatment at both low-dose (60 mg/kg/day by gavage) and high-dose (120 mg/kg/day by gavage) reduces the increment of collagen I, III and TGF-β1 protein expression induced by hyperglycemia^[2].
IC 50	p65; Autophagy
References	Yang, Chen.,J. Chin. Chem. Soc., 17,235 (1970)

Neferine Preparation Products And Raw materials

Pls input... Shop TRANS-2-DECEN-1-OL18409-18-2-Detailed Image 2

Basic Info

Product Name:

(-)-Neferine

Other Name:

Phenol,4-[[(1S)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]-;Neferine;4-[[(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]phenol;Neferin;4′′-O-Methylliensinine;Methylliensinine;(-)-Neferine

CAS No.:

2292-16-2

Molecular Formula:

C38H44N2O6

InChIKeys:

InChIKey=MIBATSHDJRIUJK-ZWXJPIIXSA-N

Molecular Weight:

624.77

Exact Mass:

624.77

DSSTox ID:

DTXSID40177462

Categories:

Chinese Herbs

Characteristics

PSA:

72.9

XLogP3:

5.49

Appearance:

white to beige

Density:

1.2±0.1 g/cm3

Melting Point:

59-61 °C

Boiling Point:

710.9±60.0 °C at 760 mmHg

Flash Point:

383.8±32.9 °C

Refractive Index:

1.601

Water Solubility:

DMSO: >15mg/mL

Storage Conditions:

2-8°C

Vapor Pressure:

6.97E-21mmHg at 25°C

See More (-)-Neferine Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More (-)-Neferine Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
South Korea	(-)-Neferine	1 KG	Jul 8, 2026

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