β-Mangostin,20931-37-7

• English Name: Beta‑mangostin

• CAS Number: 20931‑37‑7

• Molecular Formula: C₂₅H₂₈O₆

• Molecular Weight: 424.5 g/mol

• Appearance: Yellow solid or powder

• Melting Point: 175–176 °C

• Boiling Point (predicted): 616.5 ± 55 °C

• Density: 1.212 g/cm³

• pKa (predicted): 7.05 ± 0.20

• UV‑Vis λmax: 244, 259, 316 nm

• Storage Conditions: 2–8 °C, protected from light (light‑sensitive)

Chemical Uses and Biological Activities

1. Antibacterial Activity (including drug‑resistant strains)

• Shows strong inhibitory activity against MRSA and MSSA

• MIC typically ranges from 6.25–25 μg/mL

2. Antimalarial Activity

• Effective against Plasmodium falciparum

• IC₅₀ ≈ 3 μg/mL

3. Antituberculosis Activity

• Inhibits Mycobacterium tuberculosis

• MIC ≈ 6.25 μg/mL

4. Antitumor Activity

• Inhibits fatty acid synthase (FASN)

  • IC₅₀ ≈ 24.83 μM

• Induces G₂/M cell‑cycle arrest and mitochondria‑mediated apoptosis in MCF‑7 breast cancer cells

• Demonstrates inhibitory effects on hepatocellular carcinoma, leukemia, and other tumor cell lines

5. Anti‑inflammatory Activity

• Suppresses production of NO and PGE₂ in RAW264.7 macrophages

• Reduces TNF‑α, IL‑1β, and neutrophil infiltration in mouse inflammation models

6. Natural Product Source

• Belongs to the xanthone class of natural compounds

• Primarily isolated from the pericarp of Garcinia mangostana (mangosteen) and other Clusiaceae plants