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Acetyl chloride hly57 cas no 75-36-5

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CAS No.:

75-36-5

Grade:

Industrial Grade

Content:

99.5%

Port:

qingdao

Brand:

HLY

Packaging:

180kg per 200L galvanized steel drum

Price valid (until):

2027-02-28

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Suqian City Hengliyuan Import and Export Trade Co., LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Acrylonitrile,Sodium biselenite methylamine solution,Methylamine [anhydrous],Zinc dust,Hydrogen peroxide solution [content >8%],Triisopropyl borate

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Product Description
Seller Information
Inquiry History

Description

Company Profile ----------
Suqian City Hengliyuan Import and Export Trade Co., LTD is a trading company. The company has introduced advanced scientific and technological achievements from home and abroad, and has superior products from well-known manufacturers at home and abroad. The basic functions are:
1. Domestic trade of various chemical raw materials;
2. Providing price information services and chemical raw material procurement for industrial enterprises;
3. Cooperating with Chinese state-owned enterprise factories, the price and quality are very advantageous.
At present, the company is relying on the combination of industry and trade and global procurement to steadily improve the company's value-added ability and compound competitiveness. We have always been committed to producing high-quality and low-cost goods, so we have been sincerely recognized by many customers. Our goal is to produce the best products and satisfy every customer with professional services and attitudes. We look forward to cooperating with you and establishing a win-win relationship with you. Please rest assured that we will definitely satisfy you.

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----------Our Advantages---------
High quality with competitive price
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We can provide high quality products with factory price
2. Fast delivery
1) Fast shipment.Various transportation methods for your choice.
2) We have our own agent/remailer/distributor who can help us ship our products very fast , and we have stock in the ir for transferring.
3. Good communication and credit
1) Fast response to customer within 5 hours
2) Good business credit in Europe, US, Japan, Korea, Af r ica and so on.

Acetyl Chloride

1. Basic Identification

CAS No.: 75-36-5

Chemical Name: Acetyl Chloride

IUPAC Name: Ethanoyl chloride

Synonyms: Ethanoyl chloride, Acetic chloride, Acetic acid chloride

EINECS No.: 200-928-5

Molecular Formula: $\mathbf{C_2H_3ClO}$

Structural Formula: $\mathbf{CH_3COCl}$

Molecular Weight: 78.50

SMILES: CC(=O)Cl

UN Number: UN 1717

HS Code: 29151200

Hazard Classification: Class 3 Flammable Liquid + Class 8 Corrosive Substance, Packing Group II

Chemical Category: Low-boiling acyl chloride, high-activity acylation reagent, core fine chemical intermediate

2. Physical & Chemical Properties

Appearance

Colorless transparent volatile liquid, emits dense white corrosive smoke in humid air with sharp pungent irritating odor.

Physical Constants

Parameter	Standard Value	Remarks
Melting Point	-112 ℃	Low freezing point, always liquid under normal storage
Boiling Point	50–52 ℃ (760 mmHg)	Extremely low boiling point, highly volatile
Density (20 ℃)	1.104–1.106 g/mL	Heavier than water
Refractive Index $n_{20/D}$	1.388–1.390
Closed Cup Flash Point	4 ℃	Extremely flammable liquid
Autoignition Temperature	390 ℃
Explosion Limit in Air (V/V)	3.2% ~ 18.5%	Very wide explosive range, high fire risk
Vapor Pressure (20 ℃)	32 kPa	Strong volatility, toxic corrosive vapor easily spreads
Water Reaction	Violent exothermic hydrolysis immediately upon contact	$\ce{CH3COCl + H2O -> CH3COOH + HCl ^}$
Organic Solvent Solubility	Fully miscible with anhydrous toluene, xylene, chloroform, ethyl acetate, acetone, anhydrous ether; strictly incompatible with alcohols, amines, water-containing solvents

Core Chemical Characteristics

Ultra-active acyl chloride functional group (-COCl), typical acylation reagent:
- React with alcohols → acetate ester + HCl
- React with primary/secondary amines → acetamide derivatives
- React with aromatic rings (Friedel-Crafts) → aromatic ketones
- React with carboxylic acids → acid anhydrides
Severe hydrolysis: Even trace moisture triggers violent reaction releasing heat and hydrogen chloride fumes; must be stored under fully anhydrous and nitrogen-sealed conditions.
Incompatible with all protic substances (water, alcohol, amine, acid, alkali); mixing will release a large amount of heat and corrosive gas, risk of splashing and explosion.
Light and heat sensitive; long-term exposure to air leads to decomposition and discoloration, requires light-proof low-temperature sealed storage.
Strong corrosive and irritant: Vapor severely burns respiratory tract, eyes and mucous membranes; liquid causes blistering irreversible chemical burns to skin.

3. Export Industrial Quality Standard (Premium Grade ≥99.0%)

Test Item	Standard Spec	Test Method
Acetyl Chloride Assay	≥99.0 %	GC Gas Chromatography
Residual Acetic Acid	≤0.30 %	GC / Potentiometric titration
Free Hydrogen Chloride	≤0.20 %	Acid-base titration
Moisture Content	≤50 ppm	Karl Fischer Titration (anhydrous testing environment)
Color (APHA)	≤15	Platinum-Cobalt Colorimetry
Distillation Range (49–53 ℃)	≥95 vol%	Atmospheric distillation test
Appearance	Colorless clear fuming liquid without turbidity or sediment	Visual Inspection

High-Purity Pharmaceutical Grade (≥99.5%)

Ultra-low acid and HCl impurities, moisture <20 ppm, vacuum nitrogen-sealed packaging, dedicated to amino acid protection and heterocyclic API synthesis.

4. Main Industrial Applications

4.1 Pharmaceutical & Peptide Synthesis (High-value Core Field)

Acylation protecting reagent for amino groups in solid-phase peptide synthesis; prepare acetyl-protected amino acid fragments.
Key intermediate for synthesis of antibiotics, anti-inflammatory drugs, cardiovascular heterocyclic APIs, steroid medicines.
Raw material for acetamide, acetyl heterocyclic drug skeletons via reaction with amines and aromatic substrates.

4. Agrochemical Intermediates

Manufacture of acetamide herbicides, fungicides and insecticides; acetyl modification improves compound lipophilicity and crop absorption efficiency.
Synthesis of pesticide synergists and plant growth regulator intermediates.

4.2 Dye & Fine Chemical Industry

Friedel-Crafts acylation raw material for aromatic ketone dyes, disperse dyes and fluorescent pigments.
Acetylation modifier for textile finishing auxiliaries and fluorescent whitening agents.

4.3 Polymer & Coating Raw Material

Acylation crosslinking agent for polyurethane and polyester resin; introduce acetyl segments to adjust coating flexibility and adhesion.
Raw material for blocked isocyanate and single-component baking paint curing agents.

4.4 Laboratory Organic Synthesis Reagent

Universal high-activity acylation reagent for selective modification of hydroxyl and amino groups; widely used in total synthesis of complex natural products.

5. Safety, Packaging, Storage & Transportation Regulations

GHS Hazard Classification

Signal Word: Danger

Hazard Statements:

H224 Extremely flammable liquid and vapor

H314 Causes severe skin burns and eye damage

H330 Fatal if inhaled

H260 In contact with water releases flammable, corrosive gases which may ignite spontaneously

Export Standard Packaging (Strictly Anhydrous Nitrogen Sealed)

Industrial bulk grade: 200L anti-corrosion lined steel drum, vacuum nitrogen filling inner seal with PTFE anti-corrosion gasket
Medium batch: 25L plastic-lined iron drum
Pharmaceutical high-purity grade: Light-proof aluminum foil inner bag + iron drum, low-moisture barrier packaging
Trial order: 1L / 5L brown sealed pressure-resistant glass bottle with anti-leak outer barrel

Mandatory Storage Requirements

Independent Class A flammable corrosive chemical warehouse, temperature controlled ≤25 ℃, full explosion-proof negative pressure ventilation system.
Fully nitrogen sealed to isolate moisture and air; completely separated from water, alcohols, amines, edible raw materials, oxidants and strong acids.
Warehouse equipped with hydrogen chloride gas leakage detector, full gas-proof respirators, acid-resistant PPE and emergency eyewash station; water-based fire extinguishers are forbidden, only dry powder / CO₂ fire extinguishers can be used.
Shelf life: 6 months under low-temperature nitrogen sealed storage; re-test purity once expired, discard if turbidity appears due to hydrolysis.

Transportation Rules

UN 1717, Dual hazard: Class 3 Flammable Liquid + Class 8 Corrosive Goods, Packing Group II

All packages must be fully waterproof and light-proof; loading/unloading is prohibited in rainy and humid environments to prevent drum leakage and contact with moisture.
Strictly no mixed loading with water-containing chemicals, alcohols, amines, oxidants and food additives in one container.
Avoid direct sunlight and high-temperature stacking during transit; all transport vehicles must be explosion-proof with static grounding.
Complete export clearance documents: COA, MSDS, TDS, IMDG marine dangerous goods declaration, hazard classification certificate.

6. E-commerce Listing Copy (Directly Used for Alibaba / Echemi)

Title

Acetyl Chloride Ethanoyl Chloride CAS 75-36-5 99% Colorless Fuming Liquid High Activity Acylation Reagent for Pharmaceutical Peptide Agrochemical Dye Friedel-Crafts Reaction

Short Description

Acetyl Chloride (C₂H₃ClO, CAS 75-36-5) ≥99% anhydrous high-activity acyl chloride fuming liquid, extremely sensitive to moisture. Widely used as core acylation intermediate for solid-phase peptide synthesis, heterocyclic pharmaceutical APIs, acetamide herbicides and aromatic ketone dye production. Full set of dangerous goods export documents including COA, MSDS and TDS available for global bulk shipment.

Full Description

Acetyl Chloride (Ethanoyl chloride, CAS 75-36-5) is a high-reactivity low-boiling acyl chloride supplied as colorless volatile fuming liquid with GC purity ≥99.0%. Its active -COCl group can quantitatively react with hydroxyl, amino and aromatic rings to synthesize ester, amide and aromatic ketone derivatives, an indispensable building block in fine chemical manufacturing.

Main downstream application sectors cover high-end pharmaceutical raw material and peptide amino-protecting reagent; agrochemical acetamide fungicide & herbicide intermediate; aromatic ketone dye and fluorescent whitening agent synthesis; laboratory Friedel-Crafts acylation standard reagent. We supply standard industrial grade and ultra-high purity pharmaceutical special grade with ultra-low moisture and acid impurities, packed under nitrogen to avoid hydrolysis during long sea transportation.

All products adopt nitrogen-sealed anti-corrosion lined steel drums for full container shipment. Classified as UN1717 dual-hazard dangerous goods (flammable & corrosive), we provide complete official customs clearance certification documents to support global sea and land delivery with stable continuous supply capacity.

7. Printable Export COA Template

CERTIFICATE OF ANALYSIS

Product Name: Acetyl Chloride

CAS No.: 75-36-5

Grade: Export Premium Industrial Grade

Batch No.: ____________

Net Weight: 200kg/drum

Manufacture Date: ____________

Test Item	Standard Spec	Test Result	Test Method
Acetyl Chloride Assay Purity	≥99.0 %		GC Gas Chromatography
Residual Acetic Acid	≤0.30 %		GC Titration
Free Hydrogen Chloride	≤0.20 %		Acid-Base Titration
Moisture Content	≤50 ppm		Karl Fischer Titration
Color (APHA)	≤15		Platinum-Cobalt Colorimetry
Distillation Range (49–53℃)	≥95 vol%		Atmospheric Distillation
Appearance	Colorless clear fuming liquid without turbidity or sediment	Visual Inspection

Conclusion: This batch meets premium export industrial standard of Acetyl Chloride.

Inspector Signature: ____________

Testing Date: ____________

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Certificates

Basic Info

Product Name:

Acetyl chloride

Other Name:

Acetyl chloride;Ethanoyl chloride;Acetic chloride;Acetic acid chloride

CAS No.:

75-36-5

Molecular Formula:

C2H3ClO

InChIKeys:

InChIKey=WETWJCDKMRHUPV-UHFFFAOYSA-N

Molecular Weight:

78.5

Exact Mass:

78.50

BRN:

605303

EC Number:

200-865-6

UNII:

QD15RNO45K

ICSC Number:

0210

UN Number:

1717

DSSTox ID:

DTXSID2023852

Color/Form:

Liquid|Colorless fuming liquid

HScode:

2915900090

Categories:

Pesticide Intermediates

Characteristics

PSA:

17.1

XLogP3:

-0.47

Appearance:

Clear colorless Liquid

Density:

1.1051 g/cm³ @ Temp: 20 °C

Melting Point:

-112 °C

Boiling Point:

52 °C

Flash Point:

40 °F

Refractive Index:

1.379

Water Solubility:

Miscible with acetone, chloroform, glacial acetic acid, petroleum ether, ether and benzene.

Storage Conditions:

Store at RT

Vapor Pressure:

11.69 psi ( 20 °C)

Vapor Density:

2.7 (vs air)

Toxicity:

Oral-Rat LD50: 910 mg/kg

Flammability characteristics:

Inflammable in case of fire, high temperature and oxidant; decomposes toxic phosgene in high heat; emits toxic chloride fumes in water

Explosive limit:

7.3-19%(V)

Odor:

Pungent odor

OH:

9.10e-15 cm3/molecule*sec

Experimental Properties:

Decomposed violently by water or alcohol|Highly refractive|Ratio of specific heats of vapor (gas): 1.1467|Liquid heat capacity: 0.350 Btu/lb-F at 70 °F|For more Other Experimental Properties (Complete) data for Acetyl chloride (8 total), please visit the HSDB record page.

Air and Water Reactions:

Highly flammable. Fumes in air. Reacts violently with water producing heat and acidic HCl [Merck 11th ed. 1989]. Acetyl chloride reacts vigorously with water to generate gaseous HCl. Based on a scenario where the chemical is spilled into an excess of water (at least 5 fold excess of water), half of the maximum theoretical yield of Hydrogen Chloride gas will be created in 0.11 minutes. Experimental details are in the following: "Development of the Table of Initial Isolation and Protective Distances for the 2008 Emergency Response Guidebook", ANL/DIS-09-2, D.F. Brown, H.M. Hartmann, W.A. Freeman, and W.D. Haney, Argonne National Laboratory, Argonne, Illinois, June 2009.

Reactive Group:

Acyl Halides, Sulfonyl Halides, and Chloroformates

Reactivity Alerts:

Highly Flammable

Reactivity Profile:

ACETYL CHLORIDE reacts violently with water, steam, methanol or ethanol to form hydrogen chloride and acetic acid. Reacts vigorously with bases, both organic and inorganic. Incompatible with oxidizing agents and alcohols. Produces highly toxic fumes of phosgene gas and chlorine when heated to decomposition [Sax, 9th ed., 1996, p. 35]. Reaction in a confined space with even a small amount of water may cause a violent eruption of gases [Bretherick, 5th ed., 1995, p. 281]. Vapor forms an explosive mixture with air [Kirk-Othmer, 3rd ed., Vol. 1, 1978, p. 162]. Polymerization reaction with dimethyl sulfoxide is particularly violent [Buckley, A., J. Chem. Ed., 1965, 42, p. 674]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Autoignition Temperature:

734 °F (USCG, 1999)|734 °F (390 °C)|390 °C

Heat of Combustion:

-6,000 btu/lb = -3,000 cal/g = -140X10X5 J/kg

Flammable Limits:

Lower: 5.0% by volume

Physical Dangers:

The vapour is heavier than air and may travel along the ground; distant ignition possible.

Corrosivity:

Corrosive|Corrosive to metals and tissue

Heat of Vaporization:

160 btu/Lb = 88 cal/g = 3.7X10X5 J/kg

Critical Temperature & Pressure:

Critical temperature: 475 °F = 246 °C = 519 deg K; Critical pressure: 845 psia = 57.5 atm = 5.83 MN/sq m

See More Acetyl chloride Properties 

Hazard Identification

Classification of the substance or mixture

Flammable liquids, Category 2

Skin corrosion, Sub-category 1B

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H225 Highly flammable liquid and vapour H314 Causes severe skin burns and eye damage
Prevention	P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray. P264 Wash ... thoroughly after handling.
Response	P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P316 Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage	P403+P235 Store in a well-ventilated place. Keep cool. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames, NO sparks and NO smoking. NO contact with hot surfaces. Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent build-up of electrostatic charges (e.g., by grounding). Do NOT use compressed air for filling, discharging, or handling. Use non-sparking handtools. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Fireproof. Separated from incompatible materials. See Chemical Dangers. Dry. Well closed.Separate from alcohols, alkalies, amines, and strong oxidizing materials. Store in a cool, dry well-ventilated location. Outside or detached storage is preferred. Inside storage should be in a standard flammable liquids storage warehouse, room, or cabinet.

See More Acetyl chloride Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Acrylonitrile,Sodium biselenite methylamine solution,Methylamine [anhydrous],Zinc dust,Hydrogen peroxide solution [content >8%],Triisopropyl borate

Location:
Shop No.15, 1st Floor, Building 12, Hengda Huafu, Sucheng District, Suqian City

Payment Terms:
TT against B/L draft before shipment,100% TT in advance

Average lead Time:
30

Total Annual Revenue:
Less than $1 million

Total Employees:
5-10

Year of Establishment:
2022
Company Overview

Suqian Hengliyuan Import and Export Corporation, Ltd. is a leading enterprise specializing in the international trade of chemical products. Established in Suqian, Jiangsu Province, China, our company has built a strong reputation for excellence and reliability in the chemical industry.

Our Mission

Our mission is to facilitate global trade by providing high-quality chemical products and exceptional service to our clients. We aim to be a bridge between manufacturers and end-users, ensuring the safe and efficient transfer of chemicals across borders.

Products and Services

We offer a comprehensive range of chemical products, including but not limited to:

Industrial Chemicals: Raw materials for various industries such as pharmaceuticals, agriculture, and manufacturing.

Specialty Chemicals: High-performance chemicals used in specific applications, including water treatment, coatings, and adhesives.

Bulk Chemicals: Large-volume chemicals for industrial processes and manufacturing needs.

Quality Assurance

At Suqian Hengliyuan Import and Export Corporation, Ltd., quality is our top priority. We adhere to stringent quality control measures and international standards to ensure that our products meet the highest levels of purity and performance. Our dedicated quality assurance team conducts rigorous inspections and testing to guarantee the integrity and safety of all our chemical products.

Global Network

Leveraging our extensive network of suppliers and partners, we are able to source and deliver a wide array of chemical products to clients worldwide. Our strategic partnerships and logistical expertise enable us to offer competitive pricing, timely delivery, and customized solutions to meet the diverse needs of our clients.

Commitment to Sustainability

We are committed to sustainable business practices and environmental stewardship. Our operations are designed to minimize environmental impact, and we continuously seek ways to improve our processes and reduce our carbon footprint. We work closely with our suppliers and customers to promote the responsible use and disposal of chemicals.

Customer Focus

Our clients are at the heart of everything we do. We pride ourselves on providing personalized service and building long-term relationships based on trust and mutual benefit. Our experienced team of professionals is dedicated to understanding our clients' needs and delivering solutions that exceed their expectations.

Inquiry History

4 Inquiries

Country	Product	Purchase Quantity	Date Posted
Thailand	Acetyl chloride	200 KG	Oct 11, 2023
Canada	Acetyl chloride	100 G	Jun 15, 2026
Bangladesh	Hot selling high quality paracetamol 99% white powder 103-90-2 Ainuodi	70 MT	Oct 20, 2023
Romania	Hot selling high quality paracetamol 99% white powder 103-90-2 Ainuodi	10000 MT	Aug 28, 2023

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