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Suqian City Hengliyuan Import and Export Trade Co., LTD is a trading company. The company has introduced advanced scientific and technological achievements from home and abroad, and has superior products from well-known manufacturers at home and abroad. The basic functions are:
1. Domestic trade of various chemical raw materials;
2. Providing price information services and chemical raw material procurement for industrial enterprises;
3. Cooperating with Chinese state-owned enterprise factories, the price and quality are very advantageous.
At present, the company is relying on the combination of industry and trade and global procurement to steadily improve the company's value-added ability and compound competitiveness. We have always been committed to producing high-quality and low-cost goods, so we have been sincerely recognized by many customers. Our goal is to produce the best products and satisfy every customer with professional services and attitudes. We look forward to cooperating with you and establishing a win-win relationship with you. Please rest assured that we will definitely satisfy you.
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High quality with competitive price
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We can provide high quality products with factory price
2. Fast delivery
1) Fast shipment.Various transportation methods for your choice.
2) We have our own agent/remailer/distributor who can help us ship our products very fast , and we have stock in the ir for transferring.
3. Good communication and credit
1) Fast response to customer within 5 hours
2) Good business credit in Europe, US, Japan, Korea, Af r ica and so on.
Complete Product Details – 3-Nitrobenzyl Chloride (CAS 619-23-8)
1. Basic Identification Information
CAS No.: 619-23-8
Chemical Name: 3-Nitrobenzyl Chloride
Synonyms: m-Nitrobenzyl Chloride, 1-(Chloromethyl)-3-nitrobenzene
EINECS No.: 210-586-1
MDL No.: MFCD00007272
Molecular Formula: C₇H₆ClNO₂
Molecular Weight: 171.58
SMILES: ClCc1cccc(
N+[O-])c1
UN Number: UN 3261
HS Code: 2904990090
Hazard Classification: Class 8 Corrosive Substance, Packing Group II
Chemical Category: Aromatic benzyl halide, high-activity alkylation intermediate, protecting group reagent for peptide & API synthesis
2. Physical & Chemical Properties
2.1 Appearance
Light yellow to pale orange crystalline solid; slight irritant odor; moisture-sensitive, easy to agglomerate and release hydrogen chloride gas when exposed to humid air.
2.2 Core Physical Constants
| Parameter | Standard Value |
| Melting Point | 43–47 °C (Premium grade ≥45 °C) |
| Boiling Point | 173–183 °C (760 mmHg); 85–87 °C / 5 mmHg |
| Density (Solid) | 1.503 g/cm³ |
| Closed Cup Flash Point | >110 °C |
| Water Solubility | <0.1 g/100 mL at 22 °C, practically insoluble in water |
| Solubility in Organics | Soluble in methanol, ethanol, chloroform, dichloromethane, toluene, DMF, acetone |
| Storage Temperature | ≤25 °C, sealed under nitrogen to avoid moisture |
2.3 Key Chemical Characteristics
- Strong alkylating reactivity: Benzylic chlorine is highly active; undergoes SN2 substitution with amines, alcohols, carboxylic acids, thiols to generate benzyl-protected derivatives.
- Severe hydrolysis with moisture/water: Reacts rapidly to produce 3-nitrobenzyl alcohol and corrosive HCl fumes, losing activity and caking.
- Nitro group on meta-position enables subsequent reduction to amino group (-NH₂), a key step for heterocyclic drug synthesis.
- Corrosive to metal, skin and eye mucosa; incompatible with water, alcohols, strong bases, ammonia, oxidizing agents.
- Thermally stable under sealed anhydrous storage; discolors to dark brown under long-term light exposure.
3. Industrial Export Quality Specifications
Premium Industrial Grade (GC ≥98.0%, mainstream export)
| Test Item | Standard Spec | Test Method |
| 3-Nitrobenzyl Chloride Purity | ≥98.0 % | Gas Chromatography GC |
| Free 3-Nitrobenzyl Alcohol Impurity | ≤1.0 % | GC / HPLC |
| Moisture Content | ≤0.50 % | Karl Fischer Titration |
| Melting Point Range | 43–47 °C | Melting Point Apparatus |
| Single Unknown Organic Impurity | ≤0.30 % | GC |
| Color of Crystal | Light yellow uniform crystal, no black agglomerates | Visual Inspection |
High Purity Pharma Grade (GC ≥99.0%)
Ultra-low moisture (<0.1%), trace heavy metals (Pb, As <1 ppm), strictly anhydrous, customized for peptide solid-phase synthesis and high-end APIs.
4. Main Industrial Applications
4.1 Pharmaceutical & Peptide Synthesis (Core High-value Application)
- Orthogonal protecting group reagent for amino acid side chains in solid-phase peptide synthesis; 3-nitrobenzyl group is cleavable under UV irradiation without damaging peptide backbones.
- Key alkylation intermediate for cardiovascular, anti-inflammatory, antibacterial APIs; introduces benzyl side chain via substitution reaction.
- Precursor of m-aminobenzyl alcohol after nitro reduction, raw material for nitrogen-containing heterocyclic drug skeletons.
- Intermediate for cephalosporin, penicillin side chain modification and chiral drug resolution.
4.2 Agrochemical Intermediates
- Synthesis of benzyl amide fungicides, herbicides and plant growth regulators; improves compound lipophilicity and biological activity.
- Raw material for pesticide emulsifier and heterocyclic insecticide manufacturing.
4.3 Fine Chemical & Dye Industry
- Intermediate for azo dyes, fluorescent whitening agents and photo-sensitive color developers; the nitro group provides chromophore precursor after reduction.
- Capping reagent for polyamine resin and water-soluble polymer modification.
4.4 Laboratory Organic Synthesis Reagent
Universal benzylation reagent for carboxylic acids, thiols and amines; widely used for hydroxyl/amino group protection in multi-step organic total synthesis.
5. Safety, Packaging, Storage & Transportation Rules
5.1 GHS Hazard Classification
- Skin Corrosion Category 1B, Serious Eye Damage Category 1
- Acute Inhalation Toxicity Category 4
Signal Word: Danger
Main Hazard Statements:
H314 Causes severe skin burns and eye damage
H332 Harmful if inhaled
H290 May be corrosive to metals
H260 Reacts violently with water releasing corrosive hydrogen chloride gas
5.2 Export Standard Packaging
- Industrial bulk crystal: 25kg plastic-lined sealed iron drum, nitrogen-filled inner seal to isolate moisture
- Small trial packaging: 5kg / 1kg moisture-proof metal can
- Pharma high-purity grade: Vacuum-sealed aluminum foil bag inside iron drum
5.3 Storage Requirements
- Store in independent cool, dry, airtight corrosive chemical warehouse, temperature ≤25 °C; strictly block rain, moisture and humid air.
- Separate storage away from water, alcohols, amines, strong acids, strong alkalis, oxidants and food raw materials.
- Warehouse equipped with negative pressure ventilation, HCl gas alarm, acid-resistant PPE and dry powder fire extinguisher (water forbidden for fire fighting).
- Shelf life: 12 months under sealed nitrogen protection; re-test purity if stored over shelf life.
5.4 Sea & Land Transportation Regulation
UN 3261, Class 8 Corrosive Dangerous Goods, Packing Group II
- Full waterproof protection during transit; prohibit loading/unloading under rainy/humid weather.
- Strictly forbidden to mix load with aqueous chemicals, alcohol, amine, oxidants and edible additives in one container.
- Complete export clearance documents supplied: COA, MSDS, TDS, hazardous goods identification certificate, marine dangerous goods declaration.
6. E-commerce Listing Copy (Direct Copy for Echemi / Alibaba)
Product Title
3-Nitrobenzyl Chloride m-Nitrobenzyl Chloride CAS 619-23-8 98% Yellow Crystal Alkylation Intermediate for Pharmaceutical API Peptide Synthesis Agrochemical
Short Description
3-Nitrobenzyl Chloride (C7H6ClNO2, CAS 619-23-8) ≥98% light yellow aromatic benzyl halide crystal, high-efficiency alkylating & protecting group reagent. Widely used as core intermediate for pharmaceutical APIs, solid-phase peptide synthesis, agrochemical fungicides and fine dye manufacturing. Full set of export hazardous documents including COA, MSDS and TDS available for global bulk shipment.
Full Listing Description
3-Nitrobenzyl Chloride (also named m-Nitrobenzyl Chloride) with CAS registry number 619-23-8 is a premium aromatic benzyl chloride supplied as uniform pale yellow crystal complying with industrial GC purity standard ≥98%. It features ultra-active benzylic chlorine for substitution reactions and reducible meta-nitro functional group, irreplaceable in multi-step fine organic synthesis.
This chemical covers multiple high-value downstream industries: pharmaceutical raw material & peptide synthesis as UV-cleavable protecting group; heterocyclic antibiotic and cardiovascular drug intermediate; agrochemical amide pesticide manufacturing; fluorescent dye and photosensitive material precursor and lab universal benzylation reagent. We also supply 99.0% anhydrous pharmaceutical special grade with ultra-low moisture and heavy metal impurities for high-end fine synthesis.
Products are packed in nitrogen-sealed moisture-proof lined iron drums for full container shipment. Classified as UN3261 Class 8 corrosive dangerous goods, we provide complete official customs clearance papers to support global sea and land delivery with stable continuous supply capacity worldwide.
7. Printable Export Certificate of Analysis Template
CERTIFICATE OF ANALYSIS
Product Name: 3-Nitrobenzyl Chloride Crystal
CAS No.: 619-23-8
Grade: Export Premium Industrial Grade
Net Weight: 25kg/drum
| Test Item | Standard Spec | Test Result | Test Method |
| 3-Nitrobenzyl Chloride Assay Purity | ≥98.0 % |
| GC Gas Chromatography |
| Free 3-Nitrobenzyl Alcohol | ≤1.0 % |
| GC / HPLC |
| Moisture Content | ≤0.50 % |
| Karl Fischer Titration |
| Melting Point Range | 43–47 °C |
| Melting Point Tester |
| Single Organic Impurity | ≤0.30 % |
| GC |
| Appearance | Light yellow uniform crystal without black caking | Visual Inspection |
|
Conclusion: This batch meets premium export standard of 3-Nitrobenzyl Chloride.
TDS
