Product Overview
LL-37 is the only known active peptide belonging to the Cathelicidin family of antimicrobial peptides in the human body. It plays a crucial role as the "first line of defense" in the human innate immune system.
1. Origin and Structure of LL-37
Name Origin : It consists of 37 amino acids and starts with two Leucine (L) residues at the N-terminus, hence the name LL-37.
Production Mechanism : LL-37 is cleaved and released from its precursor protein, hCAP18, by specific enzymes (such as Proteinase 3).
Structural Features : Under physiological conditions, LL-37 typically adopts an $\alpha$-helical structure, which allows it to readily interact with microbial cell membranes.
2. Main Biological Functions
LL-37 is not just a "natural antibiotic"; it also exhibits multiple immunomodulatory actions:
Antimicrobial Activity
Membrane Disruption: Carrying a net positive charge, LL-37 binds to negatively charged bacterial cell membranes, inserting into and permeabilizing the membrane, which leads to bacterial cell lysis and death.
Broad-Spectrum Antibacterial Effect: It shows inhibitory and bactericidal effects against Gram-positive bacteria, Gram-negative bacteria, fungi, and certain enveloped viruses.
Immunomodulation ("Dual-Action Regulator")
Endotoxin Neutralization: It binds to lipopolysaccharide (LPS/endotoxin) released by Gram-negative bacteria, preventing hyper-inflammatory responses (cytokine storms) in the immune system.
Immune Cell Recruitment: It acts as a chemoattractant, recruiting neutrophils, monocytes, and T cells to sites of infection or tissue damage.
Wound Healing and Angiogenesis
Tissue Repair: LL-37 stimulates the proliferation and migration of epithelial cells and fibroblasts, accelerating wound closure.
Vascular Formation: It promotes the growth of new blood vessels, providing nutritional support for tissue repair.
Q&A
Q: When can I receive the package?
A: It will be shipped as soon as possible after payment, and the shipping time is generally 7 to 15 days.
Q: What is the minimum amount I can order?
A: The minimum quantity we can order is 1 box, which contains 10 vials.
Q:How about the price? Can you make it cheaper?
A:We always take the customer's benefit as the top priority. Price is negotiable under different conditions, we are assuring you to get the most competitive price.
Q: How do i keep the peptides when i receive it ?
A: Peptides in the form of lyophilized powder can be transported at room temperature by vacuum packaging, while polypeptides in the dissolved state need to be refrigerated at 2°C - 8°C. For long-term storage, peptides should be stored in the form of lyophilized powder store at -20°C or -80°C in a sealed container with desiccant, which can avoid the degradation of peptides to the greatest extent.
Company Profile
HKX is a reliable manufacturer and exporter of peptide raw materials.
We have strong R&D capabilities and advanced production facilities. Our products cover various synthetic peptides and related raw materials, which are widely used in scientific research and pharmaceutical development. Every batch of goods undergoes rigorous laboratory testing to meet international quality standards.
We have years of international trade experience and a complete logistics system. Neutral packaging is used for all goods to comply with international shipping regulations. We provide flexible order solutions for customers, from small trial orders to large bulk purchases.
We provide:
✔ High purity raw materials
✔ Strict quality inspection
✔ Competitive factory pricing
✔ Fast response service
✔ Global shipping support
✔ Professional after-sales service
Sticking to the philosophy of Quality Priority and Customer Oriented, we sincerely welcome customers from all over the world to negotiate business and create win-win cooperation.
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