High Purity 5-Amino-1MQ Powder CAS 42464-96-0 For Metabolic Pathway Study

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Product Introduction

5-Amino-1MQ (5-Amino-1-methylquinolinium iodide) is a synthetic small-molecule laboratory research reagent and selective NNMT inhibitor. It is extensively adopted for biochemical and laboratory basic research. It regulates nicotinamide metabolism to adjust intracellular NAD+ concentration, methyl donor balance and cellular energy state. The product is offered in high-purity lyophilized powder form, applicable for laboratory exploration of metabolic pathways.

Mechanism of Action

5-Amino-1MQ serves as a competitive selective inhibitor of Nicotinamide N-methyltransferase (NNMT). It binds to the substrate binding region of NNMT and inhibits the methylation reaction of nicotinamide. Inhibited NNMT activity decreases nicotinamide consumption, retains nicotinamide for the NAD+ salvage pathway, raises intracellular NAD+ concentration and stabilizes S‑adenosylmethionine (SAM) reserves. Increased NAD+ triggers sirtuin-related signaling pathways, optimizes mitochondrial status and modulates lipid metabolism as well as epigenetic changes within laboratory cell models. Its IC50 value is approximately 1.2 μM, showing minimal incidental activity against other methyltransferases.

Research Applications

1. Biochemical study of NNMT enzyme activity and nicotinamide metabolic pathways
2. Study on NAD+ metabolism, mitochondrial status and intracellular energy balance
3. Laboratory research about lipid metabolism and adipose cell metabolic status
4. Study on cell senescence, sirtuin signaling and epigenetic regulation
5. Exploration of pharmacological cell models for metabolic disorders
6. Combined laboratory research with other metabolic regulating research reagents

Basic Chemical Information

• Product Name: 5-Amino-1MQ
• IUPAC Name: 5-amino-1-methylquinolin-1-ium iodide
• CAS No.: 42464-96-0
• Molecular Formula: C₁₀H₁₁IN₂
• Molecular Weight: 286.11 g/mol
• Appearance: Off-white to pale yellow crystalline powder
• Purity: ≥99% 
• Solubility: Water-soluble, soluble in DMSO
• Form: Lyophilized powder

Storage Conditions

Unopened lyophilized vials: Long-term storage at -20°C, sealed, dry and protected from light.

Short-term storage (within 12 months) at 2–8°C.

After dissolution: Store at 2–8°C, avoid light, and use within 30 days.

Prevent repeated freezing and thawing; keep away from high temperature and moisture.

Approved Indications

No official medical approval. This product is exclusively for scientific laboratory research purposes only. Not approved for clinical treatment or human consumption.

Core Advantages

1. High selectivity for NNMT enzyme with minimal interference to other methyltransferases.
2. Efficiently raises endogenous NAD+ levels and balances intracellular methyl donors.
3. Good cell membrane permeability, applicable to both in vitro cell assays and preclinical animal research.
4. High-purity lyophilized powder with stable chemical properties and long shelf life.
5. Complete batch test documents (COA) available to support laboratory verification.
6. Widely cited in published academic research for metabolic biology studies.

Packaging & Logistics

Standard specification: 5mg /10mg /50mg per lyophilized vial; 10 vials per box.

Packaging: Sealed glass vials with vacuum freeze-drying, moisture-proof outer package.

All packages are well concealed to avoid light and humidity.

Company Profile

We are a high-tech enterprise oriented towards research and development, specializing in the fields of pharmaceutical raw materials, intermediates, peptide components, cosmetic raw materials, and nutritional supplement raw materials. We offer standardized large-scale production services and conduct global wholesale business. Our multiple peptide raw materials possess core physiological effects such as weight loss, muscle building, blood sugar reduction, and anti-aging, are widely applicable to the research and production demands in the pharmaceutical, beauty, and health care sectors.

We adopt strict batch production standards and have sufficient production capacity and stable supply capabilities. All products have been professionally tested by third-party institutions and come with complete test reports and qualification certificates, ensuring stable batch quality and complete traceability. For large-scale orders, we offer competitive wholesale prices. We uphold the core values of integrity, pragmatism, innovation and development, and continuously enhance our technical strength and product quality.

We offer comprehensive high-quality fine raw materials for the pharmaceutical, cosmetic and nutritional product industries. At the same time, we not only support standard batch purchases but also can meet the needs of pilot projects and large-scale industrial production.