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1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride25952-53-8C8H18ClN3

Name: 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride25952-53-8C8H18ClN3
Brand: OORENT
SKU: pr2607231316
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CAS No.:

25952-53-8

Grade:

Pharmaceutical Grade

Content:

99%

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OORENT

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vial

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2026-08-23

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Description

Product Detail

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride Basic information

Product Name:	1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
Synonyms:	(3-dimethylaminopropyl)ethyl-carbodiimidmonohydrochloride;3-propanediamine,n’-(ethylcarbonimidoyl)-n,n-dimethyl-monohydrochloride;1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydroc;AT test ,only COA;EDC.HCI;N'-(Ethylkohlenstoffimidoyl)-N,N-dimethylpropan-1,3-diaminmonohydrochlorid;Avanafil Impurity 40;Diquafosol Impurity m
CAS:	25952-53-8
MF:	C8H18ClN3
MW:	191.7
EINECS:	247-361-2
Product Categories:	Aliphatics;straight chain compounds;Peptide Coupling Reagents;Biochemistry;heteroXlink;EDC;Condensation & Active Esterification;Coupling Reactions (Peptide Synthesis);Peptide Synthesis;Reagents for Oligosaccharide Synthesis;Synthetic Organic Chemistry;Peptide;Amine;Zero-Length Crosslinker;peptides;25952-53-8;top
Mol File:	25952-53-8.mol

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride Chemical Properties

Melting point	110-115 °C(lit.)
density	0.877 g/mL at 20 °C(lit.)
vapor pressure	0.002Pa at 20℃
refractive index	n20/D 1.461
storage temp.	-20°C
solubility	H2O: soluble1 gm/10 ml, clear to very slightly hazy, colorless to very faintly yellow
form	Crystalline Powder
color	White to off-white
Appearance	white solid
Water Solubility	Soluble
Sensitive	Hygroscopic
BRN	5764110
Stability:	Stable, but sensitive to moisture. Incompatible with strong acids, strong oxidizing agents, moisture.
Major Application	microbiology
InChI	1S/C8H17N3.ClH/c1-4-9-8-10-6-5-7-11(2)3;/h4-7H2,1-3H3;1H
InChIKey	FPQQSJJWHUJYPU-UHFFFAOYSA-N
SMILES	Cl.CCN=C=NCCCN(C)C
LogP	-2.98 at 25℃
CAS DataBase Reference	25952-53-8(CAS DataBase Reference)
EPA Substance Registry System	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride (25952-53-8)

Safety Information

Hazard Codes	C,Xi
Risk Statements	34-36/37/38-41-37/38-20/21/22
Safety Statements	26-36/37/39-45-37/39-36
RIDADR	UN 2735 8/PG 3
WGK Germany	3
RTECS	FF2200000
F	1-3-10
Hazard Note	Irritant
TSCA	TSCA listed
HS Code	29252000
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 3 Dermal Acute Tox. 4 Oral Aquatic Acute 1 Aquatic Chronic 1 Skin Irrit. 2 Skin Sens. 1 STOT RE 2 Oral
Toxicity	LD50 intravenous in mouse: 56mg/kg

MSDS Information

Provider	Language
EDAC.HCl	English
SigmaAldrich	English
ALFA	English

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride Usage And Synthesis

Description	EDC (N-ethyl-N’-(3-dimethylaminopropyl)carbodiimide) carbodiimide reagent for the activation of carboxylic acid and their subsequent coupling with amines. EDC is water soluble and provides a reliable method for activating carboxylic acids in aqueous media.
Chemical Properties	EDC-HCl, or 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, is a white crystalline powder that easily deliquescent and can dissolve in both water and ethanol. It is commonly used as an activating reagent in amide synthesis to activate carboxyl groups. It can also activate phosphate groups, cross-link proteins and nucleic acids, and produce immunocouplers. EDC-HCl is commonly applied in the pH range of 4.0-6.0 and is often used in conjunction with N-Hydroxysuccinimide (NHS) or N-Hydroxysulfosuccinimide sodium salt to improve coupling efficiency.
Uses	1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride is used as a carboxyl activating agent. It plays a vital role for immobilization of large biomolecules in association with N-hydroxysuccinimide. It is also used in the acylation of phosphoranes.
Application	1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride is water-soluble carbodiimide, widely used for peptide coupling. N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride has been used for the formation of FND (fluorescent nanodiamonds)-transferrin bioconjugates. It has been used for crosslinking polyethylenimine to gold particles. It has been used as a carbodiimide linkage agent for coating of carboxylated polystyrene beads with biotinylated BSA (bovine serum albumin).
General Description	EDC hydrochloride is a water-soluble derivative of carbodiimide useful for conjugating haptens to proteins and polypeptides. Used to modify NMDA receptors and as a condensing agent in peptide synthesis. The major advantage of EDAC coupling is the easy removal of excess reagent and the corresponding urea by washing with dilute acid or water. Carbodiimides catalyze the formation of amide bonds, carboxylic acids, and amines by activating the carboxylate to form an O-acylurea. This intermediate can be attacked by an amine directly to form an amide. EDAC is released as a soluble urea derivative.
Flammability and Explosibility	Flammable
reaction suitability	reagent type: cross-linking reagent reaction type: Peptide Synthesis
Biochem/physiol Actions	1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride(25952-53-8) is a water soluble condensing reagent. EDAC is generally utilized as a carboxyl activating agent for amide bonding with primary amines. Additionally, it reacts with phosphate groups. It has been utilized in peptide synthesis, crosslinking proteins to nucleic acids as well as preparation of immunoconjugates.
Mechanism of action	Carboxyl group activation with EDC. xHCl proceeds similarly to other carbodiimide couplings. The reaction of a carboxylic acid and the carbodiimide forms an O-acylisourea intermediate. The O-acylisourea is a highly reactive species that readily reacts with amines, peptide coupling additives, or reducing agents. EDC. HCl is transformed into the corresponding urea during coupling reactions. It has the advantage over DCU in that it can be removed from the reaction mixture by extraction or be washed out from solid phase synthesis applications. However, the O-acylisourea can rearrange irreversibly to an N-acyl urea and racemise the α-carbon of the amino acid via the formation of an oxazol-4(5H)-one [azlactone]. N-Acylurea formation and racemisation may be reduced by using intermediate nucleophiles, which convert the O-acylurea to an activated ester containing the nucleophile. The mechanism of amide bond formation applies both to EDC and EDC.HCl. The differences are that the free base can be applied as a bifunctional reagent: a coupling agent (carbodiimide) and a base (dimethylamino). At the same time, the HCl salt can form an O-acylisourea cyclic intermediate.
Synthesis	1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride can be used for the synthesis of amides.It is used as a coupling agent in the synthesis of esters from carboxylic acids using dimethylaminopyridine as the catalyst. Preparation method of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride(CN104193654A)
Purification Methods	It is an excellent H2O-soluble peptide coupling reagent. It is purified by dissolving (ca 1g) in CH2Cl2 (10mL) at room temperature and then add dry Et2O (~110mL) dropwise and the crystals that separate are collected, washed with dry Et2O, recrystallised from CH2Cl2/Et2O and dried in a vacuum over P2O5. It is important to work in a dry atmosphere or work rapidly and then dry the solid as soon as possible. The material is moderately hygroscopic, but once it becomes wet it reacts slowly with H2O. Store it away from moisture at -20o to slow down the hydrolysis process. The free base has b 47-48o/0.27mm, 53-54o/0.6mm, n 1.4582. The methiodide is recrystallised from CHCl3/EtOAc, the crystals are filtered off, washed with dry Et2O, recrystallised from CHCl3/Et2O, and dried in vacuo over P2O5, m 93-95o, 94-95o. [Sheehan et al. J Am Chem Soc 87 2492 1965, Sheehan & Cruickshank Org Synth Coll Vol V 555 1973.] § A polymer bound version is commercially available.
References	[1] Patent: CN104193654, 2016, B. Location in patent: Paragraph 0055

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride Preparation Products And Raw materials

Raw materials	[3-(Dimethylamino)propyl]dithiocarbamic acid-->(2E,2E)-3,3-(anthracene-9,10-diyl)diacrylic acid-->Pyridine hydrochloride-->(3-ISOTHIOCYANATO-PROPYL)-DIMETHYL-AMINE-->1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide-->3-Dimethylaminopropylamine
Preparation Products	6-BROMO-4-CHLORO-2-METHYL-QUINAZOLINE-->6-bromo-2-methylquinazolin-4(3H)-one-->2-AMINO-5-BROMOBENZAMIDE-->(E)-3-[4-[(E)-2-carboxyethenyl]phenyl]prop-2-enoic acid-->1-Methyl-cyclopropanesulfonic acid amide

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Basic Info

Product Name:

1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride

Other Name:

1,3-Propanediamine,N3-(ethylcarbonimidoyl)-N1,N1-dimethyl-,hydrochloride (1:1);Carbodiimide,[3-(dimethylamino)propyl]ethyl-,monohydrochloride;1,3-Propanediamine,N′-(ethylcarbonimidoyl)-N,N-dimethyl-,monohydrochloride;1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide monohydrochloride;1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride;N-Ethyl-N′-(3-dimethylaminopropyl)carbodiimide hydrochloride;1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide monohydrochloride;N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride;1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride;EDAP;EDCI;WSC;1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide monohydrochloride;EDC;1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride;[3-(Dimethylamino)propyl]ethylcarbodiimide hydrochloride;3-[3-(Dimethylamino)propyl]-1-ethylcarbodiimide hydrochloride;EDC (coupling agent);N1-((Ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine hydrochloride;N-[(Ethylimino)methylene]-N′,N′-dimethylpropane-1,3-diamine hydrochloride;N-[3-(Dimethylamino)propyl]-N1-ethylcarbodiimide hydrochloride;1-Ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride;93128-40-6

CAS No.:

25952-53-8

Molecular Formula:

C8H17N3.ClH

InChIKeys:

InChIKey=FPQQSJJWHUJYPU-UHFFFAOYSA-N

Molecular Weight:

191.7

Exact Mass:

191.119

BRN:

5764110

EC Number:

217-579-2

HScode:

29252000

Categories:

Amides

Characteristics

PSA:

XLogP3:

1.93390

Appearance:

White to off-white Crystalline Powder

Density:

0.877 g/mL at 20 °C(lit.)

Melting Point:

110-115 °C(lit.)

Boiling Point:

197.7°C at 760 mmHg

Flash Point:

107.9ºC

Refractive Index:

n20/D 1.461

Water Solubility:

H2O: soluble 1 gm/10 ml, clear to very slightly hazy, colorless to very faintly yellow

Storage Conditions:

−20°C

Vapor Pressure:

0.171mmHg at 25°C

Toxicity:

LD50 intravenous in mouse: 56mg/kg

See More 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Acute toxicity - Category 3, Dermal

Skin irritation, Category 2

Skin sensitization, Category 1

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed H311 Toxic in contact with skin H315 Causes skin irritation H317 May cause an allergic skin reaction H400 Very toxic to aquatic life H410 Very toxic to aquatic life with long lasting effects
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P273 Avoid release to the environment.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P316 Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P333+P317 If skin irritation or rash occurs: Get medical help. P391 Collect spillage.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

8 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	1-ETHYL-3-(3-DIMETHYLAMINOPROPYL)-CARBODIIMIDE HYDROCHLORIDE (EDAC-HCL)	10.00 MT	Feb 8, 2025
India	1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride	2 KG	Jun 3, 2026
India	1-Ethyl-3-(3- dimethylaminopropyl)carbodii mide hydrochloride (EDAC HCl)	1000.00 KG	Feb 25, 2026
India	N-ethyl-N’-(3-dimethylaminopropyl) carbodiimide (EDC)	0.01 L	Jul 8, 2025
India	1-Ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride	10 MT	Dec 27, 2024
United States	EDC HCI	1 KG	Jul 23, 2026
India	TRIFLUOROMETHANESULFONIC	10.00 MT	Feb 8, 2025
India	5-Bromothiophene-2-carbaldehyde	1.00 KG	May 6, 2026

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