Snap-8 Anti-Wrinkle Peptide CAS 868844-74-0 Cosmetic Grade Lyophilized peptide 10mg 20mg 50mg snap-9

1.  Description

Chemical Properties

Acetyl Octapeptide-1 is a synthetic linear octapeptide with a modified structure featuring N-terminal acetylation and C-terminal amidation. These modifications may improve its stability against enzymatic degradation and help maintain peptide integrity. It is chemically stable within a moderate pH range and shows good compatibility with common cosmetic ingredients such as retinol, boswellia, and hyaluronic acid.

Physical Properties

Acetyl Octapeptide-1 is a white to off-white crystalline powder with no obvious odor or taste. It has good water solubility and can dissolve in aqueous systems such as purified water, propylene glycol, and glycerin. The powder should be stored in a dry, sealed container away from light and high temperatures. Cosmetic-grade Acetyl Octapeptide-1 is typically supplied with high purity specifications.

Source and Preparation

Acetyl Octapeptide-1 is a synthetic peptide that is produced through solid-phase peptide synthesis. High-purity amino acids are assembled through controlled reaction steps, followed by purification processes such as high-performance liquid chromatography (HPLC) to obtain the final peptide product with consistent quality.

2.  Application

     High-end anti-aging skincare (core application): Acetyl octapeptide-1, as a “botulinum toxin-like” anti-wrinkle core ingredient, is widely incorporated into anti-wrinkle serums, firming creams, eye serums, neck creams, and similar products. It targets dynamic expression lines such as forehead wrinkles, crow's feet, and nasolabial folds. Suitable for early-aging skin (25+) and mature skin (35+), it can be used alone or combined with ingredients like Acetyl Hexapeptide-8 and Conchiolin Peptide to achieve dual improvement for both dynamic and static wrinkles.

    Medical Aesthetics Skincare: Acetyl octapeptide-1 is incorporated into post-Botox injection repair/maintenance products to prolong wrinkle-reducing effects (clinical data shows a 2-3 week extension) while alleviating post-injection skin stiffness and dryness. It can also be added to post-procedure repair products for photofacials, microneedling, and other aesthetic treatments, supporting skin barrier repair alongside anti-wrinkle benefits.

    Biomedical Research Field: Acetyl octapeptide-1 serves as a research tool in studying skin neuromuscular transmission mechanisms. It is used in fibroblast and skeletal muscle cell model experiments to investigate peptide regulation of neurotransmitter release and muscle contraction. Additionally, it functions as a positive control for anti-wrinkle peptide screening, providing experimental evidence for novel anti-aging peptide development.

3. Main Efficacy

    Targeted improvement of dynamic expression lines: Acetyl octapeptide-1 works by competitively inhibiting the formation of the SNARE complex (soluble N-ethylmaleimide-sensitive receptor attachment protein receptor) at the neuromuscular junction. This blocks the release of acetylcholine from nerve endings to muscle cells, reducing excessive facial muscle contraction and thereby diminishing dynamic expression lines (such as laugh lines and frown lines). Human clinical trials demonstrate that continuous application of 0.05% Acetyl Octapeptide-1 for 28 days reduces crow's feet depth by 21.7% and forehead wrinkle area by 18.9%, achieving efficacy comparable to low-concentration botulinum toxin without muscle stiffness side effects.

    Synergistic Improvement of Static Wrinkles and Skin Firmness: Beyond inhibiting dynamic wrinkles, Acetyl octapeptide-1 activates skin fibroblasts to promote synthesis of Type I and III collagen and elastin, enhancing dermal support to gradually improve static wrinkles caused by collagen loss. It also strengthens the dermal-epidermal junction (DEJ) structural integrity, boosting skin elasticity and firmness for a refined, plump complexion.

    Mild Safety & High Transdermal Penetration: With a molecular weight of only 994.1 Da, acetylation modification elevates its transdermal absorption rate to over 38%, enabling penetration through the stratum corneum to act in the superficial dermis. Non-cytotoxic (MTT assay shows >96% cell viability at concentrations ≤1 mg/mL) and non-sensitizing (negative HRIPT test), suitable for sensitive skin, pregnant women, and other special skin types, avoiding the invasiveness and potential risks associated with botulinum toxin injections.

Q1: Are you the manufacturer or trade company?
--We are the manufacturer in China, founded on 2011.

Q2: When will the product be shipped after payment?
--The parcel will be get ready and shipped within 1 day.

Q3: How long will it take to receive the parcel?
--3-5days for the US market; 3-7days for the others.

Q4: What can I do if I don't have the ability to clear the custom.
--We got experience after doing export for many years, so don't worry we can handle that.

Q5: Why should you buy from us not from other suppliers?
--Medium-sized enterprise integrating the development, production, sales and export and import trade of chemical products. Our factory has perfect infrastructure, advanced processing technology and completed detection means.