 Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Semaglutide for Sale > Semaglutide GLP-1 Peptide High Purity Research Grade White powder 99

Semaglutide GLP-1 Peptide High Purity Research Grade White powder 99 buy - large image1

Semaglutide GLP-1 Peptide High Purity Research Grade White powder 99 buy - image1

Semaglutide GLP-1 Peptide High Purity Research Grade White powder 99 buy - image2

Semaglutide GLP-1 Peptide High Purity Research Grade White powder 99 buy - image3

Semaglutide GLP-1 Peptide High Purity Research Grade White powder 99 buy - image4

Semaglutide GLP-1 Peptide High Purity Research Grade White powder 99

Name: Semaglutide GLP-1 Peptide High Purity Research Grade White powder 99
Brand: Novio
SKU: pr2607303057
Price: 60 USD
Availability: InStock

TDS 492 Inquiries

Unit Price:

$60/UNIT FOB

Get Latest Price 

CAS No.:

910463-68-2

Grade:

Industrial Grade

Content:

99%

Port:

Hongkong

Brand:

Novio

Packaging:

10 bottles/box

Price valid (until):

2026-08-30

Contact Supplier

 Chat Now

Beijing Novio Biotechnology Co., Ltd.

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Peptides,Cosmetic Raw Materials,Pharmaceutical Intermediates

 Visit Store

Product Description
Seller Information
Inquiry History

Description

Product Detail

Semaglutide Effects and Mechanism of Action

Comprehensive Introduction of Semaglutide (CAS No. 910463-68-2)

1. Overview of Semaglutide

Semaglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist and a synthetic peptide compound developed based on the structure of human GLP-1. It is a modified peptide molecule designed to provide enhanced stability and prolonged biological activity compared with native GLP-1.

Semaglutide belongs to the peptide hormone analogue family and consists of 31 amino acids. It has been widely studied in metabolic research due to its interaction with the GLP-1 receptor signaling pathway. The compound is commonly used in scientific research related to glucose metabolism, insulin secretion regulation, appetite control mechanisms, and energy balance.

Product Information:

Product Name: Semaglutide

CAS Number: 910463-68-2

Molecular Formula: C187H291N45O59

Molecular Weight: Approximately 4114 g/mol

Product Type: Peptide / GLP-1 Analog

Appearance: White Lyophilized Powder

Purity: ≥98% (HPLC)

Grade: Research Grade / Pharmaceutical Intermediate Grade

Semaglutide has attracted significant attention in pharmaceutical research because of its unique molecular characteristics, high receptor selectivity, and long-lasting activity.

2. Mechanism of Action of Semaglutide

The primary biological target of Semaglutide is the GLP-1 receptor, a receptor belonging to the class B G protein-coupled receptor family.

GLP-1 receptors are widely expressed in tissues associated with metabolic regulation, including pancreatic cells, gastrointestinal systems, and areas of the central nervous system involved in appetite regulation.

When Semaglutide binds to the GLP-1 receptor, it activates downstream intracellular signaling pathways, including cyclic adenosine monophosphate (cAMP)-related pathways. This activation contributes to several physiological responses associated with glucose balance and energy regulation.

The major mechanisms studied include:

2.1 Regulation of Glucose Metabolism

Semaglutide has been extensively researched for its ability to influence glucose metabolism through GLP-1 receptor activation.

The GLP-1 signaling pathway plays an important role in glucose-dependent insulin secretion. Research indicates that GLP-1 receptor activation may enhance pancreatic beta-cell responses when glucose levels are elevated.

Compared with short-acting GLP-1 molecules, Semaglutide demonstrates extended receptor activity due to structural modifications that improve resistance to enzymatic degradation.

2.2 Enhancement of Insulin Secretion Response

One of the important research areas involving Semaglutide is its relationship with pancreatic beta-cell function.

GLP-1 receptor stimulation can support glucose-dependent insulin secretion, meaning insulin release is primarily enhanced when glucose concentrations are elevated.

This glucose-dependent mechanism is an important characteristic of GLP-1 receptor agonists and has made Semaglutide a significant research compound in metabolic science.

2.3 Regulation of Glucagon Secretion

Glucagon is a hormone involved in increasing blood glucose availability.

Research on GLP-1 receptor signaling suggests that activation of this pathway may influence pancreatic alpha-cell activity and contribute to regulation of glucagon secretion.

Through modulation of insulin and glucagon signaling pathways, Semaglutide has become an important molecule for investigating glucose homeostasis.

3. Semaglutide and Appetite Regulation Research

A major research interest surrounding Semaglutide is its relationship with appetite and energy balance.

GLP-1 receptors are expressed in areas of the brain involved in appetite regulation. Semaglutide signaling has been investigated for its potential effects on:

Appetite-related pathways

Food intake regulation

Satiety signaling

Energy balance mechanisms

Research suggests that GLP-1 receptor activation may influence communication between peripheral metabolic signals and the central nervous system.

This makes Semaglutide an important research tool for studying the biological mechanisms involved in appetite control and metabolic regulation.

4. Research on Weight Management Mechanisms

Semaglutide has become one of the most widely studied peptide compounds in obesity and metabolic research.

Body weight regulation involves multiple biological systems, including:

Energy intake

Energy expenditure

Hormonal signaling

Gastrointestinal function

Central nervous system pathways

Semaglutide research focuses on how GLP-1 receptor activation may affect these interconnected processes.

Potential research areas include:

Appetite Signaling

Semaglutide has been investigated for its influence on appetite-related neural pathways and satiety signals.

Energy Balance

Researchers study the relationship between GLP-1 signaling and overall energy homeostasis.

Metabolic Adaptation

Semaglutide provides a valuable research model for understanding hormonal regulation of metabolism.

5. Gastrointestinal Research Applications

GLP-1 signaling is closely associated with gastrointestinal physiology.

Semaglutide research has examined its relationship with:

Gastric emptying regulation

Digestive system signaling

Nutrient sensing mechanisms

The interaction between GLP-1 receptors and gastrointestinal pathways represents an important field in metabolic science.

6. Semaglutide in Diabetes Research

Semaglutide has been extensively researched in the field of diabetes and glucose metabolism.

Diabetes research focuses on understanding:

Insulin signaling pathways

Pancreatic beta-cell function

Glucose homeostasis

Hormonal regulation mechanisms

As a GLP-1 receptor agonist analogue, Semaglutide serves as an important molecular tool for investigating these biological processes.

Researchers continue studying GLP-1-based compounds to better understand metabolic regulation and potential therapeutic applications.

7. Molecular Characteristics and Stability

Semaglutide has been structurally modified from native GLP-1 to improve molecular stability.

Important molecular characteristics include:

Long-Acting Peptide Structure

The molecular design of Semaglutide allows prolonged interaction with GLP-1 receptors compared with natural GLP-1.

Improved Enzyme Resistance

Structural modifications contribute to increased resistance against enzymatic breakdown.

High Molecular Specificity

Semaglutide demonstrates selective interaction with GLP-1 receptor pathways, making it valuable for biochemical research.

8. Laboratory Research Applications

Semaglutide is widely used in peptide and metabolic research laboratories.

Common research applications include:

Metabolic Pathway Studies

Used as a research compound for investigating hormone-related metabolic signaling.

GLP-1 Receptor Research

Supports studies related to receptor activation and intracellular signaling.

Peptide Biology Research

Used in investigations involving peptide structure, activity, and stability.

Drug Discovery Research

Provides a reference compound for developing and evaluating new peptide-based molecules.

9. Advantages of Semaglutide Research Compound

Semaglutide offers several characteristics that make it attractive for scientific research:

High Biological Relevance

Semaglutide is based on a naturally occurring human peptide hormone pathway.

Strong Research Interest

The compound has become a major focus in metabolic and peptide science.

Advanced Peptide Technology

Its molecular structure represents modern peptide engineering approaches.

Analytical Compatibility

Semaglutide can be characterized using advanced analytical techniques, including:

HPLC analysis

Mass spectrometry

Peptide identification methods

10. Quality Characteristics of Semaglutide

High-quality Semaglutide research materials are generally characterized by:

High purity profile

Accurate molecular identification

Consistent batch quality

Stable lyophilized formulation

Professional packaging

Typical analytical evaluation methods include:

HPLC Purity Testing

Used to evaluate chemical purity.

Mass Spectrometry

Used for molecular weight confirmation.

Appearance Inspection

Used to verify physical characteristics.

11. Storage and Handling Information

Semaglutide peptide products are commonly supplied as lyophilized powders.

Recommended storage conditions:

Temperature: -20°C recommended

Protect from moisture

Avoid repeated temperature fluctuations

Store in sealed containers

Proper storage helps maintain peptide stability and quality during research applications.

12. Future Research Potential

The discovery and development of GLP-1 receptor-based molecules have significantly expanded understanding of metabolic regulation.

Future research directions involving Semaglutide may include:

Advanced metabolic pathway studies

Combination peptide research

Next-generation GLP-1 analogue development

Peptide engineering technologies

Hormonal regulation research

As peptide science continues to advance, Semaglutide remains an important reference molecule in the study of metabolic biology.

Conclusion

Semaglutide is a highly studied GLP-1 receptor agonist peptide compound with significant importance in metabolic research. Through interaction with GLP-1 receptor pathways, Semaglutide provides researchers with valuable opportunities to investigate glucose regulation, insulin signaling, appetite mechanisms, energy balance, and peptide-based therapeutic strategies.

With its well-characterized molecular structure, high research interest, and broad application potential, Semaglutide continues to serve as an important compound in peptide science, biotechnology research, and pharmaceutical development.

Semaglutide CAS 910463-68-2 represents an advanced peptide research material suitable for laboratories, biotechnology companies, and pharmaceutical research organizations focusing on metabolic pathways and GLP-1 related studies.

Items	Specifications
Official Name	Semaglutide
CAS Number	910463-68-2
Molecular Formula	C187H291N45O59

Shop Semaglutide GLP-1 Peptide High Purity Research Grade White powder 99-Detailed Image 2

Shop Semaglutide CAS 910463-68-2 GLP-1 Peptide High Purity Research Grade-Detailed Image 3

Shop Semaglutide CAS 910463-68-2 GLP-1 Peptide High Purity Research Grade-Detailed Image 4

Shop Semaglutide CAS 910463-68-2 GLP-1 Peptide High Purity Research Grade-Detailed Image 5

Shop Semaglutide CAS 910463-68-2 GLP-1 Peptide High Purity Research Grade-Detailed Image 6

Shop Semaglutide CAS 910463-68-2 GLP-1 Peptide High Purity Research Grade-Detailed Image 7

Shop Semaglutide CAS 910463-68-2 GLP-1 Peptide High Purity Research Grade-Detailed Image 8

Shop Semaglutide CAS 910463-68-2 GLP-1 Peptide High Purity Research Grade-Detailed Image 9

Shop Semaglutide CAS 910463-68-2 GLP-1 Peptide High Purity Research Grade-Detailed Image 10

ECHEMI Editorial Reference

Semaglutide (CAS: 910463‑68‑2) is a synthetic lipid‑modified peptide analogue, consisting of a 31‑amino‑acid backbone with a covalently attached C18 fatty di‑acid side‑chain via a hydrophilic spacer. It shares 94% amino‑acid sequence homology with native human GLP‑1 peptide. The substance appears as white to almost white hygroscopic powder, with molecular formula C₁₈₇H₂₉₁N₄₅O₅₉ and molecular weight of 4113.58 g/mol. Structural modifications grant it resistance against DPP‑4 enzymatic degradation and enable reversible binding to serum albumin, contributing to its extended in‑vivo half‑life property.

Certificates

Basic Info

Product Name:

Semaglutide

Other Name:

Sermaglutide;Semaglutide impurity;Sermaglutide USP/EP/BP;semaglutide;Sermaglutide CAS 910463 68 2;Semaglutide (H-7894.0001);semgalutide;Semaglutide Injection

CAS No.:

910463-68-2

Molecular Formula:

C187H291N45O59

InChIKeys:

DLSWIYLPEUIQAV-CCUURXOWSA-N

Molecular Weight:

4113.57754

Exact Mass:

4113.122087 g/mol

EC Number:

203-405-2

Color/Form:

White to off-white

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

1650 Å²

XLogP3:

5.44520

Critical Temperature & Pressure:

Store at -20°C

Research

Class:

GLP-1R agonist

Status:

FDA-approved (Ozempic / Wegovy / Rybelsus)

Mechanism:

Long-acting, selective glucagon-like peptide-1 (GLP-1) receptor agonist with 94% sequence homology to human GLP-1. Engineered for extended half-life (~1 week) via albumin binding (fatty acid acylation at Lys26) and resistance to DPP-4 degradation (Aib substitution at position 8). Promotes insulin secretion, inhibits glucagon release, delays gastric emptying, and reduces appetite via central nervous system GLP-1R activation.

Activity note:

Potent, selective GLP-1R agonist. Reported binding affinity Ki = 0.38 ± 0.06 nM. Semaglutide is a human GLP-1 analog with structural modifications for albumin binding (C18 fatty diacid at Lys26) and enzymatic stability (Aib8 substitution).

Source:

Lau J, et al. J Med Chem. 2015;58(18):7370-7380. Wilding JPH, et al. N Engl J Med. 2021;384(11):989-1002.DOI

Clinical Development:

NCT03548935; NCT03552757; NCT01720446; NCT02692716

FDA:

Ozempic, Wegovy, Rybelsus (approved 2017-12-05)

References

ChEMBL:

DrugBank:

KEGG DRUG:

PubChem:

Literature:

NEJM: Wilding et al. (2021) — STEP-1; NEJM: Marso et al. (2016) — SUSTAIN-6; J Med Chem: Lau et al. (2015) — Discovery of Semaglutide; FDA: Ozempic (NDA 209637)

Disclaimer:

Semaglutide is approved as a prescription medicine (Ozempic, Wegovy, Rybelsus) in certain jurisdictions. This listing is for industrial and laboratory research use only. Research-chemical listings on B2B marketplaces are not interchangeable with approved medicines. Confirm CAS, specification, and regulatory pathway with the seller. It is not medical advice, a clinical recommendation, or an approved therapy description.

See More Semaglutide Properties 

Hazard Identification

Classification of the substance or mixture

Reproductive toxicity, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H361 Suspected of damaging fertility or the unborn child
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Semaglutide Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Peptides,Cosmetic Raw Materials,Pharmaceutical Intermediates

Location:
Room 1359, Room 103, Building Jia 19, Jixiang Garden, Tongzhou District, Beijing

Year of Establishment:
2026

Inquiry History

492 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Weight Loss Semaglutide intermediate 99% White powder COA High Quality peptide GLP-1 910463-68-2	5 MG	Apr 11, 2024
United States	Gene-Biocon Semaglutide 910463-68-2 GLP-1analogs diabetes weight loss 96% White or off-white powder	2	Dec 5, 2023
United States	Semaglutide 910463-68-2	1 G	Sep 21, 2023
United States	Sermaglutide 99% 910463-68-2	2 KG	Oct 21, 2023
China	Semaglutide CAS 910463-68-2	1 KG	Apr 16, 2026
United Kingdom	TGYFactory Supply Semaglutide Peptide 99% CAS 910463-68-2	50 MT	Nov 13, 2023
Sri Lanka	Bulk Supply 98% up Sermaglutide powder CAS 910463-68-2	300 G	Nov 18, 2023
United States	Semaglutide Ozempic Sermaglutide 99.9% white powder 910463-68-2 Teruiop	500 G	Oct 9, 2023
United States	Raw mateiral Semaglutide CAS 910463-68-2 99% White powder	1000 G	Sep 23, 2023
Switzerland	Semaglutide Ozempic Sermaglutide 99.9% white powder 910463-68-2 Teruiop	5000 MT	Sep 13, 2023
United States	High Purity Peptide Semaglutide 910463-68-2 With Safe Shipping	1 G	Sep 7, 2023
United States	10MG vial pack Semaglutide 99% 910463-68-2 GLP-1 Peptide	10 MT	Oct 18, 2023
United States	High Purity IGF-1 LR3 Peptide CAS 910463-68-2 IGF1 LR3	60 MG	Aug 4, 2025
United States	High Purity IGF-1 LR3 Peptide CAS 910463-68-2 IGF1 LR3	10 MT	Sep 19, 2025
United States	High Purity IGF-1 LR3 Peptide CAS 910463-68-2 IGF1 LR3	2	Nov 13, 2024
United States	semaglutide CAS 910463-68-2 in stock 2-4 days safe delivery	1 MT	Nov 4, 2023
United Kingdom	API Pharmaceutical Chemical Grade Raw Materials CAS 910463-68-2 Semaglutide	40 MT	Sep 27, 2023
United States	High Purity IGF-1 LR3 Peptide CAS 910463-68-2 IGF1 LR3	10	Sep 27, 2023
China	Semaglutide Tirzepatide for Weight Loss CAS: 910463-68-2 Retatrutide Cagrilintide	1 MT	Jul 5, 2025
India	Best Price 99% Semaglutide Peptide 10mg Vials Semaglutide CAS 910463-68-2	100	Nov 8, 2023

Go to Page

Post an enquiry for this product

More Choices Find All Products for Sale 

Product Name	Grade / Content	Price	Supplier Name	Details
Semaglutide Peptide Material with Reliable Quality Control	Research Grade/99	$50/UNIT FOB	PGpeptides	Inquiry
GMP Grade Peptide Raw Material 99% High Purity Freeze Dried Powder	Pharmaceutical Grade/99.6	$59-69/G FOB	Yiwu Haonen Trading Co., Ltd	Inquiry
ET10 provide home delivery service-available in stock in the warehouse	Pharmaceutical Grade/99.976	$40/MT FOB	Guangzhou Henghong Trading Co., Ltd.	Inquiry
Semaglutide SM2 SM5 SM10 SM15 SM20 SM30 Tir High-quality peptide products 99% Purity Factory Supply ksd	Pharmaceutical/99	$27/UNIT FOB	Jinan Kangshengda Technology Co., Ltd.	Inquiry
99% Purity Semaglutide 2381089-83-2 2mg 5mg 10mg Customize Lyophilized Powder Peptides Wholesale GLP-1 Sema	Pharmaceutical Grade/99		Zhengzhou Yueqi new material Co., LTD	Inquiry