Epitalon, also spelled Epithalon or Epithalone, is a synthetic tetrapeptide with the reference sequence Ala-Glu-Asp-Gly. Its reference molecular formula is C14H22N4O9 and its molecular weight is 390.35 g/mol. The short, well-defined sequence has attracted interest in cellular-aging, telomere-associated, gene-regulation, circadian, and pineal-biology research.

Epitalon is a compact peptide suitable for pathway studies, cell-aging models, biomarker panels, and comparison with related short peptides. The product name should be matched with its CAS number and sequence because several spelling variants are used internationally. The material is supplied only for laboratory research and analytical applications.

Mechanism of Action

Epitalon has been investigated in experimental systems evaluating telomerase-associated activity, telomere dynamics, proliferative history, chromatin organization, and age-related gene-expression patterns. These effects are not universal and may depend on cell type, passage number, exposure schedule, and assay method.

Research has also explored pineal-associated and circadian pathways, including changes in time-dependent signaling and oxidative-stress responses. The complete molecular mechanism remains under study, so a combination of molecular, cellular, and functional endpoints is more informative than a single marker.

Research Value

Epitalon provides a simple sequence-defined model for studying how a short peptide may influence age-associated cellular pathways. Its small size is useful for structure-activity comparison, sequence modification, analog screening, and integration into cell-based or molecular research programs.

The peptide supports multiple research directions, including cellular aging, telomere biology, circadian signaling, and oxidative balance. A well-characterized batch enables clearer comparison across study stages and reduces uncertainty caused by identity or purity differences.

Core Research Applications

Cellular aging and senescence models. Used to examine proliferative history, senescence markers, stress response, and cell-state changes.

Telomere-associated research. Suitable for studies of telomerase-related activity and telomere dynamics under defined conditions.

Gene regulation and chromatin biology. Used to explore age-associated transcriptional patterns and chromatin organization.

Circadian and pineal-biology research. Supports time-course studies of rhythmic signaling and pineal-associated pathways.

Short-peptide analog screening. Useful for sequence comparison, residue substitution, and structure-activity research.

Product Advantages

Compact four-residue sequence with straightforward identity confirmation.

Multiple research angles across cellular aging, telomere, circadian, and gene-regulation models.

Research-grade purity options supported by lot-specific analytical documentation.

Flexible packaging for screening, routine research, and larger comparative projects.

Custom sequence, analog, purity, and analytical-service options available upon project review.

Frequently Asked Questions

What should be confirmed before ordering? Confirm the exact product name, CAS number, molecular form, required quantity, purity target, packaging, destination, and document list. For modified or species-specific materials, also confirm the complete sequence and modification pattern.

Does 98% purity mean 98% active content? Not necessarily. Chromatographic purity is usually a relative peak-area result. Water, counter-ions, salts, and other non-volatile components may affect the weighed amount. Ask for the content basis when exact molar preparation is important.

Which documents are commonly available? A lot-specific Certificate of Analysis is the main document. Supporting chromatographic and mass data can be discussed, together with any additional test agreed before release.

Can the package size be customized? Yes, subject to material compatibility and production feasibility. Small research packs, multiple matched units, or larger research quantities can be reviewed during quotation.

How should a working concentration be selected? There is no single concentration suitable for every model. Researchers should begin with relevant published methods or prior internal data, then perform a range study with suitable controls.

How long can a prepared solution be kept? The answer depends on solvent, concentration, pH, temperature, light, container, and assay requirements. Use freshly prepared solution when possible or establish a validated holding period for the specific method.

Why is the lot certificate important? The certificate connects the physical material to its batch number, test results, product form, and storage statement. General website information cannot replace the delivered lot record.

Who is the intended customer? The material is intended for trained professionals in qualified laboratory, biotechnology, industrial research, academic, or contract research settings.

Research-Use Statement

This material is supplied solely for laboratory research and analytical work by trained professionals. It is not supplied for human or veterinary use, food use, household use, or diagnostic procedures. The purchaser is responsible for assessing suitability, reviewing the lot documents, establishing safe laboratory procedures, and following applicable institutional and local requirements.