59587-09-6 N-Acetyl-L-Cysteine Ethyl Ester

N-Acetyl-L-cysteine ethyl ester, commonly referred to as NACET, is a high-purity, lipophilic derivative of N-acetyl-L-cysteine (NAC). This compound is specifically designed to overcome the bioavailability limitations of standard NAC by featuring an ethyl ester group that significantly enhances its cell membrane permeability. As a result, NACET achieves superior passive diffusion across biological barriers, making it a highly efficient intracellular delivery system for cysteine and glutathione precursors.
With a molecular formula of C₇H₁₃NO₃S and a molecular weight of 191.25, NACET appears as a white to off-white crystalline powder with a purity of 98% or higher as determined by HPLC. Once inside the cell, the ester bond is rapidly cleaved by intracellular esterases, releasing free NAC and subsequently cysteine. This cysteine serves as the rate-limiting substrate for glutathione synthesis, leading to a marked and sustained elevation of intracellular glutathione levels. Additionally, NACET functions as a promising hydrogen sulfide donor, contributing to its broad spectrum of biological activities.
This compound is widely utilized in antioxidant and redox biology research, where it serves as a potent protective agent against oxidative stress induced by hydroperoxides and other reactive oxygen species. It is also extensively employed in mucolytic research, detoxification studies—particularly in models of paracetamol intoxication—and in the development of nutraceutical formulations targeting anti-aging, cellular detoxification, and longevity support. Furthermore, NACET is a valuable tool in pharmaceutical research for neurological, ocular, and cardiovascular applications, as well as in cell-based assays requiring reliable thiol delivery and modulation of redox status.
NACET is available in a variety of packaging options to suit different research and production needs, including 1 kilogram bags and 25 kilogram drums, with custom packaging available upon request. For optimal stability, the product should be stored in powder form at -20°C for long-term preservation, ensuring a shelf life of up to three years, while room temperature storage is acceptable for short periods not exceeding one month. The product is shipped at ambient temperature under standard conditions.