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High Purity Dihexa Peptide CAS 1401708-83-5 Brain-Penetrant Lyophilized Powder Bulk Supply With COA

TDS 162 Inquiries

Unit Price:

$40-50/UNIT EXW

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CAS No.:

1401708-83-5

Grade:

Pharmaceutical Grade

Content:

99%

Port:

海南

Brand:

SDR

Packaging:

Bottled

Price valid (until):

2027-02-28

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Hainan Terte New Materials Co., Ltd.

Company Type:

Trader

Location:

China

Qualification:

Main Products:

peptides,Semagiutide,Retatrutide,GHK-CU,MOTS-c,Semax

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Product Description
Seller Information
Inquiry History

Description

Product Introduction

Items	Specifications
Packaging method	Bottled
Purity	99%
Product abbreviation	DI
Dosage	10mg*10vials

Dihexa, also known as PNB‑0408, is a synthetic angiotensin‑IV‑derived peptide compound with powerful blood‑brain‑barrier penetration and improved metabolic stabilitydihexa.co..... It acts as a high‑affinity potentiator targeting the HGF/c‑Met signaling complex, amplifying downstream PI3K/Akt and MAPK/ERK signaling cascades within neuronal cellsPeptide Bi.... This peptide supports neuronal survival, neurite outgrowth, dendritic spine formation and synaptogenesis, contributing to synaptic plasticity and neural network reconstruction. Pre‑research data indicates it exhibits potent bioactivity at picomolar concentrations, and it is widely applied in research related to cognitive function, age‑related neural decline, Alzheimer’s disease models and brain injury repair. The lyophilized Dihexa powder shows good storage stability. Each batch is verified by HPLC and mass spectrometry to guarantee product consistency for mechanism research and pre‑project exploration.

Company Profile

We are a high-tech enterprise dedicated to the research and development of innovative peptide compounds, customized synthesis and supply of scientific research raw materials. We are deeply involved in the fields of peptide chemical synthesis, purification processes and quality analysis, providing high-quality peptide research raw materials and technical support services to domestic and foreign university laboratories, pharmaceutical research institutions and CRO enterprises.
The company has gathered professional technical teams specializing in peptide synthesis, analysis and testing, and process development. It has established a complete peptide synthesis laboratory, purification platform and quality control testing system, and possesses the capacity for large-scale preparation of long-chain peptides, modified peptides and novel target peptides. It can provide integrated technical support including solid-phase synthesis, liquid-phase synthesis, chromatographic purification, structural characterization and stability research.
The core scientific research raw material product line covers GLP-1-related target peptides and various innovative active peptide intermediates, among which Retatrutide (LY3437943) is a scientific research grade peptide raw material. All products are for in vitro scientific research and experimental use only. They must not be used for human trials, clinical drug administration, medical aesthetics or any diagnostic or therapeutic purposes.
The company has established a standardized quality control process. Each batch of raw materials is accompanied by HPLC purity testing and MS mass spectrometry structure verification reports, strictly controlling key indicators such as purity, impurities, and moisture. We can provide services such as repackaging in different specifications, customized synthesis, and process optimization, supporting the experimental needs of research institutions for the early-stage pharmacological research and mechanism exploration of new drug targets.
Since its establishment, the enterprise has adhered to the concept of compliant operation, strictly abided by relevant laws and regulations on pharmaceutical research and development, and established long-term and stable cooperation with many domestic universities and drug research and development laboratories. With stable product quality, efficient delivery capabilities and professional technical consulting services, we support the basic research of innovative metabolic target drugs and continuously provide reliable raw material support for global peptide basic scientific research.

Business philosophy

Focus on the innovative research and development of peptides, strictly adhere to the boundaries of scientific research and application, prioritize quality, and achieve win-win results through integrity

Contact information

Email: 1060575270@qq.com

W hatsapp:+852 5976 3637

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Basic Info

Product Name:

Dihexa

Other Name:

L-Isoleucinamide,N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-;N-(1-Oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-L-isoleucinamide;Dihexa;N-Hexanoic-Tyr-Ile-(6)aminohexanoic amide

CAS No.:

1401708-83-5

Molecular Formula:

C27H44N4O5

InChIKeys:

InChIKey=XEUVNVNAVKZSPT-JTJYXVOQSA-N

Molecular Weight:

504.7

Exact Mass:

504.66

Categories:

Bulk Drug Intermediates

Characteristics

Density:

1.111±0.06 g/cm3(Predicted)

Boiling Point:

866.2±65.0 °C(Predicted)

Research

Class:

Angiotensin IV-derived oligopeptide / HGF-c-Met potentiator

Status:

Research compound — Not FDA approved

Mechanism:

A synthetic, orally active, blood-brain-barrier-permeable oligopeptide (Hexanoyl-Tyr-Ile-Ahx-NH₂) derived from angiotensin IV. Dihexa binds hepatocyte growth factor (HGF) with high affinity (Kd = 65 pM) and allosterically potentiates HGF activity at its receptor c-Met, promoting dendritic spinogenesis and synaptogenesis. In preclinical models it was reported to be seven orders of magnitude more potent than BDNF at promoting synapse formation. Note: the foundational 2014 paper (McCoy AT, et al. Neurobiol Learn Mem. 2014) was retracted in 2025.

EC50 (HGF Binding KD):

65 pM

Activity note:

Dihexa is an HGF potentiator, not a direct receptor agonist. It does not activate c-Met alone but markedly augments HGF-induced c-Met activation at low nanomolar HGF concentrations. Functional synaptogenic activity was reported at 10⁻¹°–10⁻⁻ M (original data now subject to retraction).

Source:

Original report: McCoy AT, et al. Neurobiol Learn Mem. 2014;115:112-120 (retracted 2025). Benoist CC, et al. J Pharmacol Exp Ther. 2014;351(3):628-637.

Clinical Development:

NCT04488419

References

PubChem:

PubChem

UNII:

9WYX65A5C2

Literature:

Benoist CC, et al. J Pharmacol Exp Ther. 2014 — HGF/c-Met mechanism; McCoy AT, et al. Neurobiol Learn Mem. 2014 — Synaptogenesis data (Retracted 2025); Athira Pharma: Fosgonimeton (prodrug) pipeline status

Disclaimer:

Dihexa is NOT FDA-approved or EMA-approved as a medicine. It is a research compound only. The foundational 2014 paper describing its synaptogenic potency was retracted in 2025. Its phosphate prodrug fosgonimeton failed a Phase 2/3 Alzheimer’s trial (LIFT-AD, 2024). This listing is for industrial and laboratory research use only. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

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Seller Information

Business Type:
Trader

Main Products:
peptides,Semagiutide,Retatrutide,GHK-CU,MOTS-c,Semax

Location:
Units 1503-14, 15th Floor, New HNA Building, No. 7 Guoxing Avenue, Lantian Subdistrict, Meilan District, Haikou City, Hainan Province

Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
3

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
101-200

Year of Establishment:
2025

Inquiry History

162 Inquiries

Country	Product	Purchase Quantity	Date Posted
Canada	Dihexa 1401708-83-5	1 G	Mar 8, 2026
Bulgaria	Customized peptides high purity Dihexa with fast shipping door to door CAS 1401708-83-5	10 G	May 27, 2025
United States	Dihexa	25 G	Jan 26, 2025
Russia	DIHEXA	50.00 G	Aug 14, 2024
Canada	Dihexa	130	Aug 12, 2026
Brazil	dihexa	90 MG	Aug 4, 2026
United States	Dihexa raw powder	10 G	Jul 26, 2026
Singapore	Dihexa	10 PCS	Jul 15, 2026
United States	Dihexa	1 G	Jul 11, 2026
Sweden	Dihexa	10 PCS	Jul 8, 2026
Australia	Dihexa	1 MT	Jul 2, 2026
United States	Dihexa	10 G	Jun 14, 2026
Germany	Dihexa	1 G	May 25, 2026
Thailand	Dihexa	1 G	May 12, 2026
United States	Dihexa	100 G	May 4, 2026
Italy	simona migliori	10 MT	Apr 23, 2026
United States	Dihexa	10 G	Apr 22, 2026
United States	Dihexa	1 G	Apr 22, 2026
Ecuador	DIHEXA	10 PCS	Apr 19, 2026
United States	dihexa	10 MG	Apr 13, 2026

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High Purity Dihexa Peptide CAS 1401708-83-5 Brain-Penetrant Lyophilized Powder Bulk Supply With COA

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