Best Price Semaglutide Lyophilized Powder High Quality Bulk Supply For Laboratory Use

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• Mechanism of Action:                                                
• Semaglutide functions as a highly selective agonist for the GLP-1 receptor (GLP-1R), a class B G-protein coupled receptor expressed in various tissues including pancreatic beta cells, the central nervous system, gastrointestinal tract, heart, and kidneys .
  
  
  Upon receptor binding, semaglutide activates adenylyl cyclase, increasing intracellular cyclic adenosine monophosphate (cAMP) levels and initiating downstream signaling cascades involving protein kinase A (PKA) and Epac2 . The unique fatty acid modification allows semaglutide to reversibly bind to serum albumin, protecting it from enzymatic degradation by DPP-4 and extending its biological half-life to approximately 7 days in research subjects .

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  Research Applications:                                               

• Semaglutide is exclusively intended for in vitro and in vivo laboratory research use only. Its primary research applications include:
  
  
  • Studies on GLP-1 receptor signaling pathways and mechanisms of action
  • Endocrine and metabolic disorder research
  • Investigations into glucose homeostasis and insulin secretion regulation
  • Preclinical pharmacology and drug development studies
  • Multi-peptide synergy research
  • Cellular metabolism and energy homeostasis studies
  • Tissue-specific GLP-1R expression and function research
  
  

• Product Specification:                                                
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• Product	Semaglutide
  CAS Number	910463-68-2
  Molecular Formula	C₁₈₇H₂₉₁N₄₅O₅₉
  Molecular Weight	4113.64 g/mol
  Amino Acid Sequence	H-{Aib}-EGTFTSDVSSYLEGQAA-{C18 diacid-γ-Glu-(AEEA)₂-Lys}-EFIAWLVRGRG
  Appearance	Fine white lyophilized powder
  Purity	≥99% (HPLC verified)
  Endotoxin Level	<0.1 EU/mg
  Solubility	Soluble in water (pH 7.0) and DMSO (1 mg/mL)
  Storage	-20°C for lyophilized powder (stable for 2 years); 4°C for reconstituted solution (up to 7 days); -20°C for reconstituted solution (up to 1 month, aliquoted)

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Company Profile：                                                      

EnShi Technology Co., Ltd is a modern advanced enterprise specializing in production and exportation of APIs, Pharmaceutical intermediates, plant extracts etc. Our products are widely used in medicine, health care products, cosmetics, nutritional supplements and food additives areas. With years of experience in the pharmaceutical chemical and biosynthetic industries.It provides compliant, stable and cost-effective core raw materials as well as one-stop CDMO/CMO solutions for global pharmaceutical enterprises and innovative drug R&D institutions.