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PNC-27 raw material CAS: 1159861-00-3 99% purity Factory direct sales buy - image1

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PNC-27 raw material CAS: 1159861-00-3 99% purity Factory direct sales

Name: PNC-27 raw material CAS: 1159861-00-3 99% purity Factory direct sales
Brand: Tong peptide
SKU: pr2608241438
Price: 175 USD
Availability: InStock

TDS 231 Inquiries

Unit Price:

$175/MT FOB

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CAS No.:

77-92-9

Grade:

Pharmaceutical Grade

Content:

99%

Port:

China

Brand:

Tong peptide

Packaging:

10mg/1box*10vials

Price valid (until):

2026-08-31

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Tong peptides

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

retatrutide,TB-500,GHK-CU,peptide

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Product Description
Seller Information
Inquiry History

Description

Whatsapp:+852 5492 9445

Email: ally@tongpeptides.com

PNC-27 is a synthetic anticancer peptide derived from the tumor suppressor protein p53. With its unique molecular design and mechanism of action, it has shown great potential in targeted therapy research for various cancers while minimizing damage to normal cells.

Developed by Dr. Joseph M. Dahabieh and his team at the State University of New York Downstate Medical Center in the early 21st century, the peptide was initially designed to mimic the MDM-2 binding domain in p53, achieving targeted anticancer effects.

Precise Targeting of Cancer Cells:

HDM-2 protein is a key regulatory factor that inhibits p53 function. It is highly overexpressed on the cell membranes of various cancer cells, while its expression level is extremely low or absent in normal cells. PNC-27 can bind to HDM-2 on cancer cell membranes with high affinity. This targeting ability is the core reason for its distinction between cancer cells and normal cells, as well as an important factor contributing to its low toxicity.

Inducing Cancer Cell Necrosis:

After binding to HDM-2 on cancer cell membranes, PNC-27 first forms a 1:1 complex, which then dimerizes to form transmembrane pores on the cancer cell membrane. This leads to the rapid leakage of intracellular contents, ultimately causing cancer cell lysis and necrosis. The formation of these pores can be directly observed using high-resolution scanning immunoelectron microscopy. Moreover, this process is independent of the status of the intracellular p53 gene—even if the p53 pathway is impaired in cancer cells, PNC-27 can still exert its anticancer effects.

Activating Apoptosis-Related Pathways to Assist Anticancer Effects

In addition to directly lysing cancer cells, it can also induce mitochondrial membrane depolarization and caspase activation in cancer cells, further activating the cell's intrinsic apoptotic pathway and enhancing the killing effect on cancer cells.

Research Application Scenarios and Potential

Adapting to Various Cancer Types:

In preclinical studies, PNC-27 has demonstrated cytotoxic activity against a variety of cancer cell lines, including solid tumors such as lung cancer, colorectal cancer, breast cancer, and pancreatic cancer, as well as hematological malignancies such as leukemia and lymphoma. It has also successfully treated highly metastatic pancreatic tumors and stem cell-rich human acute myeloid leukemia in nude mice without significant off-target effects.

Assisting in the Treatment of Drug-Resistant Cancers

PNC-27 also exhibits cytotoxicity against chemotherapy-resistant cancer strains. This provides a new research direction for addressing the common problem of drug resistance in cancer treatment and is expected to bring new therapeutic ideas to patients who are ineffective against traditional chemotherapy.

Synergistically Enhancing the Efficacy of Other Drugs:

Studies have found that PNC-27 can synergize with various anticancer drugs such as rapamycin, methotrexate, and paclitaxel. It can significantly reduce the half-maximal inhibitory concentration required for these drugs to kill cancer cells and enhance their anticancer effects. Therefore, it is expected to be used as an adjuvant therapeutic drug in combined anticancer regimens.

Significant Advantages:

Compared with traditional chemotherapeutic drugs, the greatest advantages of PNC-27 are its strong selectivity and low toxicity. Traditional chemotherapeutic drugs often cause severe damage to normal cells while killing cancer cells, leading to a series of side effects such as hair loss, nausea, and decreased immunity. In contrast, PNC-27 only targets cancer cells with high HDM-2 expression and causes almost no harm to normal cells, which can greatly reduce treatment-related side effects and improve the quality of life of patients after treatment.

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Why Choose Us

Strict‑Standard Quality Inspection

Each batch comes with complete test files, including HPLC‑based purity reports and mass‑spectrometry identification in the Certificate of Analysis (CoA). Typical purity exceeds 98%. We guarantee stable product identification, high purity and consistent quality across batches.

Lab‑Oriented Raw‑Material Supplier

Our biochemical raw materials cater to research‑and‑development labs, pre‑clinical trials, and commercial production in the biotechnology, skincare and nutritional‑supplement sectors.

Stable Worldwide Logistics Service

Cooperating with trusted logistics providers, we provide safe, confidential and temperature‑controlled international delivery, making sure goods arrive safely and on schedule.

Flexible Service for Different‑Order Demands

We support small lab‑use samples as well as large‑scale bulk purchases. Qualified clients can access customized purity adjustment, ingredient mixing and private‑label packaging services.

FAQ

Q1. How do you ensure product quality?
A: We have a strict quality management system, all batches must be tested and meet our standards before entering the warehouse. The purity of all our products is above 99.00%, which has been verified by many American and European customers.

Q2. How to place an order with you?
A: Once we confirm the required dosage/strength and quantity of the product with the customer, and the customer confirms and makes payment, we will arrange shipment as soon as possible.

Q3. What payment methods are there?
A: There are Bank Transfer, Tether USD(USDT) and Bitcoin(BTC).

Q4. What shipping methods can we choose?
A: Usually express delivery is more suitable, including DHL, FedEx, UPS, etc. We will be responsible for customs clearance in the destination country, and customers are not required to cooperate with customs clearance and pay any tariffs.

If you would like to know more about product quality, purity data, dosage guidance and professional product efficacy information, feel free to get in touch with us. We are a Chinese integrated factory combining production and trade, and we can offer you competitive factory‑direct prices.

Reach me via WhatsApp: +852 7044 4859

ECHEMI Editorial Reference

Citric acid is a weak organic tricarboxylic acid found in citrus fruits. Citric acid is a natural preservative and food tartness enhancer.

Certificates

Basic Info

Product Name:

Citric acid

Other Name:

1,2,3-Propanetricarboxylic acid,2-hydroxy-;Citric acid;2-Hydroxy-1,2,3-propanetricarboxylic acid;Aciletten;Citretten;Citro;Hydrocerol A;Chemfill;3-Carboxy-3-hydroxypentane-1,5-dioic acid;F 0001 (polycarboxylic acid);Uro-trainer;E 330;Suby G;NSC 112226;NSC 30279;NSC 626579;Celenex 3P6;2-Hydroxy-1,2,3-propanetricarboxyic acid;2-Hydroxypropan-1,2,3-tricarboxylic acid;INS 330;FE 2;F 4020;Grindsted Pro Tex TR 100;Citric acid monoglyceride;Monoglyceride citrate;Jet Setter;EL 4;EL 4 (polycarboxylic acid);Cellborn SC-C;KK 120;BioLink Acidifier;TBA 80;PAS 33;8: PN: WO2017048620 SEQID: 13 claimed sequence;F 3500;C 1949;3-Hydroxy-3-carboxy-1,5-pentanedioic acid;3-Hydroxy-pentane-1,3-5-trioic acid;3-Carboxy-3-hydroxy-pentanedioic acid;Liquinat L 50;12262-73-6;43136-35-2;136108-93-5;245654-34-6;623158-96-3;856568-15-5;878903-72-1;890704-54-8;896506-46-0;906507-37-7;1192555-95-5;2023788-69-2

CAS No.:

77-92-9

Molecular Formula:

C6H8O7

InChIKeys:

InChIKey=KRKNYBCHXYNGOX-UHFFFAOYSA-N

Molecular Weight:

192.12400

Exact Mass:

192.12

EC Number:

222-394-5

HScode:

2918140000

Categories:

Polypeptide

Characteristics

PSA:

132.13000

XLogP3:

-1.7

Appearance:

White crystalline powder

Density:

1.665 g/cm³ @ Temp: 20 °C

Melting Point:

153 °C

Boiling Point:

142-143 °C

Flash Point:

100ºC

Refractive Index:

1.493~1.509

Water Solubility:

H2O: 750 g/L (20 ºC)

Storage Conditions:

Store at RT.

Vapor Pressure:

<0.1 hPa (20 °C)

Toxicity:

LD50 in mice, rats (mmol/kg): 5.0, 4.6 i.p. (Gruber, Halbeisen)

Flammability characteristics:

0.28-2.29 KG/CU M (DUST)

Explosive limit:

vol% in air: 0.28.29

Odor:

Odorless

Taste:

Strongly acidic taste

PKA:

2.79None

See More Citric acid Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Separated from strong oxidants, strong bases, metal nitrates and metals. Dry.Crystalline citric acid, anhydrous, can be stored in dry form without difficulty, although conditions of high humidity and elevated temperatures should be avoided to prevent caking. Storage should be in tight containers to prevent exposure to moist air. Several granulations are commercially available with the larger particle sizes having less tendency toward caking.

See More Citric acid Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
retatrutide,TB-500,GHK-CU,peptide

Location:
1-1, Kailuo Road, Taojia Town, Jiulongpo District, Chongqing

Payment Terms:
TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance

Total Annual Revenue:
$10 million-$25 million

Total Employees:
501-1000

Year of Establishment:
2023

Pharma Grade Peptides is your premium source for high-quality purified research peptides.

We have served over 20,000 customers on Alibaba and now offer the same quality at our independent store.

Over the course of many years, we have empowered researchers and scientists to
explore new avenues of scientific discovery.

Inquiry History

231 Inquiries

Country	Product	Purchase Quantity	Date Posted
Pakistan	Citric acid 99% White Powder cas 77-92-9 Citric acid	50 MT	Oct 10, 2023
Turkey	Citric acid 99% White Powder cas 77-92-9 Citric acid	25 MT	Nov 10, 2023
United Kingdom	Citric Acid	1 20' Fcl	Feb 28, 2024
United Kingdom	Citric Acid Anhydrous	12 TON	Nov 5, 2024
India	citric acid	100 MT	Jul 20, 2026
Russia	citric acid anhydride	100 MT	Feb 22, 2024
Egypt	Citric acid	25.00 MT	Aug 24, 2026
Egypt	Citric acid	1.00 20' Fcl	Aug 7, 2026
India	citric acid	1 KG	Aug 6, 2026
Malaysia	Citric acid	10	Jul 17, 2026
Brazil	CITRIC ACID ANHYDROUS	1000 KG	Jun 29, 2026
Brazil	CITRIC ACID ANHYDROUS	1 20' Fcl	Jun 26, 2026
Uganda	Citric Acid	25 KG	May 27, 2026
United States	Citric ACID	5 MT	May 19, 2026
United States	Citric Acid	125 MT	Apr 29, 2026
India	Citric acid Anhydrous	500.00 KG	Apr 16, 2026
Egypt	citric acid	10.00 MT	Apr 7, 2026
Oman	Citric Acid	10 MT	Mar 26, 2026
Canada	Citric acid	1600 KG	Mar 14, 2026
South Korea	Citric acid anhydrous	10 G	Mar 11, 2026

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