Angelol M 98% Purity Angelol-type Coumarin Standard CAS 1092952-64-1 Research Grade Reference Standard

Product Overview

Angelol M is a naturally occurring coumarin derivative isolated from the roots of Angelica pubescens f. biserrata (Duhuo). It belongs to the angelol-type coumarins and is a higher molecular weight analogue with additional oxygenation. This compound is one of the later-discovered members of the angelol family and serves as an important reference standard for comprehensive quality control of Angelica products.

With the molecular formula C₂₂H₂₈O₈ and a molecular weight of 420.45 g/mol, this compound appears as a white to off-white crystalline powder. It is soluble in methanol, ethanol, and DMSO. The product is supplied at ≥98% purity as determined by HPLC analysis.

Synthetic Process

Angelol M is obtained through isolation from plant sources:

1. Extraction: Dried roots of Angelica pubescens are extracted with organic solvents such as ethyl acetate or methanol.

2. Chromatographic Separation: The extract is fractionated using silica gel column chromatography with gradient elution.

3. Purification: Final purification is achieved through preparative HPLC.

4. Identity Confirmation: Structure is confirmed by comprehensive spectroscopic analysis including NMR (1D and 2D) and mass spectrometry.

Mechanism of Action & Applications

Angelol M, like other angelol-type coumarins, is of interest for its potential biological activities. Research on related compounds suggests potential anti-inflammatory and anti-platelet aggregation properties.

This compound is primarily used as:

• Reference Standard: For the quantification of angelol-type coumarins in Angelica products.

• Quality Control: Used in the quality assessment of Duhuo (Angelica pubescens) and related herbal medicines.

• Natural Product Chemistry: Serves as a reference for coumarin identification and structural characterization.

Quality Specifications

• Purity: ≥98.0% determined by HPLC.

• Identity: Confirmed by NMR and mass spectrometry.

• Loss on Drying: ≤1.0%.

• Each batch is accompanied by a comprehensive Certificate of Analysis (COA).

• Stable for 36 months when stored at 2-8°C in sealed containers, protected from light.

Packaging & Storage

• Standard packaging: 2mg, 5mg, 10mg amber glass vials.

• Store at 2-8°C, protected from light and moisture.

• For long-term storage, keep at -20°C for up to 3 years.

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.