Pramipexole CAS 104632-26-0 Dopamine D2/D3 Receptor Agonist for Parkinson's Disease Research hfd
TDS 1 Inquiries
104632-26-0
Reagent Grade
99%
qingdao
//
5g, 25g, 100g, 500g
2026-09-27
Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceOff-White SolidChEBI: A member of the class of benzothiazoles that is 4,5,6,7-tetrahydro-1,3-benzothiazole in which the hydrogens at the 2 and 6-pro-S-positions are substituted by amino and propylamino groups, respectively.
Solid
Pramipexole is a member of the class of benzothiazoles that is 4,5,6,7-tetrahydro-1,3-benzothiazole in which the hydrogens at the 2 and 6-pro-S-positions are substituted by amino and propylamino groups, respectively. It has a role as an antiparkinson drug, a dopamine agonist, an antidyskinesia agent and a radical scavenger. It is a member of benzothiazoles and a diamine. It is a conjugate base of a pramipexole(2+).|Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD). It is a non-ergot dopamine agonist drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement). It was first approved by the FDA in 1997. Parkinson's Disease is one of the most common neurodegenerative disorders and causes a high level of disability in patients, leading to increased difficulty in performing activities of daily living due to symptoms that progress over time. The prevalence of Parkinson's Disease worldwide has increased from approximately 2.5 million in 1990 to about 6.1 million in 2016. This increase may be attributed to an aging population along with other contributing factors. In addition to the above FDA approval for Parkinson's Disease, pramipexole was also approved by the FDA in 2006 for the treatment of Restless Legs Syndrome (RLS). RLS is a sleep-related disorder characterized by unpleasant sensations in the lower extremities, often accompanied by an uncontrollable urge to move the legs.|Pramipexole is a Nonergot Dopamine Agonist. The mechanism of action of pramipexole is as a Dopamine Agonist.|Pramipexole is a selective dopamine receptor agonist used in the therapy of Parkinson disease. Pramipexole therapy is associated with a low rate of transient serum enzyme elevations during treatment, but has not been implicated in cases of clinically apparent acute liver injury.|A benzothiazole derivative and dopamine agonist with antioxidant properties that is used in the treatment of PARKINSON DISEASE and RESTLESS LEGS SYNDROME.Certificates-
TDS
Basic Info-
Product Name:
Pramipexole
Other Name:2,6-Benzothiazolediamine,4,5,6,7-tetrahydro-N6-propyl-,(6S)-;2,6-Benzothiazolediamine,4,5,6,7-tetrahydro-N6-propyl-,(S)-;(6S)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine;Pramipexole;SND 919;SUD 919CL2Y;U 98528E;(-)-Pramipexole;(S)-2-Amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole;(S)-Pramipexole;6-Propylamino-4,5,6,7-tetrahydro-1,3-benzothiazole-2-amine;(6S)-N6-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine;(6S)-6-N-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
CAS No.:104632-26-0
Molecular Formula:C10H17N3S
InChIKeys:InChIKey=FASDKYOPVNHBLU-ZETCQYMHSA-N
Molecular Weight:211.33
Exact Mass:211.33
EC Number:1806241-263-5
UNII:83619PEU5T
DSSTox ID:DTXSID6023496
ATC Code:N04BC05|N - Nervous system
HScode:2934999090
Categories:
Characteristics-
PSA:
79.2
XLogP3:1.9
Appearance:Solid
Density:1.17±0.1 g/cm3(Predicted)
Melting Point:288-290°C
Boiling Point:378°C
Flash Point:182.4±27.9 °C
Refractive Index:1.583
Water Solubility:1.40e-01 g/L
Storage Conditions:-20°C Freezer
Vapor Pressure:1.55X10-5 mm Hg at 25 deg C (est)
PKA:5.6, 9.5
Henrys Law Constant:Henry's Law constant = 5.1X10-13 atm-cu m/mol at 25 °C (est)
Dissociation Constants:5.6, 9.5|pKa1 = 4.65 (imine); pKa2 = 10.31 (secondary amine); pKa3 = 17.66 (primary amine) (est)
Experimental Properties:White to off-white powder, mp 296-301 °C (decomposes). Specific optical rotation: -67.2 deg at 20 °C/D(c = 1 in methanol). Solubility: water >20%; methanol ~8 %; ethanol ~0.5%. Practically insoluble in dichloromethane. /Pramipexole dihydrochloride monohydrate/|Hydroxyl radical reaction rate constant = 1.1X10-10 cu cm/molec-sec at 25 °C (est)
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Skin sensitization, Category 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3
GHS label elements, including precautionary statements
Pictogram(s)
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
H317 May cause an allergic skin reaction
H412 Harmful to aquatic life with long lasting effects
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P273 Avoid release to the environment.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P333+P317 If skin irritation or rash occurs: Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524
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Location:
RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA
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Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7 days
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Total Annual Revenue:
$1 million-$2.5 million
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Total Employees:
11-50
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Year of Establishment:
2022
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted
United States
Pramipexole
1 KG Nov 29, 2024 Post an enquiry for this product
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