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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Pramipexole for Sale > Pramipexole CAS 104632-26-0 Dopamine D2/D3 Receptor Agonist for Parkinson's Disease Research hfd
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Pramipexole CAS 104632-26-0 Dopamine D2/D3 Receptor Agonist for Parkinson's Disease Research  hfd buy - image1
Pramipexole CAS 104632-26-0 Dopamine D2/D3 Receptor Agonist for Parkinson's Disease Research  hfd buy - image2
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Pramipexole CAS 104632-26-0 Dopamine D2/D3 Receptor Agonist for Parkinson's Disease Research hfd

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Unit Price:

$90-117/G FOB

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CAS No.:

104632-26-0

Grade:

Reagent Grade

Content:

99%

Port:

qingdao

Brand:

//

Packaging:

5g, 25g, 100g, 500g

Price valid (until):

2026-09-27

Company Type:
Trader
Location:
China
Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance
Average Lead Time:
7 days
Qualification:
Main Products:

Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

  • Product Description

  • Seller Information

  • Inquiry History

  • Description

    —— Product Specification ——

    Parameter Specification Details
    Product Name Pramipexole (S)-N6-Propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine
    CAS Number 104632-26-0 104632-26-0
    Molecular Formula C₁₀H₁₇N₃S
    Molecular Weight 211.33 g/mol
    Appearance White to off-white crystalline powder
    Purity ≥98.0% Determined by HPLC 
    Melting Point 127 – 128°C (free base)
    Optical Rotation -93.85° (c=1, MeOH)
    Solubility DMSO: 42 mg/mL; Ethanol: 42 mg/mL; Water: Insoluble
    EC₅₀ (D3 Receptor) 1.5 nM (human)
    EC₅₀ (D2 Receptor) 5 nM (human)
    Storage -20°C, sealed, inert atmosphere, protect from light
    Packaging 10mg, 25mg, 50mg, 100mg, 500mg, 1g, 5g Amber glass vials
    Application Research use only Neuroscience research, dopamine receptor studies


    —— Product Detail ——

    Product Overview

    • Pramipexole (CAS 104632-26-0) is a synthetic non-ergoline dopamine agonist with high affinity and selectivity for dopamine D₂ and D₃ receptors. It appears as a white to off-white crystalline powder with the molecular formula C₁₀H₁₇N₃S and a molecular weight of 211.33 g/mol . This product is the free base form of pramipexole, suitable for research applications. The commercially available pharmaceutical form is typically the dihydrochloride monohydrate salt (CAS 191217-81-9), while this product is the active parent compound for research purposes


    Packaging & Shipping

                  • Research quantities: 5mg, 10mg, 25mg amber glass vials

                  • Bulk quantities: 50mg, 100mg amber glass bottles

                  • Custom packaging available upon request

                  • Not classified as hazardous material for transport under normal conditions

                  • Product for research and analytical use only; not for human therapeutic use

    Shop CAS 18048-64-1 Eltrombopag Intermediate for Pharmaceutical Research  kr-Detailed Image 1

    — Company profile ——


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    Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

    Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

    We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

    To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

    Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

     

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    —— Q&A ——

    Q1: How to confirm the product quality before placing orders?
    A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

    Q2: Can you supply free samples?
    A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

    Q3: How do you treat quality complaints?
    A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

    Q4: What is your MOQ? Is there a discount?
    A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
    Q: Is there a discount?
    A: Yes, for larger quantities, we always support with better prices.

    Q5: How to start orders or make payments?
    A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.



    ECHEMI Editorial Reference
    Off-White SolidChEBI: A member of the class of benzothiazoles that is 4,5,6,7-tetrahydro-1,3-benzothiazole in which the hydrogens at the 2 and 6-pro-S-positions are substituted by amino and propylamino groups, respectively.
    Solid
    Pramipexole is a member of the class of benzothiazoles that is 4,5,6,7-tetrahydro-1,3-benzothiazole in which the hydrogens at the 2 and 6-pro-S-positions are substituted by amino and propylamino groups, respectively. It has a role as an antiparkinson drug, a dopamine agonist, an antidyskinesia agent and a radical scavenger. It is a member of benzothiazoles and a diamine. It is a conjugate base of a pramipexole(2+).|Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD). It is a non-ergot dopamine agonist drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement). It was first approved by the FDA in 1997. Parkinson's Disease is one of the most common neurodegenerative disorders and causes a high level of disability in patients, leading to increased difficulty in performing activities of daily living due to symptoms that progress over time. The prevalence of Parkinson's Disease worldwide has increased from approximately 2.5 million in 1990 to about 6.1 million in 2016. This increase may be attributed to an aging population along with other contributing factors. In addition to the above FDA approval for Parkinson's Disease, pramipexole was also approved by the FDA in 2006 for the treatment of Restless Legs Syndrome (RLS). RLS is a sleep-related disorder characterized by unpleasant sensations in the lower extremities, often accompanied by an uncontrollable urge to move the legs.|Pramipexole is a Nonergot Dopamine Agonist. The mechanism of action of pramipexole is as a Dopamine Agonist.|Pramipexole is a selective dopamine receptor agonist used in the therapy of Parkinson disease. Pramipexole therapy is associated with a low rate of transient serum enzyme elevations during treatment, but has not been implicated in cases of clinically apparent acute liver injury.|A benzothiazole derivative and dopamine agonist with antioxidant properties that is used in the treatment of PARKINSON DISEASE and RESTLESS LEGS SYNDROME.

    Certificates
    • Pramipexole CAS 104632-26-0 Dopamine D2/D3 Receptor Agonist for Parkinson's Disease Research  hfd Certificates 1 TDS

    Basic Info
    Product Name:

    Pramipexole

    Other Name:

    2,6-Benzothiazolediamine,4,5,6,7-tetrahydro-N6-propyl-,(6S)-;2,6-Benzothiazolediamine,4,5,6,7-tetrahydro-N6-propyl-,(S)-;(6S)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine;Pramipexole;SND 919;SUD 919CL2Y;U 98528E;(-)-Pramipexole;(S)-2-Amino-6-propylamino-4,5,6,7-tetrahydrobenzothiazole;(S)-Pramipexole;6-Propylamino-4,5,6,7-tetrahydro-1,3-benzothiazole-2-amine;(6S)-N6-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine;(6S)-6-N-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine

    CAS No.:

    104632-26-0

    Molecular Formula:

    C10H17N3S

    InChIKeys:

    InChIKey=FASDKYOPVNHBLU-ZETCQYMHSA-N

    Molecular Weight:

    211.33

    Exact Mass:

    211.33

    EC Number:

    1806241-263-5

    UNII:

    83619PEU5T

    DSSTox ID:

    DTXSID6023496

    ATC Code:

    N04BC05|N - Nervous system

    HScode:

    2934999090

    Characteristics
    PSA:

    79.2

    XLogP3:

    1.9

    Appearance:

    Solid

    Density:

    1.17±0.1 g/cm3(Predicted)

    Melting Point:

    288-290°C

    Boiling Point:

    378°C

    Flash Point:

    182.4±27.9 °C

    Refractive Index:

    1.583

    Water Solubility:

    1.40e-01 g/L

    Storage Conditions:

    -20°C Freezer

    Vapor Pressure:

    1.55X10-5 mm Hg at 25 deg C (est)

    PKA:

    5.6, 9.5

    Henrys Law Constant:

    Henry's Law constant = 5.1X10-13 atm-cu m/mol at 25 °C (est)

    Dissociation Constants:

    5.6, 9.5|pKa1 = 4.65 (imine); pKa2 = 10.31 (secondary amine); pKa3 = 17.66 (primary amine) (est)

    Experimental Properties:

    White to off-white powder, mp 296-301 °C (decomposes). Specific optical rotation: -67.2 deg at 20 °C/D(c = 1 in methanol). Solubility: water >20%; methanol ~8 %; ethanol ~0.5%. Practically insoluble in dichloromethane. /Pramipexole dihydrochloride monohydrate/|Hydroxyl radical reaction rate constant = 1.1X10-10 cu cm/molec-sec at 25 °C (est)

    Hazard Identification

    Classification of the substance or mixture

    Acute toxicity - Category 4, Oral

    Skin sensitization, Category 1

    Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 3

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Warning

    Hazard statement(s)

    H302 Harmful if swallowed

    H317 May cause an allergic skin reaction

    H412 Harmful to aquatic life with long lasting effects

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P272 Contaminated work clothing should not be allowed out of the workplace.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    P273 Avoid release to the environment.

    Response

    P301+P317 IF SWALLOWED: Get medical help.

    P330 Rinse mouth.

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P333+P317 If skin irritation or rash occurs: Get medical help.

    P321 Specific treatment (see ... on this label).

    P362+P364 Take off contaminated clothing and wash it before reuse.

    Storage

    none

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

    Location:

    RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA

    Payment Terms:

    TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7 days

    Total Annual Revenue:

    $1 million-$2.5 million

    Total Employees:

    11-50

    Year of Establishment:

    2022

    Jinan Topfull Chemical Co., Ltd. is a global chemical Industrial and focuses on advanced chemical technology. Specialized in Cosmetic materials, water treatment, fine chemicals and so on. We are looking forward to working together with the people of all circles at home and abroad to seek common development!
  • Inquiry History
    1 Inquiries
    Country Product Purchase Quantity Date Posted
    United States

    Pramipexole

    1 KG Nov 29, 2024
    Post an enquiry for this product
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