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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Nexavar for Sale > Sorafenib Tosylate CAS 475207-59-1 Multikinase Inhibitor for Renal Cell and Hepatocellular Carcinoma Research hfd
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Sorafenib Tosylate CAS 475207-59-1 Multikinase Inhibitor for Renal Cell and Hepatocellular Carcinoma Research hfd

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Unit Price:

$100-130/G FOB

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CAS No.:

475207-59-1

Grade:

Reagent Grade

Content:

99%

Port:

qingdao

Brand:

//

Packaging:

5g, 25g, 100g, 500g

Price valid (until):

2026-09-29

Company Type:
Trader
Location:
China
Qualification:
Main Products:

Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

  • Product Description

  • Seller Information

  • Inquiry History

  • Description

    —— Product Specification ——

    Parameter Specification Details
    Product Name Sorafenib Tosylate BAY 43-9006; Nexavar 
    CAS Number 475207-59-1 475207-59-1 
    Molecular Formula C₂₁H₁₆ClF₃N₄O₃·C₇H₈O₃S C28H24ClF3N4O6S 
    Molecular Weight 637.03 g/mol — 
    Appearance White to light yellow powder to crystal Visual inspection 
    Purity ≥98.0% Determined by HPLC and titration 
    Melting Point 222.0 – 226.0°C — 
    Solubility Soluble in DMSO; poorly soluble in water  —
    IC₅₀ (Raf-1) 6 nM Potent Raf kinase inhibition 
    IC₅₀ (B-Raf) 20 nM — 
    IC₅₀ (VEGFR2) 90 nM Multikinase inhibition 
    IC₅₀ (VEGFR3) 15 nM — 
    IC₅₀ (PDGFRβ) 57 nM — 
    IC₅₀ (c-Kit) 68 nM — 
    Storage 0-10°C (refrigerated), under inert gas Air and heat sensitive; protect from moisture 
    Packaging 5mg, 10mg, 25mg, 50mg, 100mg, 500mg, 1g Amber glass vials
    Application Research use only Oncology research, kinase inhibition studies


    —— Product Detail ——

    Product Overview

    • Sorafenib Tosylate (CAS 475207-59-1), also known as BAY 43-9006 and marketed under the brand name Nexavar, is the tosylate salt of sorafenib, an orally active multikinase inhibitor with potent antitumor activity . It appears as a white to light yellow powder to crystal with the molecular formula C28H24ClF3N4O6S and a molecular weight of 637.03 g/mol


    Packaging & Shipping

                  • Research quantities: 5mg, 10mg, 25mg amber glass vials

                  • Bulk quantities: 50mg, 100mg amber glass bottles

                  • Custom packaging available upon request

                  • Not classified as hazardous material for transport under normal conditions

                  • Product for research and analytical use only; not for human therapeutic use

    Shop CAS 18048-64-1 Eltrombopag Intermediate for Pharmaceutical Research  kr-Detailed Image 1

    — Company profile ——


     Shop CAS 1231930-42-9 Abemaciclib Intermediate for Pharma researech use KR-Detailed Image 1

    Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

    Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

    We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

    To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

    Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

     

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    —— Q&A ——

    Q1: How to confirm the product quality before placing orders?
    A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

    Q2: Can you supply free samples?
    A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

    Q3: How do you treat quality complaints?
    A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

    Q4: What is your MOQ? Is there a discount?
    A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
    Q: Is there a discount?
    A: Yes, for larger quantities, we always support with better prices.

    Q5: How to start orders or make payments?
    A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.



    ECHEMI Editorial Reference
    Sorafenib tosylate is a potent multikinase inhibitor, with IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.
    Sorafenib tosylate is an organosulfonate salt. It contains a sorafenib.|Sorafenib Tosylate is the tosylate salt of sorafenib, a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis.|A niacinamide and phenylurea derivative that inhibits multiple intracellular and cell surface kinases thought to be involved in ANGIOGENESIS, including RAF KINASES and VEGF RECEPTORS. It is used in the treatment of advanced RENAL CELL CARCINOMA and HEPATOCELLULAR CARCINOMA, and for treatment of THYROID CARCINOMA refractory to radioactive iodine therapy.

    Certificates
    • Sorafenib Tosylate CAS 475207-59-1 Multikinase Inhibitor for Renal Cell and Hepatocellular Carcinoma Research hfd Certificates 1 TDS

    Basic Info
    Product Name:

    Nexavar

    Other Name:

    2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-,4-methylbenzenesulfonate (1:1);2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-,mono(4-methylbenzenesulfonate);BAY 43-9006 mono-p-tosylate;Sorafenib tosylate;Nexavar;BAY 54-9085;Sorafenib p-toluenesulfonate

    CAS No.:

    475207-59-1

    Molecular Formula:

    C21H16ClF3N4O3.C7H8O3S

    InChIKeys:

    InChIKey=IVDHYUQIDRJSTI-UHFFFAOYSA-N

    Molecular Weight:

    637.027

    Exact Mass:

    636.105713

    UNII:

    5T62Q3B36J

    NSC Number:

    724772

    DSSTox ID:

    DTXSID9047839

    NCI Thesaurus Code:

    C2194

    ATC Code:

    L01EX02

    HScode:

    29159000

    Characteristics
    PSA:

    155

    XLogP3:

    8.40910

    Appearance:

    White to off-white crystalline powder

    Density:

    1.454 g/cm3

    Boiling Point:

    523.3ºC at 760 mmHg

    Flash Point:

    270.3ºC

    Hazard Identification

    Classification of the substance or mixture

    Reproductive toxicity, Category 1B

    Specific target organ toxicity – repeated exposure, Category 2

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H360 May damage fertility or the unborn child

    H373 May cause damage to organs through prolonged or repeated exposure

    Precautionary statement(s)
    Prevention

    P203 Obtain, read and follow all safety instructions before use.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    P260 Do not breathe dust/fume/gas/mist/vapours/spray.

    Response

    P318 IF exposed or concerned, get medical advice.

    P319 Get medical help if you feel unwell.

    Storage

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

    Location:

    RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA

    Payment Terms:

    TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7

    Total Annual Revenue:

    $1 million-$2.5 million

    Total Employees:

    11-50

    Year of Establishment:

    2022

    Jinan Topfull Chemical Co., Ltd. is a global chemical Industrial and focuses on advanced chemical technology. Specialized in Cosmetic materials, water treatment, fine chemicals and so on. We are looking forward to working together with the people of all circles at home and abroad to seek common development!
  • Inquiry History
    1 Inquiries
    Country Product Purchase Quantity Date Posted
    Bangladesh

    Sorafenib Tosylate

    1 MT Sep 9, 2024
    Post an enquiry for this product
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