Sorafenib Tosylate
1 Inquiries
475207-59-1
99%
2026-06-30
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Inquiry History
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Description
ProductName Sorafenib Tosylate Cat No CEI-0163 Description Sorafenib (BAY 43-9006, Nexavar) can inhibit VEGFR2, VEGFR3, PDGFR-beta, FLT-3 and c-kit with IC50 of 90 nM, 15 nM, 20nM, 57nM and 58 nM. Alias Bay 43-9006 CAS No 475207-59-1 Molecular Weight 637.03 Purity >99% Storage 2 years at -20centigrade Powder Synonyms Bay 43-9006 Targets VEGFR2/VEGFR3, PDGFR-beta, FLT-3, c-kit, Raf/B-raf(WT)/B-raf(V599E) Molecular Formula C21H16CLF3N4O3.C7H803S Chemical Name 2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-, 4-methylbenzenesulfonate (1:1) Solubility DMSO 127 mg/mL Water In vitro Sorafenib (BAY 43-9006, Nexavar) shows inhibition to many kinases including VEGFR, PDFGR, Raf, FLT-3, Ret, and c-Kit. Sorafenib (BAY 43-9006, Nexavar) can inhibit VEGFR2, VEGFR3, PDGFR-beta, FLT-3 and c-kit with IC50 of 90 nM, 15 nM, 20nM, 57nM and 58 nM. Actually, Sorafenib (BAY 43-9006, Nexavar) is a strong Raf inhibitor which can inhibit Raf, B-raf (Wt), and B-raf (V599E) with IC50 of 6nM, 22 nM and 38 nM. Sorafenib (BAY 43-9006, Nexavar) shows its influence on RAS-MAPK signaling cascade and it can inhibit MEK and ERK weekly with IC50 more than 10 uM. Sorafenib (BAY 43-9006, Nexavar) induces mitochondrial cytochrome c and SMAC release and PARP cleavage in A375, A 2058, and SKMEL5 melanoma cells. Sorafenib (BAY 43-9006, Nexavar) also induces mitochondrial release and nuclear translocation of AIF. in sensitive cell lines, BAY 43-9006-induced apoptosis is independent of Bad dephosphorylation and caspase activation and largely mediated through the nuclear translocation of AIF. Sorafenib shows great inhibition to cell lines including hepatocellular carcinoma and renal cell carcinoma.In recent research, sorafenib shows antitumor efficacy to many types of cells including metastatic thyroid cancer cells, human neuroblastoma cells. In vivo Orally administered BAY 43-9006 in a representative panel of tumor xenograft models shows antitumor efficacy. Mice bearing 75 to 150 mg tumors were treated orally with BAY 43-9006 at dose levels of 7.5 to 60 mg/kg, administered daily for 9 days. During treatment with 30 to 60 mg/kg BAY 43-9006, complete tumor stasis in the HT-29, Colo-205, and DLD-1 human colon tumor models and the A549 NSCLC model was observed). Each of these tumor lines expresses a mutation in either KRAS or BRAF that would constitutively activate signaling through the RAF/MEK/ERK pathway. In another NSCLC model (NCI-H460) tumor growth was inhibited, but complete stasis during treatment was not achieved at doses up to 60 mg/kg. category Circulatory System Drugs(c1427) cas_num 475207-59-1 Basic Info-
Product Name:
Nexavar
Other Name:2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-,4-methylbenzenesulfonate (1:1);2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-,mono(4-methylbenzenesulfonate);BAY 43-9006 mono-p-tosylate;Sorafenib tosylate;Nexavar;BAY 54-9085;Sorafenib p-toluenesulfonate
CAS No.:475207-59-1
Molecular Formula:C21H16ClF3N4O3.C7H8O3S
InChIKeys:InChIKey=IVDHYUQIDRJSTI-UHFFFAOYSA-N
Molecular Weight:637.027
Exact Mass:636.105713
UNII:5T62Q3B36J
NSC Number:724772
DSSTox ID:DTXSID9047839
NCI Thesaurus Code:C2194
ATC Code:L01EX02
HScode:29159000
Categories:
Characteristics-
PSA:
155
XLogP3:8.40910
Appearance:White to off-white crystalline powder
Density:1.454 g/cm3
Boiling Point:523.3ºC at 760 mmHg
Flash Point:270.3ºC
Hazard IdentificationClassification of the substance or mixture
Reproductive toxicity, Category 1B
Specific target organ toxicity â repeated exposure, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H360 May damage fertility or the unborn child
H373 May cause damage to organs through prolonged or repeated exposure
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response P318 IF exposed or concerned, get medical advice.
P319 Get medical help if you feel unwell.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
Bangladesh
Sorafenib Tosylate
1 MT Sep 9, 2024 Post an enquiry for this product