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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Resmetirom for Sale > Resmetirom CAS 920509-32-6 Selective THR-β Agonist for MASH and Metabolic Research kr
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Resmetirom CAS 920509-32-6 Selective THR-β Agonist for MASH and Metabolic Research kr

TDS 5 Inquiries

Unit Price:

$100-130/G FOB

Get Latest Price
CAS No.:

920509-32-6

Grade:

Reagent Grade

Content:

99%

Port:

qingdao

Brand:

//

Packaging:

5g, 25g, 100g, 500g

Price valid (until):

2026-10-01

Company Type:
Trader
Location:
China
Qualification:
Main Products:

Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

  • Product Description

  • Seller Information

  • Inquiry History

  • Description

    —— Product Specification ——

    Parameter Specification Details
    Product Name Resmetirom MGL-3196; VIA-3196
    CAS Number 920509-32-6 920509-32-6 
    Molecular Formula C₁₇H₁₂Cl₂N₆O₄ — 
    Molecular Weight 435.22 g/mol — 
    Appearance White to off-white solid powder Visual inspection
    Purity ≥98.0% Determined by HPLC
    EC₅₀ (THR-β) 0.21 μM Cell-free assay, 28-fold selective over THR-α 
    Solubility Soluble in DMSO
    Storage -80°C for long-term; sealed containers Protect from moisture and light; cold chain shipping required 
    Application Research use only Metabolic research, MASH studies, reference standard


    —— Product Detail ——

    Product Overview

    • Resmetirom (CAS 920509-32-6), also known as MGL-3196 or VIA-3196, is a first-in-class, liver-directed, orally active, selective thyroid hormone receptor beta (THR-β) agonist . It appears as a white to off-white solid powder with the molecular formula C₁₇H₁₂Cl₂N₆O₄ and a molecular weight of 435.22 g/mol . The compound was developed as a lipid-lowering agent and later repurposed for metabolic dysfunction-associated steatohepatitis (MASH), becoming the first FDA-approved therapy for this indication


    Packaging & Shipping

                  • Research quantities: 5mg, 10mg, 25mg amber glass vials

                  • Bulk quantities: 50mg, 100mg amber glass bottles

                  • Custom packaging available upon request

                  • Not classified as hazardous material for transport under normal conditions

                  • Product for research and analytical use only; not for human therapeutic use

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    Company profile ——


     Shop CAS 1231930-42-9 Abemaciclib Intermediate for Pharma researech use KR-Detailed Image 1

    Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

    Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

    We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

    To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

    Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

     

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    —— Q&A ——

    Q1: How to confirm the product quality before placing orders?
    A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

    Q2: Can you supply free samples?
    A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

    Q3: How do you treat quality complaints?
    A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

    Q4: What is your MOQ? Is there a discount?
    A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
    Q: Is there a discount?
    A: Yes, for larger quantities, we always support with better prices.

    Q5: How to start orders or make payments?
    A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.



    ECHEMI Editorial Reference
    MGL-3196 has been used in trials studying the treatment of Non-alcoholic steatohepatitis and Heterozygous Familial Hypercholesterolemia.
    MGL-3196 is an agonist of thyroid hormone receptor β (TRβ; EC50s = 0.21 and 3.74 μM for TRβ and TRα, respectively). It also inhibits ether-a-go-go-related gene (ERG) potassium channels (IC50= 30 μM). MGL-3196 is a liver-directed compound, with a liver to plasma ratio of 8:1 in mice with diet-induced obesity (DIO), which reduces the likelihood of adverse effects from systemic exposure. It does not affect the expression of α-myosin heavy chain (α-MHC) in a rat model of hypothyroidism, an effect mediated by TRα, indicating low potential for cardiac adverse effects. MGL-3196 lowers non-HDL cholesterol and liver triglycerides without affecting thyroid stimulating hormone (Tsh) levels in rat and rabbit models of hypercholesterolemia. It also lowers plasma glucose levels and improves insulin sensitivity in DIO mice. Formulations containing MGL-3196 are in clinical trials for the treatment of non-alcoholic steatohepatitis (NASH) and familial hypercholesterolemia.

    Certificates
    • Resmetirom CAS 920509-32-6 Selective THR-β Agonist for MASH and Metabolic Research kr Certificates 1 TDS

    Basic Info
    Product Name:

    Resmetirom

    Other Name:

    Resmetirom (MGL-3196,VIA-3196);MGL-3196; MGL 3196; MGL3196; VIA-3196; VIA3196; VIA-3196;VIA3196;VIA-3196;MGL-3196;Resmetirom;2-[3,5-Dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triazine-6-carbonitrile;CS-2429

    CAS No.:

    920509-32-6

    Molecular Formula:

    C17H12Cl2N6O4

    InChIKeys:

    FDBYIYFVSAHJLY-UHFFFAOYSA-N

    Molecular Weight:

    435.22

    Exact Mass:

    434.0297083

    UNII:

    RE0V0T1ES0

    Color/Form:

    Yellow to orange

    Characteristics
    Density:

    1.65±0.1 g/cm3(Predicted)

    PKA:

    3.96±0.40(Predicted)

    Critical Temperature & Pressure:

    Inert atmosphere,Store in freezer, under -20°C

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

    Location:

    RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA

    Payment Terms:

    TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7

    Total Annual Revenue:

    $1 million-$2.5 million

    Total Employees:

    11-50

    Year of Establishment:

    2022

    Jinan Topfull Chemical Co., Ltd. is a global chemical Industrial and focuses on advanced chemical technology. Specialized in Cosmetic materials, water treatment, fine chemicals and so on. We are looking forward to working together with the people of all circles at home and abroad to seek common development!
  • Inquiry History
    5 Inquiries
    Country Product Purchase Quantity Date Posted
    India

    Resmetirom

    100 G Aug 20, 2025
    United States

    Resmetirom

    1 KG Jun 4, 2026
    Pakistan

    Resmetirom

    20 KG Jan 3, 2025
    United States

    Resmetirom

    1 KG Dec 10, 2024
    India

    Resmetirom

    5 G Aug 18, 2026
    Post an enquiry for this product
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