Resmetirom CAS 920509-32-6 Selective THR-β Agonist for MASH and Metabolic Research kr
TDS 5 Inquiries
920509-32-6
Reagent Grade
99%
qingdao
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5g, 25g, 100g, 500g
2026-10-01
Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceMGL-3196 has been used in trials studying the treatment of Non-alcoholic steatohepatitis and Heterozygous Familial Hypercholesterolemia.
MGL-3196 is an agonist of thyroid hormone receptor β (TRβ; EC50s = 0.21 and 3.74 μM for TRβ and TRα, respectively). It also inhibits ether-a-go-go-related gene (ERG) potassium channels (IC50= 30 μM). MGL-3196 is a liver-directed compound, with a liver to plasma ratio of 8:1 in mice with diet-induced obesity (DIO), which reduces the likelihood of adverse effects from systemic exposure. It does not affect the expression of α-myosin heavy chain (α-MHC) in a rat model of hypothyroidism, an effect mediated by TRα, indicating low potential for cardiac adverse effects. MGL-3196 lowers non-HDL cholesterol and liver triglycerides without affecting thyroid stimulating hormone (Tsh) levels in rat and rabbit models of hypercholesterolemia. It also lowers plasma glucose levels and improves insulin sensitivity in DIO mice. Formulations containing MGL-3196 are in clinical trials for the treatment of non-alcoholic steatohepatitis (NASH) and familial hypercholesterolemia.Certificates-
TDS
Basic Info-
Product Name:
Resmetirom
Other Name:Resmetirom (MGL-3196,VIA-3196);MGL-3196; MGL 3196; MGL3196; VIA-3196; VIA3196; VIA-3196;VIA3196;VIA-3196;MGL-3196;Resmetirom;2-[3,5-Dichloro-4-[[1,6-dihydro-5-(1-methylethyl)-6-oxo-3-pyridazinyl]oxy]phenyl]-2,3,4,5-tetrahydro-3,5-dioxo-1,2,4-triazine-6-carbonitrile;CS-2429
CAS No.:920509-32-6
Molecular Formula:C17H12Cl2N6O4
InChIKeys:FDBYIYFVSAHJLY-UHFFFAOYSA-N
Molecular Weight:435.22
Exact Mass:434.0297083
UNII:RE0V0T1ES0
Color/Form:Yellow to orange
Categories:
Characteristics-
Density:
1.65±0.1 g/cm3(Predicted)
PKA:3.96±0.40(Predicted)
Critical Temperature & Pressure:Inert atmosphere,Store in freezer, under -20°C
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Seller Information
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Business Type:
Trader
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Main Products:
Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524
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Location:
RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA
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Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7
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Total Annual Revenue:
$1 million-$2.5 million
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Total Employees:
11-50
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Year of Establishment:
2022
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Inquiry History5 Inquiries
Country Product Purchase Quantity Date Posted
India
Resmetirom
100 G Aug 20, 2025
United States
Resmetirom
1 KG Jun 4, 2026
Pakistan
Resmetirom
20 KG Jan 3, 2025
United States
Resmetirom
1 KG Dec 10, 2024
India
Resmetirom
5 G Aug 18, 2026 Post an enquiry for this product