p-Toluenesulfonic Acid Monohydrate 98% Purity CAS 6192-52-5 Reagent Grade Organic Acid Catalyst for Chemical Synthesis and Pharmaceutical Intermediate

Product Overview

p‑Toluenesulfonic acid monohydrate (CAS 6192‑52‑5) is a white crystalline organic acid widely used as a catalyst in organic synthesis. It is one of the most commonly employed solid acids in pharmaceutical and chemical manufacturing due to its strong acidity, good solubility in organic solvents, and ease of handling. Its pKa value in water is approximately -2.8, making it a strong acid comparable to mineral acids, yet it remains non-oxidizing and compatible with most functional groups. This reagent-grade product is supplied at ≥98% purity and is a versatile catalyst for esterification, transesterification, acetalization, and other acid-catalyzed reactions.

Synthetic Process

p‑Toluenesulfonic acid is typically synthesized by the sulfonation of toluene with concentrated sulfuric acid, followed by crystallization and purification to obtain the monohydrate form. The product is carefully dried to maintain the appropriate water content (7.0‑9.0%) characteristic of the monohydrate.

Mechanism of Action / Application Principles

As an acid catalyst, p‑toluenesulfonic acid functions through:

• Proton Donation: The sulfonic acid group readily donates a proton to substrates, activating carbonyl groups for nucleophilic attack, facilitating esterification and condensation reactions.

• Stable Counterion: The sulfonate anion is a stable, non‑nucleophilic counterion that does not interfere with subsequent reaction steps, making it ideal for reactions requiring a strong acid without unwanted side reactions.

• Selective Acetalization: Its strong acidity enables the selective protection of diols and carbonyl compounds under mild conditions.

• Deprotection Agent: It is commonly used for the cleavage of tert‑butyl ethers, te

  Packaging & Shipping

  • Packaging: Available in 100g and 500g laboratory bottles, and 25kg bags.

  • Shipping: This product is classified as a corrosive solid. Store in a cool, dry place away from bases and oxidizing agents.

  rt‑butoxycarbonyl (Boc) groups, and other protecting groups in peptide and organic synthesis.

  Quality Specifications

  
  

  
  

  Parameter	Specification	Test Method
  Appearance	White crystalline solid	Visual inspection
  Assay (Purity)	≥98.0%	Titration
  Water Content	7.0‑9.0%	Karl Fischer titration
  Residue on Ignition	≤0.05%	Gravimetric analysis
  Melting Point	103‑105°C	Capillary method

  
  

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

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