 Home > Biochemical Engineering > Plant Extracts > Flibanserin for Sale > Flibanserin167933-07-5C20H21F3N4O

Flibanserin167933-07-5C20H21F3N4O buy - large image1

Flibanserin167933-07-5C20H21F3N4O buy - image1

Flibanserin167933-07-5C20H21F3N4O buy - image2

Flibanserin167933-07-5C20H21F3N4O buy - image3

Flibanserin167933-07-5C20H21F3N4O buy - image4

Flibanserin167933-07-5C20H21F3N4O

Name: Flibanserin167933-07-5C20H21F3N4O
Brand: OORENT
SKU: pr2609031203
Price: 33 USD
Availability: InStock

14 Inquiries

Unit Price:

$33-34/MT FOB

Get Latest Price 

CAS No.:

167933-07-5

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

shanghai

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Sample Available:

Yes

Price valid (until):

2026-10-03

Contact Supplier

 Chat Now

Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Payment Terms:

100% TT in advance

Average Lead Time:

10 days

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

 Visit Store

Product Description
Seller Information
Inquiry History

Description

Product Detail

TETRAPOTASSIUM HEXACYANOFERRATE Basic information

Flibanserin Basic information

description Uses Application Mechanism of action Drugs for enhancing female sexuality

Product Name:	Flibanserin
Synonyms:	Niemunerkeine;3-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-1H-benzimidazol-2-one;Flibaneserin;BIMT-17;BIMT-17BS;Flubensin (female);Flibaserin(female);Fbanselin;Flubanserin
CAS:	167933-07-5
MF:	C20H21F3N4O
MW:	390.4
EINECS:	643-002-2
Product Categories:	API;API,chemical material;1
Mol File:	167933-07-5.mol

Flibanserin Chemical Properties

density	1.292±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: soluble10mg/mL, clear
form	powder
pka	12.12±0.30(Predicted)
color	white to beige
InChI	InChI=1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12-26)10-13-27-18-7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28)
InChIKey	PPRRDFIXUUSXRA-UHFFFAOYSA-N
SMILES	C1(=O)N(CCN2CCN(C3=CC=CC(C(F)(F)F)=C3)CC2)C2=CC=CC=C2N1

Safety Information

Hazard Codes	T
Risk Statements	25-36/37/38
Safety Statements	26-45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	3
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 3 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3
Hazardous Substances Data	167933-07-5(Hazardous Substances Data)

MSDS Information

Flibanserin Usage And Synthesis

description	Flibanserin (Addyi-Sprout Pharmaceuticals) is a first-in-class oral medication approved by FDA for the treatment of acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women. Although it meets the need for drugs that address women's sexual function, flibanserin is unlike agents that treat erectile dysfunction, as it is intended to increase sexual desire, not performance. Flibanserin is the first prescription medicine for the treatment of this sexual dysfunction. The FDA approval is not without warnings; flibanserin is subject to the Risk Evaluation and Mitigation Strategy (REMS) to ensure safe use by patients, and has a boxed warning directed to prescribing providers. The goal is to inform patients and providers of the increased risk of hypotension and syncope (Vallejos 2017).
Uses	Filbanserin is an agonist of serotonin-5HT1A receptor and an antagonist of the 5-HT2A receptor. Binds dopamine receptors with Ki values ranging from 4-24 nM. Used to treat hypoactive sexual desire disorder in females.
Application	Flibanserin is an N-alkylpiperazine that is 1-[2-(1,3-dihydro-2-oxobenzimidazol-1-yl)ethyl]piperazine in which the remaining amino proton is replaced by a 3-(trifluoromethyl)phenyl group. A multifunctional serotonin agonist and antagonist which is used for the treatment of pre-menopausal women with hypoactive sexual desire disorder. Flibanserin has a role as a serotonergic agonist, a serotonergic antagonist and an antidepressant. Flibanserin is a member of benzimidazoles, a N-arylpiperazine, a N-alkylpiperazine and an organofluorine compound.
Mechanism of action	Flibanserin is a novel multifunctional serotonin agonist and antagonist (MSAA) that improves sexual functioning in premenopausal women who suffer from reduced sexual interest and desire.Flibanserin theoretically improves sexual functioning by enhancing downstream release of dopamine and norepinephrine while reducing serotonin release in the brain circuits that mediate symptoms of reduced sexual interest and desire. Flibanserin has demonstrated clinical efficacy in premenopausal women who have reduced interest in and desire for sex and has 2 principal pharmacologic actions in microcircuits: it is a full agonist at postsynaptic serotonin 5HT1A receptors and an antagonist at postsynaptic 5HT2A receptors..Flibansetrin has high affinity for serotonin receptors in the brain: it acts as an agonist on 5-HT1A and an antagonist on 5-HT2A. In vivo, flibanserin binds equally to 5-HT1A and 5-HT2A receptors.
Drugs for enhancing female sexuality	Flibanserin is the world's first New drug for enhancing female sexuality. It can reduce the amount of 5-hydroxytryptamine which inhibits sexuality and improve sexual stimulant dopamine levels. It is already submitted to Food and Drug Administration of the United States for approval. This drug can directly effect on the sexual pleasure control area of the female brain to restore female Flagging libido. By adjusting the aphrodisiac body system, Flibanserin Helps to restore the balance of sexual appetite suppression and exciting mechanism and lead to form a healthy sexual performance. The curative effect can be obtained a few weeks later. At the same time, the female viagra also has a certain side effects. One-eighth of tested women appeared dizziness, fatigue and sleepiness. Similar to antidepressants, Flibanserin will affect the brain secretion chemicals associated with emotions and desires. In fact, it was used as a drug for the treatment of depression before before it becomes a sex medicine. Different from the working principle of "viagra", Flibanserin works by adjusting the chemicals in female brains. In addition, "viagra" only works for most men, Flibanserin has effects on women with low libido. If the patient does not have a sexual interest to someone, Flibanserin will not affect her. Flibanserin will not cause hyperaphrodisia. Clayton. Anita, adviser of the drug companies says :“it is not an aphrodisiac and it only helps to balance the chemicals in the female brain to make a female restore sex desire, but not more than the normal level. However, it takes some time for this drug to work and women should take the drug every day. Figure 1 shows Flibanserin tablet.
Description	Flibanserin is a drug originally developed by Boehringer-Ingelheim and later Sprout Pharmaceuticals, which was approved in 2015 by the FDA for the treatment of premenopausal women with hypoactive sexual desire disorder (HSDD). The drug, which was originally developed for the treatment of depression by Boehringer- Ingelheim, is a full agonist of the 5-HT1A receptor, an antagonist of the 5-HT2A receptor, and a partial agonist of the dopamine-4 (D4) receptor, which triggers increased dopamine and norepinephrine levels along with decreased serotonin levels. In three randomized trials involving 2400 premenopausal women, the drug was found to increase the number of satisfying sexual events by 0.5-1.0 events per month and increased sexual desire on average by 10-12% over placebo. Side effects include decreased blood pressure and loss of consciousness, especially in subjects who consumed alcohol.
Uses	Antidepressant (5-HT1a agonist and 5-HT2 antagonist).
Definition	ChEBI: Flibanserin is an N-alkylpiperazine that is 1-[2-(1,3-dihydro-2-oxobenzimidazol-1-yl)ethyl]piperazine in which the remaining amino proton is replaced by a 3-(trifluoromethyl)phenyl group. A multifunctional serotonin agonist and antagonist which is used for the treatment of pre-menopausal women with hypoactive sexual desire disorder. It has a role as a serotonergic agonist, a serotonergic antagonist and an antidepressant. It is a member of benzimidazoles, a N-arylpiperazine, a N-alkylpiperazine and an organofluorine compound.
Biochem/physiol Actions	Flibanserin is a 5-HT1A receptor agonist and 5-HT2A receptor antagonist. Flibanserin has high affinity for human 5-HT1A receptors (Ki = 1 nm) and lower affinity for 5-HT2A (Ki = 49 nm) and D4 (Ki = 4–24 nm) receptors, and negligible affinity for a variety of other neurotransmitter receptors and ion channels. Flibanserin was investigated as a novel, non-hormonal treatment for pre-menopausal women with Hypoactive Sexual Desire Disorder (HSDD). Flibanserin. Recently, Flibanserin was found to reduce L-DOPA-induced dyskinesia in a model of Parkinson′s Disease.
Synthesis	The large-scale synthesis of flibanserin (X) mostly follows a patent from Symed Laboratories Limited which demonstrated hundred-gram-scale preparation of the drug as described in Scheme. Starting from commercially available 1-(prop-1- en-2-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one (74), installation of an ethylene side chain was accomplished under conventional alkylation conditions with 1,2-dibromoethane and base, and this event was immediately followed by a second alkylation reaction involving piperazine to secure piperazinyl benzimidazolone 75. Interestingly, the enamine double bond within 74 was apparently reduced to the corresponding isopropyl group under these conditions. Although the authors do not comment about this reduction directly, similar examples of olefin reduction under non-hydrogenative alkylation conditions have been reported in the literature separately by both Pai and Ryu. Removal of the isopropyl group was facilitated by means of aqueous sodium hydroxide to afford 76, which underwent N-arylation under Buchwald conditions with 1-bromo-3-(trifluoromethyl)benzene 77 to furnish flibanserin (X) in 63% yield.
in vitro	previous study found that flibanserin was a 5-ht(1a) agonist, a very weak partial agonist on dopamine d(4) receptors, and a 5-ht(2a) antagonist. flibanserin could reduce neuronal firing rate and flibanserin-induced reduction in firing rate was likely mediated via stimulation of postsynaptic 5-ht(1a) receptors. moreover, flibanserin could quickly desensitize somatic 5-ht autoreceptors and enhance tonic activation of postsynaptic 5-ht(1a) receptors. in addition, flibanserin was able to reduce synthesis and extracellular levels of 5-ht in the cortex [1].
in vivo	previous animal study showd that flibanserin had antidepressant-like activity in most animal models sensitive to antidepressants, and such activity seemed different from that exerted by other antidepressants. in addition, flibanserin did not show consistent effects in animal models of anxiety and seemed to exert potential antipsychotic effects [1].
references	[1] borsini f, evans k, jason k, rohde f, alexander b, pollentier s. pharmacology of flibanserin. cns drug rev. 2002 summer;8(2):117-42. [2] katz m et al. efficacy of flibanserin in women with hypoactive sexual desire disorder: results from the begonia trial. j sex med. 2013 jul;10(7):1807-15.

Shop Tirzepatide2023788-19-2-Detailed Image 2

Shop Tirzepatide2023788-19-2-Detailed Image 3

Shop Tirzepatide2023788-19-2-Detailed Image 4

Shop Tirzepatide2023788-19-2-Detailed Image 5

Shop Tirzepatide2023788-19-2-Detailed Image 6

Shop Tirzepatide2023788-19-2-Detailed Image 7

ECHEMI Editorial Reference

Flibanserin is a novel multifunctional serotonin agonist and antagonist (MSAA) that improves sexual functioning in premenopausal women who suffer from reduced sexual interest and desire.IC50 value:Target: serotoninin vivo: The multifunctional serotonergic agent Flibanserin is both a serotonin 1A agonist and a serotonin 2A antagonist. Flibanserin theoretically improves sexual functioning by enhancing downstream release of dopamine and norepinephrine while reducing serotonin release in the

Basic Info

Product Name:

Flibanserin

Other Name:

2H-Benzimidazol-2-one,1,3-dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-;1,3-Dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-2H-benzimidazol-2-one;BIMT 17;Flibanserin;BIMT 17BS;Addyi;1-(2-[4-[3-(Trifluoromethyl)phenyl]piperazin-1-yl]ethyl)-1,3-dihydro-2H-benzimidazol-2-one

CAS No.:

167933-07-5

Molecular Formula:

C20H21F3N4O

InChIKeys:

InChIKey=PPRRDFIXUUSXRA-UHFFFAOYSA-N

Molecular Weight:

390.4

Exact Mass:

390.40

EC Number:

1806241-263-5

Categories:

Plant Extracts

Characteristics

PSA:

38.8

XLogP3:

3.3

Appearance:

white to beige

Density:

1.292 g/cm3

Refractive Index:

1.566

Water Solubility:

DMSO: soluble10mg/mL, clear

Storage Conditions:

2-8°C

Vapor Pressure:

3.13X10-10 mm Hg at 25 deg C (est)

See More Flibanserin Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Flibanserin Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

14 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Flibanserin for for Women CAS 167933-07-5	5 G	Apr 29, 2026
Malaysia	Flibanserin⁠	1 KG	Sep 2, 2026
United States	Flibanserin	10 G	Nov 28, 2024
United States	Flibanserin	3000 MG	Aug 23, 2024
Malaysia	Flibanserin	100 G	Jul 18, 2024
Mexico	Flibanserin 100mg tablets/pills	100 G	Aug 4, 2026
United Kingdom	Flibanserin for Female Sex Enhancement	10 G	Feb 6, 2026
United States	Flibanserin 99%	1 KG	Feb 2, 2026
Nigeria	flibanserin	50 KG	Nov 14, 2025
Madagascar	Flibanserin	60 G	Oct 21, 2024
Mexico	Flibanserin 100mg tablets/pills	100 G	Aug 10, 2024
Mexico	Flibanserin 100mg tablets/pills	100 G	Aug 10, 2024
Indonesia	Flibanserin 99% powder	500 G	Sep 3, 2026
Estonia	Flibanserin	10 G	Feb 26, 2024

Post an enquiry for this product

More Choices Find All Products for Sale 

Product Name	Grade / Content	Price	Supplier Name	Details
Factory Direct Supply Flibanserin Powder CAS 167933-07-5 With Good Price	Pharmaceutical Grade/99	$22-23/G FOB	NATURE INDUSTRIAL LIMITED	Inquiry
Raw Material chemicals 99% Powder SAA099894343232 SAA	Industrial Grade/99	$1550-1780/MT FOB	M A M M TRANDING ENTERPRISE	Inquiry
Flibaserin female commerial in stock	Pharmaceutical Grade/99	$5-6/KG FOB		Inquiry
Flibanserin 1kg	Pharmaceutical Grade/98	$1/MT FOB	Shaanxi Dideu Medichem Co. Ltd	Inquiry
Flibanserin(167933-07-5)	Pharmaceutical Grade/	$260-328/G FOB	Xi'an Lanshan Biotechnology Co., Ltd.	Inquiry

Flibanserin167933-07-5C20H21F3N4O

Product Description

Seller Information