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Guanfacine 29110-47-2

TDS 3 Inquiries

Unit Price:

$111/KG FOB

Get Latest Price
CAS No.:

29110-47-2

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

zhishang

Packaging:

1kg

Price valid (until):

2028-11-22

Company Type:
Manufactory
Location:
China
Qualification:
Main Products:

Agrochemicals,Daily Chemicals,Catalysts & Chemical Auxiliary Agents,Extract,Inorganic Chemicals,Organic Intermediate

  • Product Description

  • Seller Information

  • Inquiry History

  • Description


      Guanfacine is an adrenergic neuron-blocking agent—classified as a drug affecting the circulatory system—primarily used to treat moderate to severe hypertension. It acts as a central alpha-2 receptor agonist; its antihypertensive potency is one-tenth that of clonidine, requiring a dosage 7 to 10 times higher, while its sedative effect is relatively mild. Following oral administration, it is rapidly and completely absorbed, with a half-life of approximately 21 hours and relatively low plasma concentrations. The initial dosage is 0.5–1 mg taken at bedtime, which may be increased to a maximum of 3 mg daily. Common adverse reactions include dry mouth, drowsiness, and orthostatic hypotension; abrupt discontinuation may lead to withdrawal symptoms such as headache and palpitations. Its use is contraindicated in pregnant and breastfeeding women, and it should be used with caution in patients with cardiovascular disease.

    Guanfacine is an adrenergic neuron-blocking agent—classified as a drug affecting the circulatory system—primarily used to treat moderate to severe hypertension. It acts as a central alpha-2 receptor agonist; its antihypertensive potency is one-tenth that of clonidine, requiring a dosage 7 to 10 times higher, while its sedative effect is relatively mild. Following oral administration, it is rapidly and completely absorbed, with a half-life of approximately 21 hours and relatively low plasma concentrations. The initial dosage is 0.5–1 mg taken at bedtime, which may be increased to a maximum of 3 mg daily. Common adverse reactions include dry mouth, drowsiness, and orthostatic hypotension; abrupt discontinuation may lead to withdrawal symptoms such as headache and palpitations. Its use is contraindicated in pregnant and breastfeeding women, and it should be used with caution in patients with cardiovascular disease.


    Guanfacine is an adrenergic neuron-blocking agent—classified as a drug affecting the circulatory system—primarily used to treat moderate to severe hypertension. It acts as a central alpha-2 receptor agonist; its antihypertensive potency is one-tenth that of clonidine, requiring a dosage 7 to 10 times higher, while its sedative effect is relatively mild. Following oral administration, it is rapidly and completely absorbed, with a half-life of approximately 21 hours and relatively low plasma concentrations. The initial dosage is 0.5–1 mg taken at bedtime, which may be increased to a maximum of 3 mg daily. Common adverse reactions include dry mouth, drowsiness, and orthostatic hypotension; abrupt discontinuation may lead to withdrawal symptoms such as headache and palpitations. Its use is contraindicated in pregnant and breastfeeding women, and it should be used with caution in patients with cardiovascular disease.

    Guanfacine is an adrenergic neuron-blocking agent—classified as a drug affecting the circulatory system—primarily used to treat moderate to severe hypertension. It acts as a central alpha-2 receptor agonist; its antihypertensive potency is one-tenth that of clonidine, requiring a dosage 7 to 10 times higher, while its sedative effect is relatively mild. Following oral administration, it is rapidly and completely absorbed, with a half-life of approximately 21 hours and relatively low plasma concentrations. The initial dosage is 0.5–1 mg taken at bedtime, which may be increased to a maximum of 3 mg daily. Common adverse reactions include dry mouth, drowsiness, and orthostatic hypotension; abrupt discontinuation may lead to withdrawal symptoms such as headache and palpitations. Its use is contraindicated in pregnant and breastfeeding women, and it should be used with caution in patients with cardiovascular disease.Guanfacine is an adrenergic neuron-blocking agent—classified as a drug affecting the circulatory system—primarily used to treat moderate to severe hypertension. It acts as a central alpha-2 receptor agonist; its antihypertensive potency is one-tenth that of clonidine, requiring a dosage 7 to 10 times higher, while its sedative effect is relatively mild. Following oral administration, it is rapidly and completely absorbed, with a half-life of approximately 21 hours and relatively low plasma concentrations. The initial dosage is 0.5–1 mg taken at bedtime, which may be increased to a maximum of 3 mg daily. Common adverse reactions include dry mouth, drowsiness, and orthostatic hypotension; abrupt discontinuation may lead to withdrawal symptoms such as headache and palpitations. Its use is contraindicated in pregnant and breastfeeding women, and it should be used with caution in patients with cardiovascular disease.

    Guanfacine is an adrenergic neuron-blocking agent—classified as a drug affecting the circulatory system—primarily used to treat moderate to severe hypertension. It acts as a central alpha-2 receptor agonist; its antihypertensive potency is one-tenth that of clonidine, requiring a dosage 7 to 10 times higher, while its sedative effect is relatively mild. Following oral administration, it is rapidly and completely absorbed, with a half-life of approximately 21 hours and relatively low plasma concentrations. The initial dosage is 0.5–1 mg taken at bedtime, which may be increased to a maximum of 3 mg daily. Common adverse reactions include dry mouth, drowsiness, and orthostatic hypotension; abrupt discontinuation may lead to withdrawal symptoms such as headache and palpitations. Its use is contraindicated in pregnant and breastfeeding women, and it should be used with caution in patients with cardiovascular disease.

    Guanfacine is an adrenergic neuron-blocking agent—classified as a drug affecting the circulatory system—primarily used to treat moderate to severe hypertension. It acts as a central alpha-2 receptor agonist; its antihypertensive potency is one-tenth that of clonidine, requiring a dosage 7 to 10 times higher, while its sedative effect is relatively mild. Following oral administration, it is rapidly and completely absorbed, with a half-life of approximately 21 hours and relatively low plasma concentrations. The initial dosage is 0.5–1 mg taken at bedtime, which may be increased to a maximum of 3 mg daily. Common adverse reactions include dry mouth, drowsiness, and orthostatic hypotension; abrupt discontinuation may lead to withdrawal symptoms such as headache and palpitations. Its use is contraindicated in pregnant and breastfeeding women, and it should be used with caution in patients with cardiovascular disease.vGuanfacine is an adrenergic neuron-blocking agent—classified as a drug affecting the circulatory system—primarily used to treat moderate to severe hypertension. It acts as a central alpha-2 receptor agonist; its antihypertensive potency is one-tenth that of clonidine, requiring a dosage 7 to 10 times higher, while its sedative effect is relatively mild. Following oral administration, it is rapidly and completely absorbed, with a half-life of approximately 21 hours and relatively low plasma concentrations. The initial dosage is 0.5–1 mg taken at bedtime, which may be increased to a maximum of 3 mg daily. Common adverse reactions include dry mouth, drowsiness, and orthostatic hypotension; abrupt discontinuation may lead to withdrawal symptoms such as headache and palpitations. Its use is contraindicated in pregnant and breastfeeding women, and it should be used with caution in patients with cardiovascular disease.




    Guanfacine is an adrenergic neuron-blocking agent—classified as a drug affecting the circulatory system—primarily used to treat moderate to severe hypertension. It acts as a central alpha-2 receptor agonist; its antihypertensive potency is one-tenth that of clonidine, requiring a dosage 7 to 10 times higher, while its sedative effect is relatively mild. Following oral administration, it is rapidly and completely absorbed, with a half-life of approximately 21 hours and relatively low plasma concentrations. The initial dosage is 0.5–1 mg taken at bedtime, which may be increased to a maximum of 3 mg daily. Common adverse reactions include dry mouth, drowsiness, and orthostatic hypotension; abrupt discontinuation may lead to withdrawal symptoms such as headache and palpitations. Its use is contraindicated in pregnant and breastfeeding women, and it should be used with caution in patients with cardiovascular disease.

    Guanfacine is an adrenergic neuron-blocking agent—classified as a drug affecting the circulatory system—primarily used to treat moderate to severe hypertension. It acts as a central alpha-2 receptor agonist; its antihypertensive potency is one-tenth that of clonidine, requiring a dosage 7 to 10 times higher, while its sedative effect is relatively mild. Following oral administration, it is rapidly and completely absorbed, with a half-life of approximately 21 hours and relatively low plasma concentrations. The initial dosage is 0.5–1 mg taken at bedtime, which may be increased to a maximum of 3 mg daily. Common adverse reactions include dry mouth, drowsiness, and orthostatic hypotension; abrupt discontinuation may lead to withdrawal symptoms such as headache and palpitations. Its use is contraindicated in pregnant and breastfeeding women, and it should be used with caution in patients with cardiovascular disease.

    Guanfacine is an adrenergic neuron-blocking agent—classified as a drug affecting the circulatory system—primarily used to treat moderate to severe hypertension. It acts as a central alpha-2 receptor agonist; its antihypertensive potency is one-tenth that of clonidine, requiring a dosage 7 to 10 times higher, while its sedative effect is relatively mild. Following oral administration, it is rapidly and completely absorbed, with a half-life of approximately 21 hours and relatively low plasma concentrations. The initial dosage is 0.5–1 mg taken at bedtime, which may be increased to a maximum of 3 mg daily. Common adverse reactions include dry mouth, drowsiness, and orthostatic hypotension; abrupt discontinuation may lead to withdrawal symptoms such as headache and palpitations. Its use is contraindicated in pregnant and breastfeeding women, and it should be used with caution in patients with cardiovascular disease.

    Guanfacine is an adrenergic neuron-blocking agent—classified as a drug affecting the circulatory system—primarily used to treat moderate to severe hypertension. It acts as a central alpha-2 receptor agonist; its antihypertensive potency is one-tenth that of clonidine, requiring a dosage 7 to 10 times higher, while its sedative effect is relatively mild. Following oral administration, it is rapidly and completely absorbed, with a half-life of approximately 21 hours and relatively low plasma concentrations. The initial dosage is 0.5–1 mg taken at bedtime, which may be increased to a maximum of 3 mg daily. Common adverse reactions include dry mouth, drowsiness, and orthostatic hypotension; abrupt discontinuation may lead to withdrawal symptoms such as headache and palpitations. Its use is contraindicated in pregnant and breastfeeding women, and it should be used with caution in patients with cardiovascular disease.

    Guanfacine is an adrenergic neuron-blocking agent—classified as a drug affecting the circulatory system—primarily used to treat moderate to severe hypertension. It acts as a central alpha-2 receptor agonist; its antihypertensive potency is one-tenth that of clonidine, requiring a dosage 7 to 10 times higher, while its sedative effect is relatively mild. Following oral administration, it is rapidly and completely absorbed, with a half-life of approximately 21 hours and relatively low plasma concentrations. The initial dosage is 0.5–1 mg taken at bedtime, which may be increased to a maximum of 3 mg daily. Common adverse reactions include dry mouth, drowsiness, and orthostatic hypotension; abrupt discontinuation may lead to withdrawal symptoms such as headache and palpitations. Its use is contraindicated in pregnant and breastfeeding women, and it should be used with caution in patients with cardiovascular disease.

    Guanfacine is an adrenergic neuron-blocking agent—classified as a drug affecting the circulatory system—primarily used to treat moderate to severe hypertension. It acts as a central alpha-2 receptor agonist; its antihypertensive potency is one-tenth that of clonidine, requiring a dosage 7 to 10 times higher, while its sedative effect is relatively mild. Following oral administration, it is rapidly and completely absorbed, with a half-life of approximately 21 hours and relatively low plasma concentrations. The initial dosage is 0.5–1 mg taken at bedtime, which may be increased to a maximum of 3 mg daily. Common adverse reactions include dry mouth, drowsiness, and orthostatic hypotension; abrupt discontinuation may lead to withdrawal symptoms such as headache and palpitations. Its use is contraindicated in pregnant and breastfeeding women, and it should be used with caution in patients with cardiovascular disease.

    Guanfacine is an adrenergic neuron-blocking agent—classified as a drug affecting the circulatory system—primarily used to treat moderate to severe hypertension. It acts as a central alpha-2 receptor agonist; its antihypertensive potency is one-tenth that of clonidine, requiring a dosage 7 to 10 times higher, while its sedative effect is relatively mild. Following oral administration, it is rapidly and completely absorbed, with a half-life of approximately 21 hours and relatively low plasma concentrations. The initial dosage is 0.5–1 mg taken at bedtime, which may be increased to a maximum of 3 mg daily. Common adverse reactions include dry mouth, drowsiness, and orthostatic hypotension; abrupt discontinuation may lead to withdrawal symptoms such as headache and palpitations. Its use is contraindicated in pregnant and breastfeeding women, and it should be used with caution in patients with cardiovascular disease.

    Guanfacine is an adrenergic neuron-blocking agent—classified as a drug affecting the circulatory system—primarily used to treat moderate to severe hypertension. It acts as a central alpha-2 receptor agonist; its antihypertensive potency is one-tenth that of clonidine, requiring a dosage 7 to 10 times higher, while its sedative effect is relatively mild. Following oral administration, it is rapidly and completely absorbed, with a half-life of approximately 21 hours and relatively low plasma concentrations. The initial dosage is 0.5–1 mg taken at bedtime, which may be increased to a maximum of 3 mg daily. Common adverse reactions include dry mouth, drowsiness, and orthostatic hypotension; abrupt discontinuation may lead to withdrawal symptoms such as headache and palpitations. Its use is contraindicated in pregnant and breastfeeding women, and it should be used with caution in patients with cardiovascular disease.

    Items Specifications
    appearance white powder
    purity 99%


    ECHEMI Editorial Reference
    Guanfacine is a selective α2A receptor agonist.Target: α2A ReceptorGuanfacine is a sympatholytic. It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention resulting from interaction with receptors in the former. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α2A norepinephrine autoreceptors, which results in reduced perip
    Solid
    Guanfacine is a member of acetamides.|Guanfacine, or BS 100-141, is a selective alpha-A2 adrenergic receptor agonist initially indicated for the treatment of hypertension but is now indicated as an extended release tablet for the treatment of ADHD. Guanfacine was first described in the literature in 1974. Guanfacine was granted FDA approval on 27 October 1986.|Guanfacine is a Central alpha-2 Adrenergic Agonist. The mechanism of action of guanfacine is as an Adrenergic alpha2-Agonist.|Guanfacine is a selective alpha-adrenergic receptor agonist used for the treatment of hypertension and attention deficit hyperactivity disorder (ADHD) in adults and children. Guanfacine has not been linked to serum enzyme elevations during treatment or to cases of acute, clinically apparent liver injury.|Guanfacine is a centrally acting adrenergic agonist with non-stimulant and antihypertensive property. Guanfacine selectively stimulates alpha-2 adrenergic receptors in the central nervous system, thereby resulting in inhibition of sympathetic nervous system outflow. Used alone or in combination with other drugs, this agent causes reduction of peripheral and renal vascular resistance, and lowers both systolic and diastolic blood pressure and heart rate.|A centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS.

    Certificates
    • Guanfacine 29110-47-2 Certificates 1 TDS

    Basic Info
    Product Name:

    Guanfacine

    Other Name:

    Benzeneacetamide,N-(aminoiminomethyl)-2,6-dichloro-;Acetamide,N-amidino-2-(2,6-dichlorophenyl)-;N-(Aminoiminomethyl)-2,6-dichlorobenzeneacetamide;[(2,6-Dichlorophenyl)acetyl]guanidine;N-Amidino-2-(2,6-dichlorophenyl)acetamide;Guanfacine;Guanfascine;Guarfacine;Guanfacin

    CAS No.:

    29110-47-2

    Molecular Formula:

    C9H9Cl2N3O

    InChIKeys:

    InChIKey=INJOMKTZOLKMBF-UHFFFAOYSA-N

    Molecular Weight:

    246.09326

    Exact Mass:

    246.09

    EC Number:

    249-442-8

    UNII:

    30OMY4G3MK

    DSSTox ID:

    DTXSID9046944

    NCI Thesaurus Code:

    C61779

    ATC Code:

    C02AC02|C - Cardiovascular system

    HScode:

    2925290090

    Characteristics
    PSA:

    81.5

    XLogP3:

    1.7

    Appearance:

    Solid

    Density:

    1.5±0.1 g/cm3

    Melting Point:

    226 °C

    Boiling Point:

    424.9ºC at 760 mmHg

    Flash Point:

    210.8ºC

    Refractive Index:

    1.635

    Water Solubility:

    1.39e-01 g/L

    Storage Conditions:

    Refrigerator

    Vapor Pressure:

    2E-07mmHg at 25°C

    Collision Cross Section:

    148.9 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

    Hazard Identification

    Classification of the substance or mixture

    Acute toxicity - Category 3, Oral

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H301 Toxic if swallowed

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    Response

    P301+P316 IF SWALLOWED: Get emergency medical help immediately.

    P321 Specific treatment (see ... on this label).

    P330 Rinse mouth.

    Storage

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Manufactory

    Main Products:

    Agrochemicals,Daily Chemicals,Catalysts & Chemical Auxiliary Agents,Extract,Inorganic Chemicals,Organic Intermediate

    Location:

    hisense intelligence valley,no 2116,of phoenix road

    Payment Terms:

    TT against copy of documents,D/P,L/C

    Average lead Time:

    7

    Total Annual Revenue:

    Less than $1 million

    Total Employees:

    11-50

    Year of Establishment:

    2017

     SHANDONG LOOK CHEMICAL CO.LTD, a new chemical enterprise in researching, manufacturing and supplying of chemicals located in beautiful “Spring City”-Jinan.Our company mainly working on the researching new-born APIs, intermediate ( especially Carbohydrate derivatives series). Meanwhile, we made huge breakthrough in industries of food, feed additives, cosmetics ,dye and industrial chemicals. Our company enjoyed great reputation both domestic and abroad under the belief of “Integrity management,Quality controlling and Customer orientation”.  Web : www.chinalookchemical.com 

        We had been cooperated with NingXia University and Shandong University on more than ten projects for years and which had been in mass production on the market. We now have more than 80 people in our team and built research center in Jinan and Ningxia. Our manufacturing site allocated in chemical industry parks of Zhangqiu, Heze, Dezhou and Ningxia Fine Chemical Park. We strictly complying with ISO9001 and ISO 2000 standard in manufacturing process, our lab and workshop tightly in accordance with GMP standard.Our products best selling in Europe, South and North America,Asia pacific area and Africa. We sincerely welcome new and regular customers around the world visit us for business negotiation.

  • Inquiry History
    3 Inquiries
    Country Product Purchase Quantity Date Posted
    Greece

    Guanfacine

    300 MG May 1, 2026
    Russia

    Guanfacine

    1 KG Sep 8, 2026
    United States

    Guanfacine

    1 G Jun 13, 2024
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