ANTI-HAIR-LOSS RU-58841/Non-steroidal antiandrogen/Androgen receptor antagonist/APIS

Description

RU-58841 (also known as PSK-3841) is a synthetic non-steroidal anti-androgen compound with CAS number 154992-24-2, molecular formula C₁₇H₁₈F₃N₃O₃ and molecular weight 369.34. It can specifically bind to androgen receptors and block the transduction of androgen signals. Designed primarily for topical administration, it is a classic tool compound in the field of androgen-related research. This product is high-purity powder (≥98%, determined by HPLC), featuring stable properties for easy storage and experimental preparation, and can be directly used in various scientific research experiments. This product is for research use only and is not intended for human use or clinical treatment.

Key Effects

The core mechanism of action of RU-58841 is acting as an androgen receptor antagonist. It competitively binds to androgen receptors, thereby blocking the signaling effects of androgens such as testosterone and dihydrotestosterone (DHT) on target tissues. Unlike traditional steroidal antiandrogens, it has a non-steroidal structure and features local action. For this reason, it is widely used in research fields including androgenetic alopecia and cutaneous androgen responses, serving as an important tool compound for studying androgen signaling pathways.

Specifically, its functions demonstrated in scientific research experiments include:
Androgen receptor antagonism: It specifically binds to androgen receptors and blocks signal transduction of androgens such as DHT and testosterone.
Non-steroidal structural feature: Distinct from steroidal antiandrogens, it possesses a novel structure and holds unique value in receptor selectivity research.
Local action design: It is mainly applied in local administration research, providing an experimental tool for local anti-androgen intervention.
Research value in alopecia models: Research effects on hair regrowth have been observed in animal models related to androgenetic alopecia.

Applications

RU-58841 is currently mainly used in scientific research related to androgens, covering multiple research stages ranging from receptor molecular assays to animal models. It is a common tool compound in fields such as androgenetic alopecia and acne, and is also applied in the screening and development of novel non-steroidal anti-androgen drugs.

Specific research application scenarios include:
Androgenetic alopecia research: Used in animal experimental studies on hair loss mechanisms and local interventions.
Cutaneous androgen research: Used to explore the mechanisms underlying skin tissue responses to androgens.
Acne-related research: Used in experimental studies of androgen-associated sebaceous gland activity.
Drug screening and development: As a representative molecule of non-steroidal anti-androgens, it is used for activity comparison and lead screening of new compounds.
Receptor binding assays: Used for in vitro molecular-level experiments such as the evaluation of androgen receptor binding activity.