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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > LOXO-101 for Sale > Larotrectinib CAS 1223403-58-4 Selective TRK Inhibitor for NTRK Fusion-Positive Cancer Research kr
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Larotrectinib CAS 1223403-58-4 Selective TRK Inhibitor for NTRK Fusion-Positive Cancer Research kr

TDS

Unit Price: Get Latest Price
CAS No.:

1223403-58-4

Grade:

Reagent Grade

Content:

99%

Port:

qingdao

Brand:

//

Packaging:

5g, 25g, 100g, 500g

Sample Available:

Yes

Price valid (until):

2026-10-11

Company Type:
Trader
Location:
China
Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance
Average Lead Time:
7 days
Qualification:
Main Products:

Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

  • Product Details

  • Seller Information

  • Description

    —— Product Specification ——

    Parameter Specification Details
    Product Name Larotrectinib LOXO-101; ARRY-470
    CAS Number 1223403-58-4 1223403-58-4
    Molecular Formula C₂₁H₂₂F₂N₆O₂ 21 carbons, 22 hydrogens, 2 fluorine, 6 nitrogens, 2 oxygens 
    Molecular Weight 428.44 g/mol — 
    Appearance Yellow solid Visual inspection 
    Purity ≥98.0% Determined by HPLC 
    TRK IC₅₀ 2 – 20 nM Potent inhibition of TRKA, TRKB, and TRKC 
    Density 1.55 ± 0.1 g/cm³ (Predicted) — 
    pKa 8.41 ± 0.40 (Predicted) — 
    Solubility DMSO: ~5 mg/mL Soluble in DMSO 
    Storage -20°C Sealed containers, protect from light and moisture 
    Packaging 5mg, 10mg, 25mg, 50mg, 100mg, 500mg Amber glass vials
    Application Research use only Oncology research, TRK inhibition studies


    —— Product Detail ——

    Product Overview

    • Larotrectinib (CAS 1223403-58-4), also known as LOXO-101 or ARRY-470, is a potent, orally bioavailable, ATP-competitive inhibitor of the tropomyosin receptor kinase (TRK) family, which includes TRKA, TRKB, and TRKC . It appears as a yellow solid with the molecular formula C₂₁H₂₂F₂N₆O₂ and a molecular weight of 428.44 g/mol


    Packaging & Shipping

                  • Research quantities: 5mg, 10mg, 25mg amber glass vials

                  • Bulk quantities: 50mg, 100mg amber glass bottles

                  • Custom packaging available upon request

                  • Not classified as hazardous material for transport under normal conditions

                  • Product for research and analytical use only; not for human therapeutic use

    Shop CAS 18048-64-1 Eltrombopag Intermediate for Pharmaceutical Research  kr-Detailed Image 1

    — Company profile ——


     Shop CAS 1231930-42-9 Abemaciclib Intermediate for Pharma researech use KR-Detailed Image 1

    Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

    Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

    We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

    To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

    Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

     

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    —— Q&A ——

    Q1: How to confirm the product quality before placing orders?
    A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

    Q2: Can you supply free samples?
    A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

    Q3: How do you treat quality complaints?
    A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

    Q4: What is your MOQ? Is there a discount?
    A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
    Q: Is there a discount?
    A: Yes, for larger quantities, we always support with better prices.

    Q5: How to start orders or make payments?
    A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.



    ECHEMI Editorial Reference
    Larotrectinib (VITRAKVIR) is an orally administered, small molecule, highly-selective, tropomyosin receptor kinase (TRK) inhibitor that was developed by Loxo Oncology in collaboration with Bayer AG as a treatment for adult and paediatric patients whose cancers harbour neurotrophic receptor tyrosine kinase (NTRK) gene fusions.Larotrectinib is a highly selective, potent inhibitor of TRKA, TRKB and TRKC (in vitro 50% inhibitory constant 5–11 nmol/L), with minimal or no activity against other kinase and non-kinase targets [1, 2]. Inhibition of TRKs prevents TRK activation, resulting in both the induction of cellular apoptosis and the inhibition of cell growth in tumours that overexpress TRKs.
    LOXO-101 is an inhibitor of the tropomyosin-related kinases TrkA, TrkB, and TrkC (IC50s = 2-20 nM). It is selective for TrkA, -B, and -C over a panel of 226 kinases at 1 μM. LOXO-101 inhibits the growth of CUTO-3.29, KM12, and MO-91 patient-derived cancer cell lines (IC50s = <100, <10, and <10 nM, respectively).In vivo, LOXO-101 (60 and 200 mg/kg) reduces tumor growth in a KM12 mouse xenograft model.
    Larotrectinib, also known as LOXO-101 and ARRY-470, is a small molecule that was designed to block the ATP-binding site of the TRKA, TRKB, and TRKC, serving as a highly specific and potent inhibitor of all of the three tropomyosin kinase receptors.
    Class: receptor tyrosine kinase; Treatment: NTRK-altered solid tumors; Other name: ARRY-407, LOXO-101; Oral bioavailability = 25%; Elimination half-life = 2.9 h; Protein binding = 70%

    Certificates
    • Larotrectinib CAS 1223403-58-4 Selective TRK Inhibitor for NTRK Fusion-Positive Cancer Research kr Certificates 1 TDS

    Basic Info
    Product Name:

    LOXO-101

    Other Name:

    LOXO-101;CS-2322;LOXO101;LOXO 101;LOXO-101 Larotrectinib;LOXO-101 (ARRY-470,Larotrectinib);LOXO-101,LAROTRECTINIB,ARRY-470;ARRY 470;(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide

    CAS No.:

    1223403-58-4

    Molecular Formula:

    C21H22F2N6O2

    InChIKeys:

    InChIKey=NYNZQNWKBKUAII-KBXCAEBGSA-N

    Molecular Weight:

    428.44

    Exact Mass:

    428.44

    Color/Form:

    Yellow

    Characteristics
    PSA:

    86

    XLogP3:

    3.0234

    Appearance:

    White to yellow solid

    Density:

    1.55±0.1 g/cm3(Predicted)

    PKA:

    8.41±0.40(Predicted)

    Critical Temperature & Pressure:

    RT

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

    Location:

    RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA

    Payment Terms:

    TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7 days

    Total Annual Revenue:

    $1 million-$2.5 million

    Total Employees:

    11-50

    Year of Establishment:

    2022

    Jinan Topfull Chemical Co., Ltd. is a global chemical Industrial and focuses on advanced chemical technology. Specialized in Cosmetic materials, water treatment, fine chemicals and so on. We are looking forward to working together with the people of all circles at home and abroad to seek common development!
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