Cibinetide, ARA-290, ARA290, PH-BSP/neuroprotection research, anti-inflammatory research

Description

ARA-290 (International Nonproprietary Name: Cibinetide, also known as pHBSP) is a synthetic 11-amino-acid polypeptide with CAS number 1208243-50-8, molecular formula C₅₁H₈₄N₁₆O₂₁ and molecular weight 1257.3. It is modified from the helix B domain of the erythropoietin (EPO) molecule. While retaining the tissue-protective properties, it loses the erythropoiesis-stimulating activity, making it a representative peptide tool compound in the research of tissue repair and anti-inflammation. This product is supplied as high-purity lyophilized powder (≥98%, determined by HPLC), featuring stable properties for easy storage and experimental preparation.

Key Effects

The most core feature of ARA-290 lies in its mechanism of action of "selective activation". It can specifically bind to the innate repair receptor (IRR), a heterodimer composed of the EPO receptor and the β-common receptor CD131. This receptor is normally transiently expressed in damaged tissues and participates in initiating tissue repair and protective processes. Meanwhile, ARA-290 does not act on the classical EPO receptor responsible for erythropoiesis, so it does not cause changes in red blood cell count. This design endows it with unique research value in tissue protection studies.

Specifically, its effects demonstrated in scientific research experiments include:
Selective receptor activation: It specifically activates the innate repair receptor (IRR) to initiate signal pathways related to tissue protection without stimulating erythropoiesis.
Tissue protection and repair: It has been observed to possess research potential for tissue protection and repair promotion in multiple animal models.
Inflammatory regulatory effect: Research data indicates that it is associated with the regulation of various inflammatory factors, serving as a commonly used tool molecule for anti-inflammatory mechanism research.
Research value in neuroprotection: Relevant manifestations of neuroprotection and nerve fiber repair have been observed in research models related to neuropathy.
Clear mechanism of action: It has a well-defined target and short structure, facilitating molecular-level mechanistic research such as receptor binding and signal pathway investigation.

Applications

ARA-290 is currently mainly applied in scientific research related to tissue protection, neuroscience and inflammation, covering various experimental scenarios ranging from molecular mechanisms to animal models. It serves as a representative tool compound in the research of EPO-derived polypeptides and also provides an important reference molecule for the research and development of a new generation of tissue-protective polypeptide drugs.

Specific research application scenarios include:
Tissue protection and repair research: Used to study protective mechanisms and repair pathways in models of tissue injury, ischemia-reperfusion, etc.
Neuropathy research: Suitable for animal model and mechanism research in fields such as diabetic neuropathy and neuropathic pain.
Inflammatory mechanism research: Applied in inflammation-related experiments including inflammatory factor regulation and immune cell polarization.
Metabolic disease research: Used as a tool compound in studies on metabolic control and complications associated with type 2 diabetes.
Drug research and development reference: As a representative molecule of non-erythropoietic EPO-derived peptides, it is utilized for polypeptide structure optimization and lead compound research.
In vitro cellular and molecular experiments: Can be used for molecular-level experiments such as evaluation of receptor binding activity and study of downstream signaling pathways.