99% Purity PP405 (JXL069) CAS 2260696-63-5 Ru58841, Ky19382, Way316606, Erdafitinib Wholesale Price
39 Inquiries
2260696-63-5
Industrial Grade
99%
Qingdao
Guozhao
25kg/Drum
Yes
2026-10-16
CHEMICALS
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Product Details
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Seller Information
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Inquiry History
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DescriptionBasic Info
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Product Name:
2-Propenoic acid, 3-[1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-cyano-, (2E)-
Other Name:2-Propenoic acid, 3-[1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]-2-cyano-, (2E)-;JXL-069;PP405,JXL-069;JXL-069,pp405;PP405
CAS No.:2260696-63-5
Molecular Formula:C20H11F6N3O2
Molecular Weight:439.31
Categories:
Characteristics-
Density:
1.44±0.1 g/cm3(Predicted)
Boiling Point:521.3±50.0 °C(Predicted)
PKA:0.65±0.19(Predicted)
Research-
Class:
Pan-FGFR tyrosine kinase inhibitor (FGFR1-4); antineoplastic (ATC L01EN01)
Status:Approved (FDA accelerated approval 2019-04-12; converted to regular approval 2024-01-19; EMA approval 2024-08)
Mechanism:Erdafitinib is an orally bioavailable, functionally selective small-molecule inhibitor of fibroblast growth factor receptors 1-4 (FGFR1-4). It inhibits FGFR tyrosine kinase activity (IC50 1.2-5.7 nM), blocking downstream RAS-MAPK/ERK and PI3K-AKT signaling that drives proliferation and survival of tumor cells harboring activating FGFR alterations (mutations, amplifications, or fusions). Rapid lysosomal uptake contributes to prolonged inhibition of FGFR signaling.
EC50 (Fgfr1 Ic50):1.2 nM
EC50 (Fgfr3 Ic50):3.0 nM
EC50 (Fgfr2 Ic50):2.5 nM
EC50 (Fgfr4 Ic50):5.7 nM
EC50 (Vegfr2 Ic50):36.8 nM (approximately 30-fold selectivity vs FGFR1)
Source:Perera TPS, et al. Mol Cancer Ther. 2017;16(6):1010-1020.DOI
Clinical Development:FDA:Balversa (approved 2019-04-12)
References-
ChEMBL:DrugBank:KEGG DRUG:PubChem:Literature:
FDA: Approval announcement 2024-01-19; FDA: BALVERSA label (NDA 212018, BLC2001); NEJM: Loriot et al. (2023) — THOR Cohort 1; NEJM: Loriot et al. (2019) — BLC2001; Mol Cancer Ther: Perera et al. (2017) — discovery pharmacology
Disclaimer:Erdafitinib (Balversa) is a prescription medicine approved by the US FDA and the EMA for specific oncology indications. ECHEMI lists this product for industrial sourcing and supply-chain reference only. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or a substitute for approved therapy. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
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Seller Information
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Business Type:
Distributor
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Main Products:
CHEMICALS
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Location:
No. 109, Chailu Street, Qingnian Park Subdistrict, Huaian District, Jinan City, Shandong Province 280
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Year of Establishment:
2026
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Inquiry History39 Inquiries
Country Product Purchase Quantity Date Posted
Lithuania
2260696-63-5
1 KG Oct 13, 2025
United States
JXL-082 2260696-63-5
5 G Nov 1, 2025
United States
JXL-082 2260696-63-5 for Anti Hair Loss JXL082
5 Jan 26, 2026
United States
JXL-069 2260696-63-5 for Anti Hair Loss JXL 069
1 G Aug 9, 2025
United States
PP405/JXL-069
1 G Feb 19, 2026
United Kingdom
Jxl069
1 MG Oct 17, 2026
United Kingdom
Jxl069 - pp405
10 MT Oct 12, 2026
United States
JXL-069
3 MT May 7, 2026
Brazil
PP405
20 Mar 5, 2026
Canada
JXL-069
10 MG Feb 24, 2026
United States
JXL-069
100 G Feb 7, 2026
Australia
JXL-069
1 G Jan 14, 2026
Australia
PP405
10 G Dec 11, 2025
United States
JXL-069
10 MT Nov 7, 2025
United Kingdom
JXL-069
1 MT Sep 8, 2025
Australia
JXL069
1 KG Aug 26, 2025
Germany
jxl-069
1 G Aug 22, 2025
United States
Jxl-069
1 G Aug 5, 2025
United States
Jxl-069
100 G Aug 7, 2026
United States
PP405
5 G Mar 26, 2026 Post an enquiry for this product
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