Product Overview

4-Bromo-2-methylaniline is an organic compound with the molecular formula C₇H₈BrN and molecular weight of 186.05 g/mol. This white to off-white crystalline solid is a valuable intermediate in pharmaceutical, agrochemical, and dye research. The compound features a bromine atom at the 4-position, a methyl group at the 2-position, and an amino group on the aromatic ring.

Synthetic Process

• Bromination: 2-Methylaniline is brominated at the 4-position using elemental bromine or NBS under controlled conditions

• Reduction: Alternatively, 4-bromo-2-methylnitrobenzene is reduced to the corresponding aniline

• Purification: The crude product is purified by recrystallization from suitable solvents

• Drying: The purified product is dried under vacuum

Mechanism of Action

• Cross-Coupling Substrate: The aryl bromide enables Suzuki-Miyaura and other coupling reactions

• Amine Functionalization: The amino group can be acylated, alkylated, or converted to diazonium salts

• Dye Synthesis: Aromatic amines are key intermediates for azo dyes

Research Applications & Market Significance

• Pharmaceutical Research: Building block for drug discovery programs

• Dye Synthesis: Intermediate for azo dyes and other colorants

• Agrochemical Synthesis: Intermediate for herbicide and pesticide production

• Organic Synthesis: Versatile intermediate for functionalized aniline derivatives

Quality Specifications

• Purity: ≥98.0% determined by GC

• Melting point: 52-55°C

• Loss on drying: ≤0.5%

• Storage: 2-8°C, sealed, protected from light

• Stable for 24 months when properly stored

Packaging & Shipping

• Research quantities: 25g, 100g amber glass bottles

• Bulk quantities: 500g, 1kg amber glass bottles

• Shipped at ambient temperature