Product Overview

4-Bromo-2-methylbenzaldehyde is an organic compound with the molecular formula C₈H₇BrO and molecular weight of 199.05 g/mol. This white to off-white crystalline solid is a valuable intermediate in pharmaceutical and agrochemical research. The compound features a bromine atom, a methyl group, and an aldehyde group on the aromatic ring.

Synthetic Process

• Formylation: 3-Bromotoluene is formylated using the Vilsmeier-Haack reaction or other formylation methods

• Oxidation: Alternatively, 4-bromo-2-methylbenzyl alcohol is oxidized to the aldehyde

• Purification: The crude product is purified by recrystallization or distillation

• Drying: The purified product is dried under vacuum

Mechanism of Action

• Aldehyde Reactivity: The aldehyde group participates in condensation, reduction, and oxidation reactions

• Cross-Coupling Substrate: The aryl bromide enables Suzuki-Miyaura and other coupling reactions

• Electrophilic Aromatic Substitution: The methyl group directs electrophilic substitution to specific positions

Research Applications & Market Significance

• Pharmaceutical Research: Building block for drug discovery programs

• Agrochemical Synthesis: Intermediate for herbicides and fungicides

• Organic Synthesis: Versatile intermediate for functionalized aromatic compounds

• Material Science: Used in the preparation of specialty polymers and functional materials

Quality Specifications

• Purity: ≥98.0% determined by GC

• Melting point: 42-45°C

• Loss on drying: ≤0.5%

• Storage: 2-8°C, sealed, protected from light

• Stable for 24 months when properly stored

Packaging & Shipping

• Research quantities: 25g, 100g amber glass bottles

• Bulk quantities: 500g, 1kg amber glass bottles

• Shipped at ambient temperature