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Fluralaner864731-61-3

Name: Fluralaner864731-61-3
Brand: OORENT
SKU: pr2610121625
Price: 33 USD
Availability: InStock

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Unit Price:

$33-34/MT FOB

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CAS No.:

864731-61-3

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

shanghai

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Sample Available:

Yes

Price valid (until):

2026-11-12

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Payment Terms:

100% TT in advance

Average Lead Time:

10 days

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Detailv

Fluralaner Basic information

Product Name:	Fluralaner
Synonyms:	Fluralaner;A1443; AH252723;AH252723;Fluralaner-012;Fluralaner (A1443;Frellana;Fluralaner D2Q: What is Fluralaner D2 Q: What is the CAS Number of Fluralaner D2;Fluralaner D3Q: What is Fluralaner D3 Q: What is the CAS Number of Fluralaner D3
CAS:	864731-61-3
MF:	C22H17Cl2F6N3O3
MW:	556.29
EINECS:	200-001-8
Product Categories:	1;API;864731-61-3
Mol File:	864731-61-3.mol

Fluralaner Chemical Properties

density	1.51±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:150.0(Max Conc. mg/mL);269.65(Max Conc. mM) Ethanol:25.0(Max Conc. mg/mL);44.94(Max Conc. mM)
pka	12.50±0.46(Predicted)
form	A crystalline solid
color	White to off-white
InChIKey	MLBZKOGAMRTSKP-UHFFFAOYSA-N
SMILES	C(NCC(=O)NCC(F)(F)F)(=O)C1=CC=C(C2CC(C3=CC(Cl)=CC(Cl)=C3)(C(F)(F)F)ON=2)C=C1C

Safety Information

MSDS Information

Fluralaner Usage And Synthesis

Description	Fluralaner (INN) is a systemic insecticide and acaricide that is administered orally. The U.S. Food and Drug Administration (FDA) approved it under the trade name Bravecto for flea treatment in dogs in May 2014. The EU approved the drug in February 2014. Australia approved it for the treatment and prevention of ticks and fleas on dogs in January 2015.
Uses	Fluralaner(864731-61-3) is a novel systemically administered insecticidal and acaricidal compound that provides long-acting efficacy after oral administration to dogs. Fluralaner belongs to a new class of compounds, the isoxazolines. A field study has shown that a single fluralaner dose administered orally to dogs provides at least twelve weeks of flea- and tick-control. The long duration of activity offers a more convenient treatment over monthly flea and tick control treatments with a potential compliance advantage, reducing the risk of vector-transmitted diseases.
Indications	Fluralaner is an insecticide and acaricide used to treat Sarcoptes scabiei var. canis infestation in dogs. Flea treatment. A possible anti-malarial found to kill disease-spreading mosquitoes when they bite treated people.
Pharmacokinetics	Following oral administration, fluralaner is readily absorbed reaching maximum plasma concentrations within 1 day. Food enhances the absorption. Fluralaner is systemically distributed and reaches the highest concentrations in fat, followed by liver, kidney and muscle. The prolonged persistence and slow elimination from plasma (t1/2 = 12 days) and the lack of extensive metabolism provide effective concentrations of fluralaner for the duration of the inter-dosing interval. Individual variation in Cmax and t1/2 was observed. The major route of elimination is the excretion of unchanged fluralaner in faeces (~90% of the dose). Renal clearance is the minor route of elimination.
Side effects	Most pets have very few side effects from fluralaner, provided it is given according to label recommendations and at the prescribed interval (or for off-label use, according to your veterinarian's directions). Side effects may include vomiting, diarrhea, decreased appetite, or flaky skin. vcahospitals.com
Synthesis	The synthesis of fluralaner is mainly obtained by the reaction of the intermediates 4-(5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoazol-3-yl)-2-methylbenzoic acid (Intermediate I) and 2-amino-N-(2,2,2-trifluoroethyl)acetamide (Intermediate II).
Overdosage	No adverse reactions were observed following oral administration to puppies aged 8–9 weeks and weighing 2.0–3.6 kg treated with overdoses of up to 5 times the maximum recommended dose (56 mg, 168 mg and 280 mg fluralaner/kg bodyweight) on three occasions at shorter intervals than recommended (8-week intervals). There were no findings on reproductive performance and no findings of concern on offspring viability when fluralaner was administered orally to Beagle dogs at overdoses of up to 3 times the maximum recommended dose (up to 168 mg/kg bodyweight of fluralaner). The veterinary medicinal product was well tolerated in Collies with a deficient multidrug-resistanceprotein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose (168 mg/kg bodyweight). No treatment-related clinical signs were observed.
Drug interactions	Fluralaner is highly bound to plasma proteins and might compete with other highly bound drugs such as non-steroidal anti-inflammatory drugs (NSAIDs) and the cumarin derivative warfarin. Incubation of fluralaner in the presence of carprofen or warfarin in dog plasma at maximum expected plasma concentrations did not reduce the protein binding of fluralaner, carprofen or warfarin. During clinical field testing, no interactions between Bravecto chewable tablets for dogs and routinely used veterinary medicinal products were observed.
Mode of action	Fluralaner is an inhibitor of the arthropod nervous system. It inhibits γ-aminobutyric acid (GABA)-gated chloride channels (GABAA receptors) and L-glutamate-gated chloride channels (GluCls). Potency of fluralaner is comparable to fipronil (a related GABA-antagonist insecticide and acaricide).

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ECHEMI Editorial Reference

Fluralaner (INN) is a systemic insecticide and acaricide that is administered orally. The U.S. Food and Drug Administration (FDA) approved it under the trade name Bravecto for flea treatment in dogs in May 2014. The EU approved the drug in February 2014. Australia approved it for the treatment and prevention of ticks and fleas on dogs in January 2015.

Basic Info

Product Name:

Fluralaner

Other Name:

Fluralaner;A1443; AH252723;AH252723;Fluralaner-012;Fluralaner (A1443;Frellana;Fluralaner D2Q: What is Fluralaner D2 Q: What is the CAS Number of Fluralaner D2;Fluralaner D3Q: What is Fluralaner D3 Q: What is the CAS Number of Fluralaner D3

CAS No.:

864731-61-3

Molecular Formula:

C22H17Cl2F6N3O3

InChIKeys:

MLBZKOGAMRTSKP-UHFFFAOYSA-N

Molecular Weight:

556.29

Exact Mass:

556.29

EC Number:

200-001-8

DSSTox ID:

DTXSID90235581

Color/Form:

White to off-white

ATC Code:

QP53BE02|QP54AB52

Categories:

Bulk Drug Intermediates

Characteristics

Density:

1.51±0.1 g/cm3(Predicted)

PKA:

12.50±0.46(Predicted)

Critical Temperature & Pressure:

Store at -20°C

See More Fluralaner Properties 

Hazard Identification

Classification of the substance or mixture

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H410 Very toxic to aquatic life with long lasting effects
Prevention	P273 Avoid release to the environment.
Response	P391 Collect spillage.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Fluralaner Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

35 Inquiries

Country	Product	Purchase Quantity	Date Posted
Russia	Fluralaner 98% Powder 864731-61-3 Senwayer	100 KG	Apr 13, 2026
South Africa	Fluralaner 98% Powder 864731-61-3 Senwayer	2 KG	Nov 1, 2023
Mexico	Low Price Wholesale 99% Veterinary API Fluralaner CAS 864731-61-3 white powder HHD HHD	5 KG	Oct 16, 2023
Paraguay	Fluralaner	600 KG	Oct 12, 2026
Paraguay	FLURALANER	30 KG	Oct 13, 2025
Turkey	fluralaner	1 MG	Jun 18, 2025
Vietnam	fluralaner	50 KG	Dec 11, 2024
Ecuador	FLURALANER	10 KG	Nov 19, 2024
India	fluralaner	2 G	Oct 23, 2024
India	Fluralaner	1 G	Oct 18, 2024
Germany	Fluralaner	50 G	May 11, 2024
Brazil	Fluralaner	1 KG	Oct 2, 2026
Paraguay	fluralaner	200 KG	Sep 28, 2026
Denmark	Fluralaner	100 KG	Sep 3, 2026
United States	Fluralaner	25 MG	May 26, 2026
Paraguay	FLURALANER	100 KG	Apr 24, 2026
Turkey	fluralaner	13 G	Jun 30, 2025
Thailand	Fluralaner	1 KG	Apr 6, 2025
India	Fluralaner	2 G	Jan 2, 2025
Ecuador	FLURALANER	25 KG	Nov 21, 2024

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Fluralaner864731-61-3

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