Melatonine CAS:73-31-4 C13H16N2O2

Focusing on innovative research, development, and production in the field of fine chemicals, we prioritize technology, quality, and market orientation. We collaborate with global partners to build a high-tech chemical industry chain and promote sustainable development in the industry.

The company's main products include pharmaceutical intermediates, food additives, essence, spices and plant extracts. The products have passed international certification and are exported to Europe, America, Japan, South Korea and Southeast Asia.

Melatonine Basic information

description Chemical properties Mechanism of action Uses Biological Activity Physiological functions Synthesis of Melatonin

Product Name:	Melatonine
Synonyms:	Melatonin (AS);Melatonine,N-(2-(5-Methoxyindol-3-yl)ethyl)acetaMide;MELATONINE FOR SYNTHESIS 1 G;MELATONINE FOR SYNTHESIS 5 G;Melatonin solution ;N-[2-(5-METHOXY-1H-INDOL-3-YL)ETHYL]ACETAMIDE;N-(2-(5-methoxyindol-3-yl)ethyl)acetamide;MLT
CAS:	73-31-4
MF:	C13H16N2O2
MW:	232.28
EINECS:	200-797-7
Product Categories:	Inhibitors;bulk drug material;Heterocyclic Series;Heterocycles series;Indoles;Melatonin receptor;Tryptamines;Nutritional Supplements;Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Heterocycles;Melatonins;Vitamin series;Alkaloid;Bioactive Small Molecules;Building Blocks;C13 to C27;Cell Biology;Cell Signaling and Neuroscience;Chemical Synthesis;Heterocyclic Building Blocks;M;Neurobiology;Neuroscience;Nutrition Research;Pharmacologicals;Phytochemicals by Chemical Classification;Herb extract;Other APIs;Melatonex;inhibitor;Cosmetics;cosmetics materials;73-31-4
Mol File:	73-31-4.mol

Melatonine Chemical Properties

Melting point	116.5-118 °C (lit.)
Boiling point	374.44°C (rough estimate)
density	1.1099 (rough estimate)
refractive index	1.6450 (estimate)
Fp	9℃
storage temp.	-20°C
solubility	Soluble in ethanol to at least 50mg/ml
pka	16.26±0.46(Predicted)
form	Powder
color	white to off-white
biological source	synthetic (organic)
Merck	14,5816
Specific Activity	53-71nmol/min·mg
BRN	205542
InChIKey	DRLFMBDRBRZALE-UHFFFAOYSA-N
LogP	1.043 (est)
CAS DataBase Reference	73-31-4(CAS DataBase Reference)
NIST Chemistry Reference	Melatonin(73-31-4)

Safety Information

Hazard Codes	T,F
Risk Statements	60-39/23/24/25-23/24/25-11
Safety Statements	24/25-99-53-45-36/37-16-7
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	2
RTECS	AC5955000
F	8-10-23
HS Code	29379000
Hazardous Substances Data	73-31-4(Hazardous Substances Data)
Toxicity	LD50 orally in Rabbit: > 3200 mg/kg

MSDS Information

Melatonine Usage And Synthesis

description	Melatonin is a hormone secreted by the pineal gland, and its chemical structure was 5-methoxy-N-acetyl tryptamine, the physiological function of inhibiting gonad, thyroid, adrenal gland, parathyroid gland and pituitary function, inhibit precocious puberty, reduce pituitary Melanotropin secretion; and has a central nervous system function, can improve the convulsion the threshold, cause drowsiness. When pinealectomy after the animal experiment showed hyperplasia of the glands, weight increase, especially sex and sexual organs of immature rats early, pituitary secretion of LH and FSH increased, increasing secretion of thyroid and adrenal cortex hormone melatonin. More reduced pituitary MSH and whiten the skin of this role. Effects on the central nervous system, in the human EEG showed slow rhythm, increased seizure threshold, sleepiness, but does not affect their behavior and personality, of temporal lobe epilepsy and Ba Jinsen disease can reduce the motor nerve Abnormal EEG changes.
Chemical properties	Melatonin is a slightly off-white, odourless crystalline powder. It is very slightly soluble in water and in dilute hydrochloric acid. Melatonin is a small molecule, a derivative of the amino acid tryptophan, N-acetyl-5 methoxytryptamine. It is a potent hormone with well-recognized activities and the potential to influence many bodily functions. It is produced by the pineal gland in the brain and is secreted when the body recognizes darkness. Melatonin has intense effects on the timing of the sleep/awake cycle, regulating the circadian rhythms of several biological functions. This is its most studied biological activity. Melatonin, as a multifunctional hormone, appears to regulate or modulate other functions in humans through the activation of its receptors and works as a strong antioxidant that protects the DNA. Melatonin’s antioxidant activity may reduce Parkinson’s disease development, prevent cardiac arrhythmia, and, in animals, promote longevity.
Mechanism of action	Melatonin is a naturally occurring hormone produced by the pineal gland and is structurally related to serotonin. Physiologically, melatonin secretion increases soon after the onset of darkness, peaks at 2-4 am and diminishes during the second half of the night. Melatonin is associated with the control of circadian rhythms and entrainment to the light-dark cycle. It is also associated with a hypnotic effect and increased propensity for sleep. The activity of melatonin at the MT1 MT2 receptors is believed to contribute to its sleep-promoting properties via their distinct actions on the circadian clock. The MT1 receptors are thought to inhibit neuronal firing, while the MT2 receptors have been implicated in the phase-shifting response.
Uses	1. Melatonin can be used as medicine health care products, so as to enhance people’s immune function, preventing aging and back to youth. What’s more, it is also a kind of natural “sleeping pill”. 2. Melatonin is a kind of hormone secreted by pineal body of pituitary gland in the body. The amount of melatonin has something to do with light. The weaker the light is, the more the melatonin is, whereas the less. In addition, it is helpful to one’s sleep. 3. Biochemical research.

First aid measures

General advice Consult a physician. Show this material safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Firefighting measures

Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides Nitrogen oxides (NOx) Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.



——  Q&A  ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.