Product Overview

1-Bromo-2-methylbenzene (o-bromotoluene) is an organic compound with the molecular formula C₇H₇Br and molecular weight of 171.03 g/mol. This colorless to light yellow liquid is a valuable intermediate in pharmaceutical, agrochemical, and organic synthesis research. The compound features a bromine atom at the 1-position and a methyl group at the 2-position of the benzene ring.

Synthetic Process

• Bromination: Toluene is brominated using elemental bromine or NBS in the presence of a catalyst

• Purification: The crude product is purified by fractional distillation

• Quality Control: The final product is analyzed to ensure ≥98.0% purity by GC

Mechanism of Action

• Cross-Coupling Substrate: The aryl bromide enables Suzuki-Miyaura and other coupling reactions

• Electrophilic Aromatic Substitution: The methyl group directs electrophilic substitution to specific positions

• Steric Effects: The ortho-methyl group provides steric hindrance that can influence reaction selectivity

Research Applications & Market Significance

• Pharmaceutical Research: Building block for drug discovery programs

• Agrochemical Synthesis: Intermediate for pesticide development

• Organic Synthesis: Versatile intermediate for functionalized aromatic compounds

• Material Science: Used in the preparation of specialty polymers

Quality Specifications

• Purity: ≥98.0% determined by GC

• Boiling point: 181-183°C

• Density: 1.422 g/mL at 25°C

• Refractive index: n²⁰/D 1.556

• Storage: 2-8°C, sealed, protected from light

• Stable for 36 months when properly stored

Packaging & Shipping

• Research quantities: 25g, 100g amber glass bottles

• Bulk quantities: 500g, 1kg amber glass bottles

• Shipped at ambient temperature