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Home > Biochemical Engineering > Polypeptide > Retatrutide for Sale > Retatrutide LY3437943 Synthetic Peptide Lyophilized Powder, Research Grade, CAS 2381089-83-2
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Retatrutide LY3437943 Synthetic Peptide Lyophilized Powder, Research Grade, CAS 2381089-83-2

7394 Inquiries

Unit Price:

$30-34/BOU FOB

Get Latest Price
CAS No.:

2381089-83-2

Grade:

Research Grade

Content:

99%

Port:

guangdong

Brand:

OEM

Packaging:

5mg/vial 10vials/box

Price valid (until):

2027-03-26

Company Type:
Trader
Location:
Hongkong, China
Qualification:
Main Products:

Tirzepatide,Retatrutida

  • Product Description

  • Seller Information

  • Inquiry History

  • Description


      Product Detail  


    Retatrutide is a synthetic 39-amino-acid peptide compound. It is a triple receptor agonist peptide, designed for scientific research study on receptor biology and related preclinical mechanism research.
    Our product is supplied as lyophilized powder, with high purity tested by HPLC. Each batch can provide COA, HPLC report and MSDS for reference. This product is research-grade raw material.
    Important Statement:
    This item is for laboratory research and in-vitro study only. Not a finished drug. Not for human administration, injection, clinical use, diagnostic or therapeutic purposes. Buyers shall confirm local regulatory compliance before purchase and import. 

    Items Specifications
    Appearance White to off-white lyophilized powder
    Purity 99%
    Packing 10vials/box
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      Why Choose Us 


    Professional peptide API and raw material supply
    Bulk Retatrutide availability
    Batch-specific quality control
    HPLC and LC-MS analytical support
    Flexible B2B order quantities
    Customized bulk packaging
    Reliable technical and commercial support
    International B2B supply experience
    Custom peptide synthesis capabilities
    We aim to establish long-term cooperation with qualified pharmaceutical, biotechnology, CRO, analytical and research customers.

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    Important Notice  


    Retatrutide is an investigational compound and is not an FDA-approved drug.
    This listing is for bulk peptide/API material supplied to qualified B2B customers for lawful research, development, analytical or other permitted professional applications, subject to applicable regulations.
    The product is supplied as bulk powder and is not offered as a finished dosage form or for direct consumer use.

    Shop Retatrutide LY3437943 Synthetic Peptide Lyophilized Powder, Research Grade, CAS 2381089-83-2-Detailed Image 13
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      Physicochemical Properties & Handling Guidance


    Solubility: The lyophilized powder can be reconstituted with suitable aqueous buffer according to laboratory experimental protocols. It is recommended to prepare sub-packaged aliquots after reconstitution to avoid repeated freeze-thaw cycles which may cause molecular degradation.
    Storage requirement: Sealed storage at -20℃, protected from light and humidity. Keep away from frequent temperature fluctuation.
    Shelf life: 24 months under recommended storage conditions (unopened vial). Once reconstituted, use within a short period following lab SOP.
    Packaging options: Standard vial packing in 5mg,10mg,15mg,20mg; custom packaging and bulk supply are negotiable for laboratory project demand.

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    Quality Control 


    We adopt standardized peptide purification and inspection process. Each production batch undergoes full analysis: HPLC purity detection, moisture test, residual solvent inspection, endotoxin test and related substance analysis, to guarantee consistent quality and repeatable experimental data for customers’ research projects.

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    Research Background   


    Retatrutide is a single-molecule triple receptor agonist peptide. Compared with single or dual receptor agonist peptide reagents, this molecule can interact with three class B G-protein coupled receptors simultaneously. It is a popular research tool in academic and industrial labs for exploring the interaction between multiple hormone receptor signaling networks. The structural modification design of this peptide has been documented in multiple published preclinical literature for reference in peptide chemistry and molecular pharmacology research.

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    Reconstitution Guide 


    Prepare suitable sterile aqueous buffer such as PBS or acetic acid solution according to your experimental scheme.
    Add buffer solvent slowly to the vial. Do not shake vigorously. Gentle swirling is recommended to dissolve the lyophilized peptide powder.
    After complete dissolution, aliquot the peptide solution into small centrifuge tubes to avoid repeated freeze-thaw cycles.
    Reconstituted solution should be stored at -20℃ or -80℃ based on your experimental requirements.

    Shop Retatrutide LY3437943 Synthetic Peptide Lyophilized Powder, Research Grade, CAS 2381089-83-2-Detailed Image 37
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    ECHEMI Editorial Reference
    Retatrutide is a novel triple agonist peptide of the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR) and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide inhibits human GCGR, GIPR and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively and mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191 and 0.794 nM, respectively. It is an important tool for obesity research.Retatrutide potently activates the GLP-1R signaling pathway to stimulate glucose-dependent insulin secretion through activity at the GIP receptor (GIPR) or the GLP-1R.Retatrutide is a synthetic peptide with glucose-lowering effects. It is an antidiabetic agent against type 2 diabetes (T2D), stimulating insulin and suppressing glucagon secretion in a glucose-dependent manner.Retatrutide was also shown to delay gastric emptying, lower fasting and postprandial glucose concentration, decrease food intake and reduce body weight in patients with type 2 diabetes.
    Retatrutide (LY-3437943) was discovered by the American pharmaceutical company Eli Lilly and Company. It is a triple glucagon hormone receptor agonist (GLP-1, GIP, and GCGR receptors) for obesity. The 2024 Lasker~DeBakey Clinical Medical Research Award has been given to Joel Habener and Svetlana Mojsov for their discovery of a new hormone GLP-1(7-37) and to Lotte Knudsen for her role in developing sustained acting versions of this hormone as a treatment for obesity.

    Basic Info
    Product Name:

    Retatrutide

    Other Name:

    Retatrutide;GIPR/GLP-1R;LY3437943Retatrutide;Retalutide;Retatrutide (sodium salt);Retatrutide RT5;retatrutide 5mg;Retatratide

    CAS No.:

    2381089-83-2

    InChIKeys:

    MLOLQJNKXBNWFW-SAGGEDDASA-N

    Molecular Weight:

    0

    EC Number:

    200-001-8

    Color/Form:

    White lyophilized

    Categories:

    Polypeptide

    Characteristics
    Water Solubility:

    Soluble in water (5mg/ml).

    Storage Conditions:

    -20°C

    Critical Temperature & Pressure:

    -20°C

    Research
    Class:

    Triple agonist — GCGR, GIPR, GLP-1R

    Status:

    Investigational (Phase 3)

    Mechanism:

    Simultaneously activates glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Engineered from the native GIP backbone with amino acid substitutions to confer GCGR and GLP-1R activity.

    EC50 (Human GCGR):

    5.79 nM

    EC50 (Mouse GIPR):

    0.191 nM

    EC50 (Mouse GLP1R):

    0.794 nM

    EC50 (Mouse GCGR):

    2.32 nM

    EC50 (Human GLP1R):

    0.775 nM

    EC50 (Human GIPR):

    0.0643 nM

    Source:

    Jastreboff AM, et al. N Engl J Med. 2023;389(6):514-526.DOI

    Clinical Development:

    NCT04881760; NCT05882045; NCT06354660

    References
    ChEMBL:

    CHEMBL5095485

    DrugBank:

    DB18993

    KEGG DRUG:

    D12430

    PubChem:

    PubChem

    Disclaimer:

    Retatrutide is an investigational compound not yet approved by FDA or EMA. This listing is for industrial and laboratory research use only. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Tirzepatide,Retatrutida

    Location:

    RM 701, UNIT 108, 7/F, TWR B NEW MANDARIN PLAZA 14 SCIENCE MUSEUM RD TSIM SHA TSUI HONG KONG

    Year of Establishment:

    2026

  • Inquiry History
    7394 Inquiries
    Country Product Purchase Quantity Date Posted
    United States

    Retatrutide 2381089-83-2

    3 MT Mar 28, 2026
    United Kingdom

    Retatrutide - 2381089-83-2

    1 G Feb 10, 2026
    United States

    Retatrutide CAS 2381089-83-2 10mg vial

    20 MT Mar 7, 2026
    United States

    Factory Retatrutide API 99% Purity CAS 2381089-83-2

    5 KG Nov 10, 2025
    United Kingdom

    Peptide powder Retatrutide 99% pure for Body building cas 2381089-83-2 Weight Loss Peptide with COA

    1 MT Mar 22, 2026
    United States

    2381089-83-2

    100 MT Dec 9, 2023
    United States

    2381089-83-2

    100 G Jul 14, 2026
    United States

    2381089-83-2

    100 G Feb 24, 2026
    United States

    Retatrutide 2381089-83-2

    200 MG May 16, 2026
    United Kingdom

    2381089-83-2 retatrutide

    300 MG Feb 13, 2026
    United States

    Retatrutide 2381089-83-2 wholesale

    500 MT Nov 3, 2023
    Poland

    CAS 2381089-83-2 (Custom Peptide)

    40 MT Apr 10, 2026
    Austria

    Peptide Retatruide CAS 2381089-83-2

    100 MT Apr 4, 2026
    United States

    Retatrutide CAS 2381089-83-2 99%

    10 PCS Feb 21, 2026
    Austria

    Retatrutide CAS 2381089-83-2 10mg vial

    20 PCS Feb 10, 2026
    United States

    GLP-1 / GIP Retatrutide cas 2381089-83-2

    1 MT Oct 16, 2024
    United States

    Retatrutide 99% High Quality CAS 2381089-83-2

    1 G Jan 23, 2026
    United States

    Injection Peptide Tirzepatide/Retatrutide/ Semaglutide Peptides CAS 2381089-83-2

    10  Oct 21, 2023
    Australia

    GMP Grade 99% Retatrutide Lyophilized Powder CAS 2381089-83-2

    10 G Jun 12, 2026
    Poland

    Factory 99% Purity Retatrutide Peptide CAS 2381089-83-2 Door-To-Door Service

    5 G Feb 22, 2026
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