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Semaglutide CAS 910463-68-2 High Stability Lyophilized Peptide For Non-Clinical Lab Research

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$30-33/BOU FOB

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CAS No.:

910463-68-2

Grade:

Research Grade

Content:

99%

Port:

Guangdong

Brand:

OEM

Packaging:

10mg/vial 10vials/box

Price valid (until):

2026-11-16

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Hong Kong Being Honest Trading Limited

Company Type:

Trader

Location:

Hongkong, China

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Main Products:

Tirzepatide,Retatrutida

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Product Details
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Inquiry History

Description

Basic Product Information

Product Name: Semaglutide

CAS No.: 910463-68-2

Molecular Formula: C₁₈₇H₂₉₁N₄₅O₅₉

Molecular Weight: 4113.58

Peptide Length: 31 amino acid residues

Sequence: H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEA-AEEA-γ-Glu-N-heptadecanedioic acid)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-OH

Structure Feature: Synthetic lipid-modified peptide, Aib (2-aminoisobutyric acid) modification at position 8, C18 fatty di-acid side chain conjugated on the side chain of Lys26 via two AEEA linkers and γ-glutamic acid spacer. The lipid moiety enhances molecular stability in buffer solution for laboratory testing.

Available Package: 10mg/vial,15mg/vial,20mg/vial,30mg. Custom packaging specifications are available upon buyer’s request.

Storage Condition (Unopened): -20℃, sealed, away from light.

Product Form: Lyophilized powder

Category: Research Biochemical / Research Peptide Raw Material

Full Product Description

1. Product Introduction

Semaglutide is a long-chain lipid-modified GLP‑1 analog peptide, consisting of 31 amino acid residues. It contains Aib modification at position 8 and C18 fatty di-acid side chain conjugated to Lys26 via AEEA and gamma-glutamic acid spacers. The finished raw material is prepared via vacuum freeze drying and appears as white to off-white loose lyophilized powder at room temperature. Lyophilization removes water from the peptide sample under low-temperature vacuum, which greatly slows down hydrolytic degradation and preserves peptide integrity during long-term storage.

Long-chain lipid-modified peptides are vulnerable to hydrolysis and degradation under high temperature and high humid conditions. We use refined peptide synthesis, buffer formulation screening and tailored freeze-drying workflow to minimize molecular degradation risk during production and long-term preservation. The whole manufacturing workflow includes raw material inspection, resin loading, peptide chain assembly, cleavage and deprotection, crude peptide precipitation, preparative HPLC purification, desalting, concentration, sterile filtration, freeze-drying and vial sealing. In-process QC testing is implemented in every production step to reduce quality fluctuation. All raw amino acid materials are tested before feeding into production.

After production, each batch undergoes comprehensive QC tests: RP-HPLC, ESI-MS, amino acid composition analysis, water content, residual solvent and impurity profiling. Retained samples are submitted to periodic stability monitoring to verify quality retention within shelf life. We keep batch retention samples for stability tracking. Consistent physicochemical properties help researchers obtain repeatable experimental results.

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2. Core Strengths: Stability & Product Advantages

-Custom freeze-drying process for excellent long-term storage stability
Specially optimized freeze-drying curve reduces residual moisture and protects peptide backbone and lipid side chain against hydrolysis. Under recommended -20℃ sealed dark storage, purity remains stable during the full 24-month shelf life. Low residual moisture limits hydrolytic reaction, leading to low degradation rate and reduces experimental uncertainty caused by raw material quality drift.
-Stable batch-to-batch consistency
Fixed synthesis parameters, purification protocols and lyophilization recipes. Parallel QC and stability inspection for each batch. The same amino acid raw material source, synthesis cycle and purification parameters are adopted for each production run. Minimal quality variation between lots, suitable for long-term continuous research projects, repeated parallel experiments and comparative studies.

-Mature synthesis technology for lipid-modified long-chain peptide

Precise lipid side chain conjugation technology, effectively reducing truncated peptide fragments and reaction by-products generated in peptide assembly. The coupling efficiency of lipid modification is strictly controlled during production, reducing incomplete modification impurities.

-High purity with strict impurity control

HPLC purity ≥98%; optional ≥99% single impurity ≤1.0%, total impurities ≤2.0%. Low impurity background reduces interference for in-vitro biochemical and cell research, helping researchers obtain clean experimental data.

-Vacuum sealed vial packaging to block moisture and oxygen

Borosilicate glass vial with rubber stopper and aluminum cap, vacuum sealed after lyophilization. It effectively isolates ambient moisture and oxygen, further protecting peptide molecular integrity during storage and transportation. The packaging is moisture-proof and light-shielding, reducing external environment impact.

-Complete batch analytical documents and stability archive data

Each shipment comes with batch-specific COA, HPLC chromatogram, ESI-MS spectrum, amino acid analysis report and MSDS. Archived stability test records can be provided upon request for research documentation, thesis writing and project filing.

-Flexible packaging and customizable grades

Multiple vial sizes and bulk quantities available. Low-endotoxin grade can be customized for sensitive cell-level research. Stable production capacity supports trial samples, medium batch and bulk repeat orders. We also support custom labeling service according to buyer requirements.

Product Specifications

Items	Specifications
Appearance	White to off-white lyophilized powder
Sequence Identity	Consistent with target 31aa sequence including Aib modification and C18 lipid side chain
Purity (RP-HPLC, 220nm)	≥99.0%

Items	Specifications
MS Identity	Matches theoretical molecular weight within acceptable mass tolerance
Amino Acid Analysis	Molar ratio of amino acids within acceptable deviation of theoretical composition
Storage Life	24 months under recommended storage

Physicochemical Properties

Solubility: Soluble in purified water, weak acidic aqueous solution and neutral phosphate buffer. The solubility varies slightly depending on buffer pH, concentration and temperature.

Stability Profile: Lyophilized solid has good anti-hydrolysis performance under dry sealed condition. It is sensitive to high temperature, high humidity and repeated freeze-thaw cycles. Exposure to extreme pH will accelerate degradation of lipid side chain. Reconstituted aqueous solution has limited stability and must be used immediately after preparation. Prepared peptide solution is recommended to be stored at -20℃ and avoid repeated freeze-thaw cycles.

Light requirement: Protect from strong UV light and direct sunlight to avoid molecular structural change.

Recommended reconstitution pH: 4.0 ~ 8.0

Molecular Characteristics: Lipidated peptide, surface-active property, long-chain fatty acid side chain brings higher affinity to albumin in in-vitro test environment.

Storage, Shelf Life & Transportation

Storage: Hermetically sealed, stored at -20℃ in dry and dark environment. Keep away from heat, moisture and direct sunlight. Avoid repeated freeze-thaw cycles. Do not open the vial until ready for experiment. Once opened, use quickly and seal tightly for temporary storage.

Shelf Life: 24 months under recommended sealed storage. Stability retention is verified by periodic stability test. Reconstituted solution must be used immediately.

Transportation: Cold chain shipment recommended to avoid temperature fluctuation during transit and preserve peptide stability. Do not ship with oxidants, strong acid and alkali. Handle carefully to prevent vial breakage. Package with shock-proof cushioning to reduce vibration impact during delivery.

Packaging Specifications

Lab vial package:10mg/vial,15mg/vial,20mg/vial. Each vial is vacuum sealed with rubber stopper and aluminum cap, packed in individual shock-proof box.

Bulk package: 50mg,100mg,1g,5g, sealed in aluminium foil bag or custom container.

Package material: Borosilicate glass vial, rubber stopper, aluminum cap, moisture-proof aluminium foil bag, shock-proof foam and carton.

Custom service: Custom labeling, custom container size and custom batch packaging available upon request.

ECHEMI Editorial Reference

Semaglutide (CAS: 910463‑68‑2) is a synthetic lipid‑modified peptide analogue, consisting of a 31‑amino‑acid backbone with a covalently attached C18 fatty di‑acid side‑chain via a hydrophilic spacer. It shares 94% amino‑acid sequence homology with native human GLP‑1 peptide. The substance appears as white to almost white hygroscopic powder, with molecular formula C₁₈₇H₂₉₁N₄₅O₅₉ and molecular weight of 4113.58 g/mol. Structural modifications grant it resistance against DPP‑4 enzymatic degradation and enable reversible binding to serum albumin, contributing to its extended in‑vivo half‑life property.

Certificates

Basic Info

Product Name:

Semaglutide

Other Name:

Sermaglutide;Semaglutide impurity;Sermaglutide USP/EP/BP;semaglutide;Sermaglutide CAS 910463 68 2;Semaglutide (H-7894.0001);semgalutide;Semaglutide

CAS No.:

910463-68-2

Molecular Formula:

C187H291N45O59

InChIKeys:

DLSWIYLPEUIQAV-CCUURXOWSA-N

Molecular Weight:

4113.57754

Exact Mass:

4113.122087 g/mol

EC Number:

203-405-2

Color/Form:

White to off-white

Categories:

Polypeptide

Characteristics

PSA:

1650 Å²

XLogP3:

5.44520

Critical Temperature & Pressure:

Store at -20°C

Research

Class:

GLP-1R agonist

Status:

FDA-approved (Ozempic / Wegovy / Rybelsus)

Mechanism:

Long-acting, selective glucagon-like peptide-1 (GLP-1) receptor agonist with 94% sequence homology to human GLP-1. Engineered for extended half-life (~1 week) via albumin binding (fatty acid acylation at Lys26) and resistance to DPP-4 degradation (Aib substitution at position 8). Promotes insulin secretion, inhibits glucagon release, delays gastric emptying, and reduces appetite via central nervous system GLP-1R activation.

Activity note:

Potent, selective GLP-1R agonist. Reported binding affinity Ki = 0.38 ± 0.06 nM. Semaglutide is a human GLP-1 analog with structural modifications for albumin binding (C18 fatty diacid at Lys26) and enzymatic stability (Aib8 substitution).

Source:

Lau J, et al. J Med Chem. 2015;58(18):7370-7380. Wilding JPH, et al. N Engl J Med. 2021;384(11):989-1002.DOI

Clinical Development:

NCT03548935; NCT03552757; NCT01720446; NCT02692716

FDA:

Ozempic, Wegovy, Rybelsus (approved 2017-12-05)

References

ChEMBL:

DrugBank:

KEGG DRUG:

PubChem:

Literature:

NEJM: Wilding et al. (2021) — STEP-1; NEJM: Marso et al. (2016) — SUSTAIN-6; J Med Chem: Lau et al. (2015) — Discovery of Semaglutide; FDA: Ozempic (NDA 209637)

Disclaimer:

Semaglutide is approved as a prescription medicine (Ozempic, Wegovy, Rybelsus) in certain jurisdictions. This listing is for industrial and laboratory research use only. Research-chemical listings on B2B marketplaces are not interchangeable with approved medicines. Confirm CAS, specification, and regulatory pathway with the seller. It is not medical advice, a clinical recommendation, or an approved therapy description.

See More Semaglutide Properties 

Hazard Identification

Classification of the substance or mixture

Reproductive toxicity, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H361 Suspected of damaging fertility or the unborn child
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Semaglutide Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Tirzepatide,Retatrutida

Location:
RM 701, UNIT 108, 7/F, TWR B NEW MANDARIN PLAZA 14 SCIENCE MUSEUM RD TSIM SHA TSUI HONG KONG

Year of Establishment:
2026

Inquiry History

115 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Weight Loss Semaglutide intermediate 99% White powder COA High Quality peptide GLP-1 910463-68-2	5 MG	Apr 11, 2024
United States	Gene-Biocon Semaglutide 910463-68-2 GLP-1analogs diabetes weight loss 96% White or off-white powder	2	Dec 5, 2023
China	Semaglutide CAS 910463-68-2	1 KG	Apr 16, 2026
Sri Lanka	Bulk Supply 98% up Sermaglutide powder CAS 910463-68-2	300 G	Nov 18, 2023
China	Semaglutide Tirzepatide for Weight Loss CAS: 910463-68-2 Retatrutide Cagrilintide	1 MT	Jul 5, 2025
United States	High Purity IGF-1 LR3 Peptide CAS 910463-68-2 IGF1 LR3	60 MG	Aug 4, 2025
United Kingdom	Manufacturer supply high purity Semaglutide 98% with best price cas 910463-68-2	10 MT	Nov 14, 2023
United States	Manufacturer Supply Weigh Loss Peptide Semaglutide 98% with Best Price CAS 910463-68-2	1	Dec 15, 2023
United Kingdom	Weight Loss GLP-1 Peptides Purity 99% Wholesales Price 2mg 5mg 10mg Semaglutide CAS: 910463-68-2	400	Nov 13, 2023
United Kingdom	l Weight Loss Semaglutide Tirzepatide Epitalon Retatrutide pharma Peptides Liraglutide CAS: 910463-68-2 Retatrutide CAS 2381089-83-2 Ly34379	20 MT	Nov 13, 2023
United States	Tirzepatide	100 MT	Apr 2, 2024
Brazil	Semaglutide	1 KG	Feb 21, 2025
United States	Semaglutide	1000 KG	Sep 30, 2026
Italy	Semaglutide	10 MG	Aug 17, 2026
South Africa	Semaglutide	1 KG	Jun 9, 2026
United States	semaglutide	1000 MT	Mar 26, 2026
United Kingdom	semaglutide	5 MG	Jan 18, 2026
Brazil	Semaglutide	100 G	Nov 5, 2025
United States	Semaglutide	10 G	Sep 25, 2025
Pakistan	Semaglutide	10 MG	Jul 9, 2025

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Semaglutide CAS 910463-68-2 High Stability Lyophilized Peptide For Non-Clinical Lab Research

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