CAS 75921-69-6 MT1 Afamelanotide Lyophilized Powder High Purity Stable Research Peptide

MT1, also known as Melanotan I or Afamelanotide, CAS No.75921-69-6, is a synthetic linear tridecapeptide, a structural analogue of endogenous α-melanocyte-stimulating hormone (α-MSH). Its amino acid sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂. Molecular formula: C₇₈H₁₁₁N₂₁O₁₉, molecular weight:1646.85. Specific amino acid substitution on peptide backbone improves protease resistance, which makes it widely adopted in melanocortin receptor related laboratory research. Our MT1 is produced by mature solid-phase peptide synthesis (SPPS) and delivered as lyophilized powder.

1.Molecular Structure Advantage

Targeted amino acid modification on peptide chain, including Nle substitution at position 4 and D-Phe modification at position7. Acetylated N-terminal and amidated C-terminal protect peptide from aminopeptidase and carboxypeptidase degradation. Compared with native α-MSH, MT1 exhibits significantly stronger anti-enzymatic hydrolysis performance, reducing molecular cleavage risk during research operation.

2 High Purity & Low Impurity Advantage

Strict purification process is adopted to remove truncated peptide fragments, oxidation by-products and residual synthesis reagents. RP-HPLC purity ≥99.0%. Low impurity background greatly reduces non-specific interference in cell and biochemical experiments. Batch impurity profiles keep consistent, ensuring reliable and repeatable research data for continuous research projects.

3 Stable Supply & Flexible Order Advantage

Stable peptide production line ensures continuous supply capacity, effectively avoiding stock shortage risk. We support small trial sample orders and large bulk procurement. Custom packaging scheme can be negotiated according to client laboratory requirements. Fast order processing and shipment arrangement for overseas buyers.

Lyophilization technology is the key to maintain MT1 stability. Freeze-drying removes most free water in peptide powder, inhibiting the two main degradation pathways: peptide hydrolysis and oxidative degradation. We carry out systematic stability investigation according to ICH guidelines, including accelerated stability test and long-term stability test. Test results demonstrate that under specified -20℃ dry and dark storage, purity stays within specification, degradation impurities accumulate slowly. Sealed vial can resist moisture and oxygen invasion. Even during cross-border cold-chain transportation, the molecular integrity and purity can remain stable, lowering quality fluctuation risks caused by long-distance logistics.

Every batch of MT1 follows standardized SOP in synthesis, purification, lyophilization and packaging. Before delivery, each batch completes full QC inspection: appearance check, HPLC purity analysis, MS molecular weight identification, water detection, related impurity analysis. Batch-to-batch variation is strictly controlled. Batch-specific COA certificate is provided with each shipment, supporting laboratory records and audit. All finished products will be rechecked before warehouse-out.

Standard crimp-top amber vial packaging, single vial specification:5mg. Amber glass can block light to reduce photo-oxidation of peptide. Crimp sealing structure isolates oxygen and moisture, further protect lyophilized powder. Products are packed with moisture-proof and shock-proof materials for export. Cold chain packaging is available for long-distance cross-border delivery.

Unopened lyophilized MT1 long-term storage: -20℃, dry environment, protected from light, avoid repeated freeze-thaw cycles. It is recommended to equilibrate vial to room temperature before opening to prevent condensation inside vial. After reconstitution by solvent, peptide solution stability decreases obviously. Reconstituted solution should be stored at 2~8℃, subpackage is recommended to minimize freeze-thaw cycles. Proper storage and handling can maximize retention of product quality and stability.

We provide technical guidance about storage, handling and peptide reconstitution operation. Batch COA documents can be supplied. Our team offers timely communication for product technical inquiries. We strictly follow international export inspection requirements. Once shipment is finished, tracking information can be provided for logistics monitoring.