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4-(Difluoromethyl)-L-leucine 2095886-80-7

Name: 4-(Difluoromethyl)-L-leucine 2095886-80-7
Brand: orient
SKU: pr2610191170
Price: 45 USD
Availability: InStock

2 Inquiries

Unit Price:

$45-56/MT FOB

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CAS No.:

2095886-80-7

Grade:

Industrial Grade

Content:

99%

Port:

Brand:

orient

Packaging:

1KG, 5KG, 25KG

Sample Available:

Yes

Price valid (until):

2028-12-21

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Payment Terms:

100% TT in advance

Average Lead Time:

10 days

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Details
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Inquiry History

Description

Product Name:	Dermorphin
Synonyms:	DERMORPHIN ACETATE;L-Tyr-D-Ala-L-Phe-Gly-L-Tyr-L-Pro-L-Ser-NH2;Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide;Dermorphin trifluoroacetate salt;Dermorphin Powder;(2S)-N-[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide;Dermorphin HAc;(2S)-1-[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-phenyl-propanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]-N-[(1S)-1-carbamoyl-2-hydro
CAS:	77614-16-5
MF:	C40H50N8O10
MW:	802.87
EINECS:	202-853-6
Product Categories:	77614-16-5
Mol File:	77614-16-5.mol

Dermorphin Chemical Properties

Melting point	157-159 °C
Boiling point	1323.8±65.0 °C(Predicted)
density	1.363±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO
form	powder
pka	9.83±0.15(Predicted)
color	white to off-white
Sequence	H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2
InChIKey	FHZPGIUBXYVUOY-VWGYHWLBSA-N
SMILES	C(N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N)(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](N)CC1C=CC(O)=CC=1)CC1C=CC=CC=1)CC1C=CC(O)=CC=1

Safety Information

WGK Germany

MSDS Information

Dermorphin Usage And Synthesis

Structure	Dermorphin does not contain the common N-terminal sequence for the traditional endogenous peptides (Tyr–Gly–Gly–Phe), and its sequence is completely different from those of the endomorphins, which were identified as endogenous μ- peptides that also do not contain the common sequence. Interestingly, DM contains D-alanine (a D-isomer amino acid) in its sequence. The primary structure of dermorphin is YDAFGYPS-NH2.
Description	Dermorphin was first isolated from the skin of the skin of South American frogs of the genus Phyllomedusa. It is a high potency natural opiate peptide that binds selectively to mu- receptors.
Uses	A mu- receptor agonist
Definition	ChEBI: Dermorphin is an oligopeptide.
Side effects	Like μ-opiate agonists, dermorphins produce antinociception and also catalepsy, respiratory depression, constipation, tolerance, and dependence, although at a lower degree than does[1].
in vitro	Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHOhMu, Dermorphin and DeNo displac the binding of [3H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [3H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[35S] in a concentration dependent and saturable manner at the Mu receptor.
References	[1] Negri, L. P. Melchiorri and R. Lattanzi. “ and Bv8 Peptides.”Handbook of Biologically Active Peptides (Second Edition) 2013:376-383.

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

Q4:What if there are quality issues？

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Basic Info

Product Name:

4-(Difluoromethyl)-L-leucine

Other Name:

NV-5138;4-(difluoromethyl)-L-leucine;UNII-06CA9QMG6Z;06CA9QMG6Z;2095886-80-7;CHEMBL4650303;SCHEMBL18762589;EX-A5037;ZINC585143195;NV-5138?

CAS No.:

2095886-80-7

Molecular Formula:

C7H13F2NO2

InChIKeys:

HRFIMCJTDKEPPV-BYPYZUCNSA-N

Exact Mass:

181.09143498

UNII:

06CA9QMG6Z

Categories:

Inhibitor Drugs

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
Lithuania	4-(Difluoromethyl)-L-leucine	2 G	Oct 14, 2026
Lithuania	4-(Difluoromethyl)-L-leucine	10 G	Oct 19, 2026

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4-(Difluoromethyl)-L-leucine 2095886-80-7

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