GHK-Cu Copper Tripeptide Lyophilized Powder CAS 89030-95-5 High Purity Research Raw Material

GHK-Cu, also known as Copper Tripeptide-1, chemical name Glycyl-L-Histidyl-L-Lysine copper(II) complex, CAS No. 89030-95-5, amino acid sequence Gly-His-Lys, molecular formula C₁₄H₂₂CuN₆O₄, molecular weight 401.91 g/mol. It is a coordination complex formed by the tripeptide GHK chelated with divalent copper ion. The physical form of our GHK-Cu product is blue-green lyophilized powder, which is highly soluble in water and aqueous buffer solution. Our raw material screening system is strictly implemented before synthesis. All amino acid monomers, copper salt reagents and buffer auxiliary materials are subject to identity confirmation, purity inspection and heavy metal testing before entering the peptide synthesis workshop. The whole synthesis process adopts solid-phase peptide synthesis route with precise pH control during the chelation reaction, to ensure that copper ions are stably combined with the tripeptide backbone and avoid the generation of free copper ions, unchelated copper salt impurities and peptide fragment deletion impurities. It is clearly stipulated that this product is supplied as research raw material and industrial formulation raw material only. It is not finished pharmaceutical product, oral dietary supplement, finished cosmetic product or direct consumer commodity. It cannot be directly used for human injection, oral administration or clinical treatment. All downstream formulation development, laboratory testing and application work must abide by the regulatory requirements of the region where the buyer is located. Buyers need to independently confirm local import control rules, laboratory use permissions and relevant compliance obligations before placing orders. Our company only undertakes the supply of raw materials, and will not bear any adverse consequences and legal liabilities caused by unauthorized use beyond the scope of laboratory research and raw material formulation development.

We provide diversified packaging options of GHK-Cu to meet different usage scenarios of global customers. Small laboratory trial specifications include 5mg/vial, 10mg/vial, 50mg/vial, 100mg/vial; bulk specifications include 1g, 5g, 10g, 50g, 100g, 1kg, suitable for long-term R&D projects and industrial formulation test. The product purity is ≥99% tested by RP-HPLC, and the molecular structure is verified by MS mass spectrometry. The full inspection list covers appearance, solubility, peptide content, copper chelation rate, water content, residual solvent, related peptide impurities, heavy metal residues and microbial limit test. The copper chelation rate is a core indicator of GHK-Cu, and our production process can maintain a high chelation rate in each batch, effectively reducing free copper content which may interfere with experiments and formula systems. The water content of lyophilized powder is strictly controlled at a low level, residual organic solvents comply with ICH Q3C international reagent standards. Heavy metal items such as lead, arsenic, mercury and cadmium are strictly limited to ultra-low threshold, lowering interference for cell experiments, in vitro mechanism research and formula compatibility evaluation. Each batch of finished goods is equipped with a complete COA certificate of analysis, recording all test item data. We adopt independent vacuum-sealed brown glass vial packaging for small-spec lyophilized powder. The brown bottle can block light, and vacuum sealing isolates moisture and oxygen. Batch number, production date, expiry date and storage reminder are clearly printed on each vial and outer packing box, convenient for laboratory inventory management, batch traceability and experimental record filing. Filling and packaging operations are completed in a low-dust clean area to avoid foreign particulate contamination introduced in the post-production link.

1 High Purity & Controlled Impurity Spectrum

GHK-Cu belongs to metal chelated peptide compound, and the purification difficulty is higher than ordinary linear peptides. Our optimized solid-phase synthesis and post-chelation purification process can effectively remove truncated peptide impurities, deletion sequence peptides, unreacted amino acid raw materials and excess free copper salts. All related impurities are separated and identified during quality control, and impurity peaks are recorded in batch test reports. Many low-grade GHK-Cu products on the market often have problems such as incomplete copper chelation, excessive free copper and unknown peptide impurities. These impurities will cause unstable experimental results, abnormal color change of the solution and poor compatibility in downstream formula screening. We use high-precision liquid chromatography and mass spectrometry for batch release inspection, the test method has passed method verification, and the detection limit and quantification limit meet the testing requirements of high-grade peptide reagents. Customers can obtain clear impurity information before the experiment design, reasonably evaluate the risk of raw materials, reduce invalid repeated experiments caused by poor raw material quality.

2 Outstanding Lyophilized Stability

Stability is the key pain point of copper tripeptide products. GHK-Cu is sensitive to light, high temperature and repeated freeze-thaw cycles. If the process and packaging are not properly controlled, copper ions are easy to dissociate from the peptide skeleton, the peptide chain hydrolyzes and degrades, and the color of the product changes obviously. Our specially developed freeze-drying curve reduces the thermal stress on the peptide molecules during dehydration, minimizing residual moisture in the powder, which greatly slows down the hydrolysis degradation rate of the peptide chain and the dissociation of copper chelate. Combined with brown light-proof vial + vacuum sealing packaging, the finished lyophilized powder can maintain stable peptide structure and copper chelation state under the recommended long-term storage condition. We have carried out systematic stability investigation, including accelerated stability test and real-time long-term stability test. Test samples are regularly sampled and tested under controlled temperature and humidity environment, tracking the changes of purity, chelation rate, moisture and related impurities with storage time. Stability test data can be provided upon customer application, supporting the sorting and archiving of research project documents. Compared with ordinary products that are prone to discoloration and degradation, our GHK-Cu can keep stable quality for a long validity period and reduce the risk of raw material failure during the research cycle.

3 Excellent Batch Consistency

For continuous laboratory research and serial formula development, consistent quality between batches is essential to guarantee repeatable results. All production batches of GHK-Cu strictly follow unified SOP operation standards, including feeding sequence, reaction temperature, chelation pH holding time, elution gradient of chromatographic purification, freeze-drying program parameters. All production parameters are recorded in the production log for traceability. The acceptance standard and detection method of batch release are unified. Once any parameter deviation occurs in the production process, the deviation investigation process will be triggered immediately, and the batch can only be released after evaluation and confirmation that the quality is not affected. The difference range of purity, copper chelation rate, impurity profile and physical color between different batches is strictly controlled. When customers switch batches in continuous research or multi-batch formula tests, they can avoid large fluctuations of experimental and formula data, reduce the heavy workload of repeated method verification and compatibility test caused by raw material difference.

4 Complete Document Support & Flexible Supply Service

We support flexible order arrangements, from small trial orders for preliminary laboratory screening to large bulk supply for industrial pilot formulation. In addition to the standard COA report, we can provide MSDS safety data sheet, HPLC chromatogram, mass spectrum map and TDS technical data sheet, all documents can be provided in English version to meet the document filing requirements of overseas laboratories and R&D institutions. Our technical team can provide standardized guidance for product storage, reconstitution, solvent selection and solution management, remind customers of light protection and freeze-thaw avoidance points in the operation process. For international cross-border logistics, we adopt light-proof, moisture-proof and shock-proof packaging. Cold chain transportation service is optional for customers who need strict low-temperature control. Our stable raw material production line keeps regular specifications in stock, which supports fast delivery and shortens customer procurement cycle. We also support pre-shipment sample testing service; customers can apply for samples to verify quality before bulk order placement. Production archives and batch test records are stored for a long time, which can support customers’ subsequent technical inquiry and batch traceability.

GHK-Cu is mainly used for in-vitro laboratory scientific research and raw material formula development. Common research directions include cell culture related mechanism research, extracellular matrix related research, cytokine regulation research, cell migration model research, tissue remodeling related basic research, formula compatibility screening of cosmetic raw materials and related pre-laboratory exploratory tests. It is widely used in universities, scientific research institutes, biological R&D laboratories and raw material R&D enterprises. It should be emphasized again that this product is research and formulation raw material, not finished product. Without completing the corresponding regulatory approval and safety evaluation, it shall not be directly made into finished cosmetics, finished medicines, oral health products, or used for any human body direct application and clinical trial. Buyers are responsible for evaluating whether the compound matches their own research and development objectives, and take full responsibility for experimental design, formula development and operation risks.

Recommended storage conditions for unopened GHK-Cu lyophilized powder: long-term storage at -20℃, sealed and protected from light; short-term storage can be kept at 2~8℃ refrigerated condition, also away from light and moisture. Avoid repeated freeze-thaw cycles after opening the vial. After reconstitution into aqueous solution, the solution is sensitive to light and oxidation. It is recommended to aliquot the liquid and use it quickly, and avoid long-term storage of the working solution. If the reconstituted solution needs temporary storage, it should be sealed in an opaque container under 2~8℃ refrigeration. During transportation, avoid long-time sunlight exposure and high-temperature environment. For long-distance international shipment, cold chain transport can be selected to maintain stable temperature. The storage environment should be dry, and it is recommended to place desiccant together when storing. Improper storage will accelerate peptide hydrolysis, copper ion dissociation, product discoloration and impurity increase, and directly affect the stability and repeatability of subsequent experiments and formula tests. Our light-proof vacuum packaging reduces the risk of quality change during transportation, but customers still need to follow the storage specifications strictly after receiving the goods.

We provide global after-sales service for overseas purchasers. If customers find broken packaging, leakage, damaged vials or missing batch documents after receiving goods, please contact our sales team within the agreed time window, we will verify the situation and give reasonable solutions. Our sales and technical team can respond to inquiries about specifications, stock status, storage methods, document application and delivery schedule in a timely manner. Conventional specifications maintain continuous stock to support quick shipment and shorten lead time. For large-scale bulk orders, we can arrange production schedule in advance according to customer demand. We support sample service for quality pre-verification before bulk order. Batch production records and inspection reports are archived for a long time to facilitate technical support and traceability in later research projects. We maintain stable production capacity and supply chain to help customers realize long-term and stable raw material procurement.