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Meglumine diatrizoate

Meglumine diatrizoate structure

CAS No:
131-49-7
Formula:
C11H9I3N2O4.C7H17NO5
Chemical Name:
Meglumine diatrizoate
Synonyms:
D-Glucitol,1-deoxy-1-(methylamino)-,3,5-bis(acetylamino)-2,4,6-triiodobenzoate (1:1);Glucitol,1-deoxy-1-(methylamino)-,3,5-diacetamido-2,4,6-triiodobenzoate (salt),D-;D-Glucitol,1-deoxy-1-(methylamino)-,3,5-bis(acetylamino)-2,4,6-triiodobenzoate (salt);Benzoic acid,3,5-diacetamido-2,4,6-triiodo-,compd. with 1-deoxy-1-(methylamino)glucitol;Sorbitol,1-deoxy-1-methylamino-,compd. with 3,5-diacetamido-2,4,6-triiodobenzoic acid;Benzoic acid,3,5-bis(acetylamino)-2,4,6-triiodo-,compd. with 1-deoxy-1-(methylamino)-D-glucitol (1:1);Benzoic acid,3,5-diacetamido-2,4,6-triiodo-,compd. with 1-deoxy-1-methylaminosorbitol;Methylglucamine diatrizoate;Cardiografin;Gastrografin;Hypaque meglumine;Meglumine diatrizoate;Renografin;Diatrizoate meglumine;Ditrizoate methylglucamine;Methylglucamine diacetyldiaminetriiodobenzoate;Renograffin M 76;Meglumine amidotrizoate;Angiografin;Hypaque 60;Diatrizoate methylglucamine;Urovist;3,5-Diacetamido-2,4,6-triiodobenzoic acid methylglucamine salt;Methylglucamine 3,5-diacetamido-2,4,6-triiodobenzoate;Urografic acid methylglucamine salt;Methylglucamine diatrixoate;Hypaque M 30;Methylglucammonium 2,4,6-triiodo-3,5-dipropionamidobenzoate;Renurix;Unipaque;Reno-M-Dip;Hypaque 13.4;Amidotrizoic acid methylglucamine salt;Reno M 60;N-Methylglucamine diatrizoate;Angiovist 282;Angiographin;Angiografin 65;Angiografin 310;Angiografin 60;146-69-0;7170-91-4;19766-67-7;63626-48-2;69426-25-1
Categories:
Organic Chemistry > Amides

Description

Diatrizoate Meglumine is the meglumine salt form of diatrizoate, an organic, iodinated, radiopaque X-ray contrast medium used in diagnostic radiography. The iodine moiety of diatrizoate meglumine is not penetrable by X-rays, therefore blocks the X-ray film exposure by radiation. This makes it possible to distinguish on X-ray film, body parts that contain diatrizoate meglumine from body parts that do not contain this agent and allows for visualization of different body structures.|A versatile contrast medium used for DIAGNOSTIC X-RAY RADIOLOGY.

Meglumine diatrizoate Basic Attributes

Molecular Weight：

809.13

Exact Mass：

808.880310

EC Number：

205-024-7

UNII：

3X9MR4N98U

NCI Thesaurus Code：

C29247

Characteristics

PSA：

215.66000

XLogP3：

1.44700

Density：

1.9465 (estimate)

Melting Point：

189-193° (dec)

Boiling Point：

614.1ºC at 760mmHg

Toxicity：

Intravenous-rat LD50: 15300 mg/kg; Intravenous-mouse LD50: 21200 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxides and iodide fumes

Safety Information

Transport codes：

NONH for all modes of transport

RTECS Number：

LZ4315000

Storage features：

Treasury is ventilated, low temperature and dry; stored separately from food materials

Toxicity

Toxicity class：

practically nontoxic

Drug Information

MeSH：

Substances used to allow enhanced visualization of tissues. (See all compounds classified as Contrast Media.)

MeSH Entry Terms：

Amidotricoic Acid

Meglumine diatrizoate Use and Manufacturing

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:809.1
Hydrogen Bond Donor Count:9
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:9
Exact Mass:808.8803
Monoisotopic Mass:808.8803
Topological Polar Surface Area:209
Heavy Atom Count:33
Complexity:525
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Same as sodium diatrizoate.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Compound diatrizoate meglumine injection
Ingredients	This product is a compound preparation, and its components are: 1 part of sodium diatrizoate and 6.6 parts of diatrizoate meglumine plus an appropriate amount of sodium hydroxide to make a sterile aqueous solution, and the total amount of sodium diatrizoate (C11H8I3N2NaO4) and diatrizoate meglumine (C11H9I3N2O4C7H17NO5) should be 90.0%-110.0% of the labeled amount. Each injection contains 32mg of sodium diatrizoate and 268mg of diatrizoate meglumine.
Indication	1. Intravascular injection of this product immediately after taking cholecystography contrast agent will increase the toxic effect on the kidneys, especially in patients with impaired liver function. 2. Although the use of vasopressors during aortic angiography can improve the contrast of the imaging, due to the contraction of visceral blood vessels, a large amount of contrast agent is forced to enter the spinal cord blood vessels, which increases the neurotoxicity of this product and may cause paraplegia. 3. This product should not be mixed with antihistamines for injection. It may precipitate when mixed with promethazine hydrochloride, diphenhydramine hydrochloride, chlorpheniramine maleate (chlorpheniramine), etc.
Specifications	20ml:12g based on the total amount of diatrizoate meglumine and diatrizoate sodium
Manufacturer	Shanghai Xudong Haipu Pharmaceutical Co., Ltd.

Compound diatrizoate meglumine injection
Ingredients	This product is a compound preparation, its components are: 1 part of sodium diatrizoate and 6.6 parts of diatrizoate meglumine plus appropriate amount of sodium hydroxide to make a sterile aqueous solution, the total amount of sodium diatrizoate (C11H8I3N2NaO4) and diatrizoate meglumine (C11H9I3N2O4·C7H17NO5) should be 90.0%-110.0% of the labeled amount. Each injection contains 32mg of sodium diatrizoate and 268mg of diatrizoate meglumine.
Indication	1. Intravascular injection of this product immediately after taking cholecystography contrast agent will increase the toxic effect on the kidneys, especially in patients with impaired liver function. 2. Although the use of vasopressors during aortic angiography can improve the contrast of the imaging, due to the contraction of visceral blood vessels, a large amount of contrast agent is forced to enter the spinal cord blood vessels, which increases the neurotoxicity of this product and may cause paraplegia. 3. This product should not be mixed with antihistamines for injection. It may precipitate when mixed with promethazine hydrochloride, diphenhydramine hydrochloride, chlorpheniramine maleate (chlorpheniramine), etc.
Specifications	20ml: 15.2g based on the total amount of diatrizoate and sodium diatrizoate

Compound diatrizoate meglumine injection
Ingredients	60% contains 292mg/ml iodine, and 76% contains 370mg/ml iodine.
Indication	1. Intravascular injection of this product immediately after taking cholecystography contrast agent will increase the toxic effect on the kidneys, especially in patients with impaired liver function. 2. Although the use of vasopressors during aortic angiography can improve the contrast of the imaging, due to the contraction of visceral blood vessels, a large amount of contrast agent is forced to enter the spinal cord blood vessels, which increases the neurotoxicity of this product and may cause paraplegia. 3. This product should not be mixed with antihistamines for injection. It may precipitate when mixed with promethazine hydrochloride, diphenhydramine hydrochloride, chlorpheniramine maleate (chlorpheniramine), etc.
Specifications	1ml:0.3g
Manufacturer	Xi`an Han Feng Pharmaceutical Co., Ltd.

Registered Holders

HONOUR LAB LTD

United States
Active
BIOPHORE INDIA PHARMACEUTICALS PVT LTD

United States
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Vasudha Pharma Chem Ltd

United States
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