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Carbetocin

Carbetocin structure

CAS No:
37025-55-1
Formula:
C45H69N11O12S
Chemical Name:
Carbetocin
Synonyms:
BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, (SULFIDE BOND BETWEEN BUTYRYL-4-YL AND CYS);BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2 TRIFLUOROACETATE SALT;(BUTYRYL1,TYR(ME)2)-1-CARBAOXYTOCIN TRIFLUOROACETATE SALT;(BUTYRYL1,TYR(ME)2)-OXYTOCIN;(BUTYRYL1,TYR(ME)2)-OXYTOCIN TRIFLUOROACETATE SALT;CARBETOCIN;CARBETOCIN TRIFLUOROACETATE SALT;(2-O-METHYLTYROSINE)-DE-AMINO-1-CARBAOXYTOCIN
Categories:
Biochemical Engineering > Polypeptide

Description

Carbetocin (Lonactene; Duratocin) is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth; an agonist at peripheral oxytocin receptors.

Carbetocin is an alternative synthetic oxytocin-receptor agonist available in Canada, the United Kingdom, and other countries，but not the United States. A large multinational randomized noninferiority trial (N=29,645) found that carbetocin was noninferior to oxytocin for prevention of postpartum hemorrhage and need for additional uterotonic agents after vaginal delivery. Carbetocin has a longer duration of action than oxytocin, eliminating the need for prolonged infusion.

ChEBI: Oxytocin in which the hydrogen on the phenolic hydroxy group is substituted by methyl, the amino group on the cysteine residue is substituted by hydrogen, and the sulfur of the cysteine residue is replaced by a methylene group. A synthetic carba-analogue o oxytocin, it is used to control bleeding after giving birth. Like oxytocin, it causes contraction of the uterus.

Carbetocin Basic Attributes

Molecular Weight：

988.16

Exact Mass：

987.484802

EC Number：

253-312-6

Color/Form：

white to beige

Characteristics

PSA：

387.81000

XLogP3：

-3.59

Appearance：

white to beige

Density：

1.218±0.06 g/cm3(Predicted)

Melting Point：

140 - 160°C

Boiling Point：

1477.9±65.0 °C(Predicted)

Flash Point：

847.6±34.3 °C

Refractive Index：

1.533

Water Solubility：

Soluble to 29.65 mg/ml in water

Storage Conditions：

-15°C

Specific rotation：

D -69.0° (c = 0.25 in 1M acetic acid)

PKA：

13.07±0.70(Predicted)

Critical Temperature & Pressure：

-15°C

Safety Information

wgk germany：

Storage features：

Store at -20°C

GHS Classification：

|Warning|H312+H332 (100%): Harmful in contact with skin or if inhaled [Warning Acute toxicity, dermal; acute toxicity, inhalation]|P201, P202, P261, P271, P272, P280, P281, P302+P352, P304+P312, P304+P340, P308+P313, P312, P321, P322, P333+P313, P363, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Carbetocin Use and Manufacturing

An obstetric drug used to control postpartum hemorrhaging.

Carbetocin is an obstetric drug used to control postpartum hemorrhaging.A new synthetic analog of oxytocin, carbetocin, is long acting and also has a rapid onset of action. It is an oxytocin receptor agonist and also stimulates milk let down due to its action on oxytocin receptors of myoepithelial cells.

Computed Properties

Molecular Weight:1048.2
Hydrogen Bond Donor Count:11
Hydrogen Bond Acceptor Count:15
Rotatable Bond Count:18
Exact Mass:1047.50591722
Monoisotopic Mass:1047.50591722
Topological Polar Surface Area:425
Heavy Atom Count:73
Complexity:1880
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

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Carbetocin
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Registered Holders

Hybio Pharmaceutical (Wuhan) Co., Ltd.

China
Active
Harbin Jixianglong Biotechnology Co., Ltd.

China
Active
Chengdu Shengnuo Biopharm Co., Ltd.

China
Active

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Guide of Carbetocin

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
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Carbetocin

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