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1-(CYCLOPROPANECARBONYL)PIPERAZINE97

1-(CYCLOPROPANECARBONYL)PIPERAZINE97 structure

CAS No:
59878-57-8
Formula:
C8H14N2O
Chemical Name:
1-(CYCLOPROPANECARBONYL)PIPERAZINE97
Synonyms:
1-(CYCLOPROPANECARBONYL)PIPERAZINE97;1-(Cyclopropylcarbonyl)piperazine, 97%;Piperazine, 1-(cyclopropylcarbonyl)- (9CI);1-(Cyclopropylcarbonyl)piperazine hydrochloride 97%;Cyclopropyl(piperazin-1-yl)methan-1-one hydrochloride;Piperazine, 1-(cyclopropylcarbonyl)-;N-(Cyclopropylcarbonyl)piperazine;1-(Cyclopropylcarbonyl)piperazine, 97%colorless to pale brown liquid
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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1-(CYCLOPROPANECARBONYL)PIPERAZINE97 Basic Attributes

Molecular Weight：

154.20956

Exact Mass：

154.110611

Characteristics

PSA：

32.3

XLogP3：

-0.5

Appearance：

Colorless to pale brown Liquid

Density：

1.087 g/mL at 25 °C

Boiling Point：

120 °C0.15 mm Hg

Flash Point：

>230 °F

Refractive Index：

n20/D 1.524

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

37/38-41

safety instructions：

26-36/37/39

Marks：

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

H315-H318-H335

GHS Classification：

|Danger|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P332+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 44 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

1-(CYCLOPROPANECARBONYL)PIPERAZINE97 Use and Manufacturing

1-Tertbutoxycarbonyl-4-(cyclopropanecarbonyl) piperazine (190 mg, 0.75 mmol) was dissolved in dichloromethane, and then trifluoroacetic acid (1 mL) was added. The reaction mixture was stirred at room temperature until complete reaction, and then washed with saturated sodium bicarbonate solution for three times. The organic phases were concentrated to give 112 mg (yield 97percent) pale yellow solid of N-(cyclopropanecarbonyl) piperazine for use.1 -Tertbutoxycarbonyl-4-(cyclopropanecarbonyl)piperazine (190 mg, 0.75 mmol) was dissolved in dichloromethane, and then trifluoroacetic acid (1 mE) was added. The reaction mixture was stirred at room temperature until complete reaction, and then washed with saturated sodium bicarbonate solution for three times. The organic phases were concentrated to give 112mg (yield 97percent) pale yellow solid of N-(cyclopropanecarbonyl) piperazine for use.In 100 mL of ethanol was dissolved benzyl 4-(cyclopropylcarbonyl)piperazine-1-carboxylate (3.00 g, 10.4 mmol), and 1.5 g of 10percent palladium-carbon was added thereto, followed by stirring at room temperature under hydrogen atmosphere overnight. The palladium-carbon was removed by filtration, and the filtrate was evaporated to give the title compound (1.50 g, 97.3percent) as a colorless oil.1H-NMR Spectrum (CDCl3, 400MHz) δ(ppm): 0.73-0.80(2H, m), 0.96-1.03(2H, m), 1.67-1.77(1H, m), 2.82-2.97(4H, m), 3.60-3.71 (4H, m).10percent Palladium on carbon (175 mg, 10percent by wt.) was placed under an inert atmosphere and suspended in EtOH (5 mL). A solution of (4-benzyl-piperazin-1-yl)-cyclopropyl- methanone (1.75 g, 7.16 mmol) dissolved in EtOH (25 mL) was added. The reaction mixture was placed under H

Computed Properties

Molecular Weight:154.21
XLogP3:-0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:154.110613074
Monoisotopic Mass:154.110613074
Topological Polar Surface Area:32.3
Heavy Atom Count:11
Complexity:160
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 59878-57-8

Grade: Pharmaceutical Grade

Content: 99%

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1-(Cyclopropylcarbonyl)piperazine

CAS No.: 59878-57-8

Content: 99.00%

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Guide of 1-(CYCLOPROPANECARBONYL)PIPERAZINE97

Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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1-(CYCLOPROPANECARBONYL)PIPERAZINE97

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