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2-Amino-6-methylpyridine

2-Amino-6-methylpyridine structure

CAS No:
1824-81-3
Formula:
C6H8N2
Chemical Name:
2-Amino-6-methylpyridine
Synonyms:
2-Pyridinamine,6-methyl-;2-Picoline,6-amino-;6-Methyl-2-pyridinamine;2-Amino-6-picoline;6-Amino-2-picoline;2-Amino-6-methylpyridine;6-Amino-2-methylpyridine;6-Methyl-2-pyridylamine;6-Methyl-2-aminopyridine;6-Methylpyridin-2-ylamine;NSC 1488;NSC 176163;NSC 6971;6-Methylpyridin-2-amine
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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Description

YELLOWISH CRYSTALLINE LOW MELTING SOLID

2-Amino-6-methylpyridine Basic Attributes

Molecular Weight：

108.14

Exact Mass：

108.14

BRN：

107048

EC Number：

217-360-1

UNII：

35ANN6MRBM

NSC Number：

6971|1488

DSSTox ID：

DTXSID0044860

HScode：

29333999

Characteristics

PSA：

38.9

XLogP3：

0.4

Appearance：

Yellow Crystalline Low Melting Solid

Density：

1.0275 (estimate)

Melting Point：

41 °C

Boiling Point：

208.5 °C

Flash Point：

218 °F

Refractive Index：

1.5560 (estimate)

Water Solubility：

very faint turbidity

Storage Conditions：

Store below +30°C.

Vapor Pressure：

0.213mmHg at 25°C

Toxicity：

Oral-rat LD50: 100 mg/kg; Subcutaneous-mouse LD50: 52 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxide fumes

Safety Information

Packing level：

Hazard category：

6.1

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

25-36/37/38-24/25-23/24/25-24

safety instructions：

26-36/37/39-45-37/39-28A

RTECS Number：

US1885000

Marks：

Storage features：

Warehouse ventilated, low temperature and dry

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261-P280-P301 + P310-P302 + P350-P305 + P351 + P338-P310

Hazard Statements：

H301-H310-H315-H319-H335

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P262, P264, P270, P271, P280, P301+P310, P302+P350, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 58 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

highly toxic

2-Amino-6-methylpyridine Use and Manufacturing

Methods of Manufacturing

Derived from 2-methylpyridine amination. Pass liquid ammonia into the reaction tank, add high-speed nitrate iron, slowly add small pieces of metallic sodium in portions with stirring, and continue stirring for 3 hours after the addition. The ammonia is discharged naturally until the reaction solution is in the form of a thin slurry to obtain sodium ammonia solution. Anhydrous xylene was added to sodium amide, stirred and heated to remove residual ammonia gas. The temperature was raised to 120°C and 2-methylpyridine was added dropwise. After the addition was completed, the reaction was maintained at 124-129°C for 10 hours. Slowly add appropriate amount of water to hydrolyze at 90-100℃. After the hydrolysis is completed and stir for half an hour, the xylene layer is separated by standing, xylene is recovered by distillation, and then the 90-120℃ (1.33-2.67kPa) fraction is collected by vacuum distillation, which is 2 -Amino-6-picoline. The yield is 72%.

Uses

Intermediate.

Manufacturing Info：

2-Pyridinamine, 6-methyl-: ACTIVE

Computed Properties

Molecular Weight:108.14
XLogP3:0.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:108.068748264
Monoisotopic Mass:108.068748264
Topological Polar Surface Area:38.9
Heavy Atom Count:8
Complexity:72.9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

2-Methylpyridine

Ammonia

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