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2-Hydrazinoquinoline

2-Hydrazinoquinoline structure

CAS No:
15793-77-8
Formula:
C9H9N3
Chemical Name:
2-Hydrazinoquinoline
Synonyms:
Quinoline,2-hydrazinyl-;Quinoline,2-hydrazino-;2(1H)-Quinolinone,hydrazone;2-Hydrazinylquinoline;2-Hydrazinoquinoline;2-Quinolylhydrazine;α-Quinolylhydrazine;(2-Quinolinyl)hydrazine;NSC 525792
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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2-Hydrazinoquinoline Basic Attributes

Molecular Weight：

159.19

Exact Mass：

159.19

EC Number：

239-899-1

NSC Number：

525792

DSSTox ID：

DTXSID4065945

HScode：

2933990090

Characteristics

PSA：

50.9

XLogP3：

1.3

Density：

1.25±0.1 g/cm3(Predicted)

Melting Point：

142 °C (approx) @ Solvent: Benzene

Boiling Point：

303.1±45.0 °C(Predicted)

Flash Point：

184.4±20.4 °C

Refractive Index：

1.758

Water Solubility：

Soluble in methanol.

Safety Information

hazard class code：

20/21/22-36/37/38-41-22

safety instructions：

26-36/37/39-39

Marks：

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H302

GHS Classification：

|Danger|H302 (90.91%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 44 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

2-Hydrazinoquinoline Use and Manufacturing

Methods of Manufacturing

21.0 g (128.4 mmol) of 2-chloroquinoline are initially charged in 210 ml of ethanol. 64.3 g (1.3 mol) of hydrazine hydrate are added, and the mixture is stirred under reflux for 16 h. The mixture is then cooled to 0° C., and the solid formed is filtered off and washed with a little ethanol. The product is initially air-dried and then dried under high vacuum.Yield: 14.5 g (71percent of theory)LC-MS (Method 1): RA suspension of 2-chloroquinoline (1.50 g, 9.17 mmol) in hydrazine monohydrate (3 mL, 61.85 mmol) wasstirred under reflux for 2 h. The orange solid formed was collectedby filtration, washed with 100 mL of water and dried in vacuo. C9H9N3 (159.19): calcd. C 67.90, H 5.70, N26.40; found C 67.50, H 5.64, N 26.30.

Manufacturing Info：

Quinoline, 2-hydrazinyl-: INACTIVE

Computed Properties

Molecular Weight:159.19
XLogP3:1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:159.079647300
Monoisotopic Mass:159.079647300
Topological Polar Surface Area:50.9
Heavy Atom Count:12
Complexity:149
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes