 Home > Encyclopedia > Dexetimide

Dexetimide

Dexetimide structure

CAS No:
21888-98-2
Formula:
C23H26N2O2
Chemical Name:
Dexetimide
Synonyms:
[3,4′-Bipiperidine]-2,6-dione,3-phenyl-1′-(phenylmethyl)-,(3S)-;[3,4′-Bipiperidine]-2,6-dione,3-phenyl-1′-(phenylmethyl)-,(S)-;Glutarimide,2-(1-benzyl-4-piperidyl)-2-phenyl-,(S)-(+)-;(3S)-3-Phenyl-1′-(phenylmethyl)[3,4′-bipiperidine]-2,6-dione;Dexetimide;Dexbenzetimide;(+)-2-(1-Benzyl-4-piperidyl)-2-phenylglutarimide;(+)-Benzetimide;(S)-(+)-Dexetimide
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Dexetimide ((+)-Benzetimide) is a high-affinity muscarinic receptor antagonist and a potent and persistent anticholinergic agent used to treat neuroleptic-induced parkinsonism[1].

Dexetimide is a member of piperidines.|A muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Benzetimide is the (-)-enantimorph of dexetimide.

Dexetimide Basic Attributes

Molecular Weight：

362.46

Exact Mass：

362.46

EC Number：

244-633-2

UNII：

43477QYX3D

ATC Code：

N - Nervous system

Characteristics

PSA：

49.4

XLogP3：

4.34190

Density：

1.178g/cm3

Melting Point：

181-183 °C

Boiling Point：

543.9ºC at 760 mmHg

Flash Point：

282.7ºC

Refractive Index：

1.597

Specific rotation：

D20 +125° (chloroform)

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

Drug Information

MeSH：

Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)|Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)|Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)

MeSH Entry Terms：

Benzetimide

Dexetimide Use and Manufacturing

Anticholinergic.

Computed Properties

Molecular Weight:362.5
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:362.199428076
Monoisotopic Mass:362.199428076
Topological Polar Surface Area:49.4
Heavy Atom Count:27
Complexity:529
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes