Atropine sulfate monohydrate
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Atropine sulfate monohydrate
structure -
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CAS No:
5908-99-6
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Formula:
C17H23NO3.1/2H2O4S.1/2H2O
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Chemical Name:
Atropine sulfate monohydrate
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Synonyms:
Benzeneacetic acid,α-(hydroxymethyl)-,(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester sulfate,hydrate (2:1:1);1αH,5αH-Tropan-3α-ol,(±)-tropate (ester),sulfate (2:1),hemihydrate;Benzeneacetic acid,α-(hydroxymethyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester endo-(±)-,sulfate (2:1) (salt),monohydrate;Benzeneacetic acid,α-(hydroxymethyl)- (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester,sulfate (2:1) (salt),monohydrate;Atropine sulfate hydrate;Atropine sulfate monohydrate;Atrospan
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CAS No:
Description
Atropine sulfate monohydrate is a competitive muscarinic acetylcholine receptor antagonist.Target: mAChRAtropine is a naturally occurring tropane alkaloid extracted from deadly nightshade (Atropa belladonna), Jimson weed (Datura stramonium), mandrake (Mandragora officinarum) and other plants of the family Solanaceae. Atropine is a competitive antagonist of the muscarinic acetylcholine receptors (acetylcholine being the main neurotransmitter used by the parasympathetic nervous system). At
Atropine sulfate monohydrate Basic Attributes
694.84
694.313532 g/mol
6109275
200-235-0
DTXSID3040724
29399900
Characteristics
191.75000
4.10130
white Powder
189-192 °C (A)(lit.)
429.8ºC at 760mmHg
213.7ºC
H2O: soluble 2.5g/mL (stable for several days at 4°C.)
Poison room
-0.6 º (per USP 25 ºC)
Safety Information
II
6.1
UN 1544 6.1/PG 2
2
26/28-43-36/37/38
23-45-36/37/39-26-1-25
CK2455000
T+
Stable under normal temperatures and pressures.
P260-P264-P284-P301 + P310-P310
H300 + H330
|Danger|H300 (97.3%): Fatal if swallowed [Danger Acute toxicity, oral]|P260, P264, P270, P271, P284, P301+P310, P304+P340, P310, P320, P321, P330, P403+P233, P405, and P501|Aggregated GHS information provided by 111 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Computed Properties
Molecular Weight:694.8
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:10
Exact Mass:694.31353159
Monoisotopic Mass:694.31353159
Topological Polar Surface Area:184
Heavy Atom Count:48
Complexity:434
Undefined Atom Stereocenter Count:6
Covalently-Bonded Unit Count:4
Compound Is Canonicalized:Yes
Drug Function and Efficacy
It inhibits the activity of smooth muscles and glands innervated by postganglionic cholinergic nerves, and can stimulate or inhibit the central nervous system depending on the dosage of this product. The detoxification system antagonizes the effects of cholinesterase inhibitors at the M cholinergic receptor site, such as increasing the secretion of mucous glands and salivary glands in the trachea and bronchial system, contracture of bronchial smooth muscles, and hyperactivity of autonomic ganglia after stimulation. In addition, atropine can excite or inhibit the central nervous system, with a certain dose dependence. The effect on the heart, intestines and bronchial smooth muscles is stronger and more lasting than other belladonna alkaloids.
Registered Holders
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SS PHARMA LLC
Active
United States
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桂化学株式会社
Active
Japan
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Guangzhou Tosun Pharmaceutical Ltd
Active
China
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