ANISODAMINE HYDROBROMIDE
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ANISODAMINE HYDROBROMIDE
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CAS No:
55449-49-5
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Formula:
C7H10BrNO
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Chemical Name:
ANISODAMINE HYDROBROMIDE
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Synonyms:
6-hydroxyhyoscyamine;anisodamine;anisodamine hydrobromide;racanisodamine;UNII-4RKP5CSA1O;4RKP5CSA1O;Anisodamine (hydrobromide);Anisodamine HBr;HY-N0584A
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CAS No:
Description
Anisodamine hydrobromide (6-Hydroxyhyoscyamine hydrobromide), a belladonna alkaloid, is a non-subtype-selective muscarinic, and also a nicotinic cholinoceptor antagonist. Anisodamine hydrobromide employs in traditional Chinese medicine for many ailments, mainly to improve the microcirculation in states of shock, and also in organophosphate poisoning[1].
Drug Information
Drugs that selectively bind to and activate alpha adrenergic receptors. (See all compounds classified as Adrenergic alpha-Agonists.)|Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)|Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)|Substances that eliminate free radicals. Among other effects, they protect PANCREATIC ISLETS against damage by CYTOKINES and prevent myocardial and pulmonary REPERFUSION INJURY. (See all compounds classified as Free Radical Scavengers.)|Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)
6-hydroxyhyoscyamine
Computed Properties
Molecular Weight:386.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:385.08887
Monoisotopic Mass:385.08887
Topological Polar Surface Area:70
Heavy Atom Count:23
Complexity:396
Defined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Anticholinergic drugs acting on M-cholinergic receptors have obvious peripheral anticholinergic effects, can relax smooth muscles, relieve microvascular spasms, and thus have antispasmodic, analgesic and microcirculatory effects. Its effect of dilating pupils and inhibiting glandular secretion is 1/20 to 1/10 of that of atropine. Because it cannot pass through the blood-brain barrier, its central effect is weaker. Compared with atropine, it has the advantages of higher selectivity and lower toxicity and side effects.
Registered Holders
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Chengdu Shidai No.1 Pharmaceutical Co., Ltd.
Active
China
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Guangxi Minglei Weisheng Pharmaceutical Co., Ltd.
Inactive
China
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