4-CHLORO-5-METHOXYPYRIDAZIN-3(2H)-ONE

Synthesis of 4-chloro-5-methoxypyridazin-3(2HVone (10) 4 10 To a solution of compound 4 (4.1 g, 24.8 mmol) in CHJOH (50 mL) was added CH'ONa (2.6 g, 74.5 mmol). The solution was stirred at 80 °C overnight. The mixture was concentrated under reduced pressure, purified by column chromatography [eiuting with PE to PE/DCM/MeOH (10: 1 : 1)] to give 10 (1.2 g, 30percent) as a white solid. Synthesis of 4-chloro-2-(2-chlorobenzylV5-methoxypyridazin-3(2HVone (11To a suspension of 4, 5-dichloro-2-hydroxypyradizine (5.00 g, 30.3 mmol) in methanol (90 mL) at room temperature, sodium methoxide (30percent in methanol, 32.8 mL, 182 mmol) was added. The mixture was heated to reflux for 2 days then was concentrated to dryness. The residue was dissolved in water and acidified with glacial acetic acid. The white precipitate that formed was collected by filtration, washing with water. The solid was dried under vacuum to give 4-chloro-5-methoxypyridazin-3(2H)-one (29-1, 2.99 g).

Molecular Weight:160.56
XLogP3:0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:160.0039551
Monoisotopic Mass:160.0039551
Topological Polar Surface Area:50.7
Heavy Atom Count:10
Complexity:222
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes