 Home > Encyclopedia > 1-PHENYLPIPERAZINE

1-PHENYLPIPERAZINE

1-PHENYLPIPERAZINE structure

CAS No:
63921-23-3
Formula:
C10H14N2
Chemical Name:
1-PHENYLPIPERAZINE
Synonyms:
LABOTEST-BB LTBB000705;AKOS BBS-00003581;TIMTEC-BB SBB003943;1-phenylpiperidin-4-amine(SALTDATA: 2HCl);1-phenyl-4-Piperidinamine;4-Piperidinamine, 1-phenyl-,hydrochloride (1:2);63921-23-3
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Request for Quotation

1-PHENYLPIPERAZINE Basic Attributes

Molecular Weight：

162.23

Exact Mass：

176.131348

EC Number：

202-165-6

DSSTox ID：

DTXSID10611287

HScode：

2933399090

Characteristics

PSA：

29.3

XLogP3：

2.7

Density：

1.062 g/mL at 25 °C(lit.)

Boiling Point：

286 °C(lit.)

Flash Point：

>230 °F

Refractive Index：

n20/D 1.588(lit.)

Safety Information

Transport codes：

UN 2922 8/PG 2

wgk germany：

hazard class code：

22-24-34

safety instructions：

26-36/37/39-45

RTECS Number：

TM2625000

Marks：

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

1-PHENYLPIPERAZINE Use and Manufacturing

A solution of Intermediate'A' (200 mg, 0.55 mmol), l-phenylpiperidin-4-amine (100 mg, 0.57 mmol, 1.00 equiv), and Et3N (168 mg, 1.66 mmol) in CH2CI2 (5 mL) was stirred overnight at rt, then quenched by the addition of H2O and extracted with EtOAc. The combined organic layers were concentrated under vacuum to afford 150 mg (64%) of the title compound as a white solid. LC-MS (ES, m/z): 427.5

Computed Properties

Molecular Weight:176.26
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:176.131348519
Monoisotopic Mass:176.131348519
Topological Polar Surface Area:29.3
Heavy Atom Count:13
Complexity:144
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes