6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-3-METHANOL

Intermediate C6-Chloro-imidazo[1 , 2-b]pyridazine-3-carbaldehyde I Intermediate C(6-Chloro-imidazo[1 , 2-b]pyridazin-3-yl)-methanol (i) To a solution of 6-chloroimidazo[1 , 2-b]pyridazine (1.5 g, 9.8 mmol) in AcOH (50 ml.) was added NaOAc (1.4 g, 17.1 mmol) and paraformaldehyde (1.5 g). The mixture was heated at reflux overnight and then concentrated under reduced pressure. The residue was basified to pH = 12. Then the mixture was filtered and the solid was washed with EtOH to afford (6- chloro-imidazo[1 , 2-b]pyridazin-3-yl)-methanol (1.3 g) in 72percent yield.To a solution of 6-chloroimidazo[1 , 2-b]pyridazine (1 .5 g, 9.8 mmol) in AcOH (50 ml_) was added NaOAc (1 .4 g, 17.1 mmol) and paraformaldehyde (1.5 g). The mixture was heated at reflux overnight and concentrated under reduced pressure. The residue was basified to pH 12. Then the mixture was filtered and the solid was washed with EtOH to afford (6-chloro- imidazo[1 , 2-b]pyridazin-3-yl)-methanol (1.3 g) in 72percent yield.

Molecular Weight:183.59
XLogP3:0.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:183.0199395
Monoisotopic Mass:183.0199395
Topological Polar Surface Area:50.4
Heavy Atom Count:12
Complexity:169
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes