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Mosapramine

Mosapramine structure

CAS No:
89419-40-9
Formula:
C28H35ClN4O
Chemical Name:
Mosapramine
Synonyms:
Spiro[imidazo[1,2-a]pyridine-3(2H),4′-piperidin]-2-one,1′-[3-(3-chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]hexahydro-;Spiro[imidazo[1,2-a]pyridine-3(2H),4′-piperidin]-2-one,1′-[3-(3-chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]hexahydro-,(±)-;5H-Dibenz[b,f]azepine,spiro[imidazo[1,2-a]pyridine-3(2H),4′-piperidin]-2-one deriv.;1′-[3-(3-Chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]hexahydrospiro[imidazo[1,2-a]pyridine-3(2H),4′-piperidin]-2-one;Clospipramine;Mosapramine;123435-19-8;1071658-95-1
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Mosapramine is a racemate comprising equimolar amounts of (R)- and (S)-mosapramine. It is a second-generation antipsychotic used for the treatment of schizophrenia. It has a role as a second generation antipsychotic and a dopaminergic antagonist. It contains a (S)-mosapramine and a (R)-mosapramine.

Mosapramine Basic Attributes

Molecular Weight：

479.06

Exact Mass：

479.06

DSSTox ID：

DTXSID0048846

ATC Code：

N - Nervous system

Characteristics

PSA：

38.8

XLogP3：

5.01280

Density：

1.26 g/cm³

Boiling Point：

680.2ºC at 760 mmHg

Flash Point：

365.2ºC

Refractive Index：

1.666

Drug Information

MeSH Entry Terms：

3-chloro-5-(3-(2-oxo-1,2,3,5,6,7,8,8a-octahydroimidazo(1,2-a)pyridine-3-spiro-4'-piperidino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine

Mosapramine Use and Manufacturing

Dibenzoazepine antipsychotic drugs can block dopamine D2 receptors and serotonin H2 receptors. Used to treat schizophrenia.

Computed Properties

Molecular Weight:479.1
XLogP3:5.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:478.2499394
Monoisotopic Mass:478.2499394
Topological Polar Surface Area:38.8
Heavy Atom Count:34
Complexity:725
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes