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2,4-Diamino-6-hydroxypyrimidine

2,4-Diamino-6-hydroxypyrimidine structure

CAS No:
56-06-4
Formula:
C4H6N4O
Chemical Name:
2,4-Diamino-6-hydroxypyrimidine
Synonyms:
4(3H)-Pyrimidinone,2,6-diamino-;4(1H)-Pyrimidinone,2,6-diamino-;2,6-Diamino-4(3H)-pyrimidinone;2,4-Diamino-6-hydroxypyrimidine;2,6-Diamino-4-pyrimidinol;2,6-Diamino-4-hydroxypyrimidine;6-Hydroxy-2,4-pyrimidinediamine;2,6-Diamino-4(1H)-pyrimidinone;6-Aminoisocytosine;2,6-Diaminopyrimidin-4-one;2,4-Diamino-6-pyrimidinone;NSC 44914;NSC 680818;NSC 9302;2,6-Diamino-3,4-dihydropyrimidin-4-one;6-Hydroxy-2,4-diaminopyrimidine;2,6-Diamino-3H-pyrimidin-4-one;4-Hydroxypyrimidine-2,6-diamine;2,6-Diamino-1,4-dihydropyrimidin-4-one;2,6-Diamino-1H-pyrimidin-4-one;40306-60-3;41982-31-4;863767-89-9
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis), blocks BH4 synthesis and suppresses NO production[1].

2,4-Diamino-6-hydroxypyrimidine Basic Attributes

Molecular Weight：

126.12

Exact Mass：

126.12

BRN：

125006

EC Number：

200-254-4

HScode：

2933599090

Characteristics

PSA：

93.5

XLogP3：

-1.8

Appearance：

White to cream Fine Crystalline Powder

Density：

1.6±0.1 g/cm3

Melting Point：

286 °C (decomp)

Boiling Point：

524.0±53.0 °C at 760 mmHg

Flash Point：

270.7±30.9 °C

Refractive Index：

1.770

Storage Conditions：

Desiccate at +4°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

22-24/25-36-26

Marks：

Hazard note：

Irritant

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

2,4-Diamino-6-hydroxypyrimidine Use and Manufacturing

2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC50 for inhibition of BH4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.[Cayman Chemical]

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Guide of 2,4-Diamino-6-hydroxypyrimidine

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Recommended Suppliers
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2,4-Diamino-6-hydroxypyrimidine

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