2,4-Diamino-6-hydroxypyrimidine
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2,4-Diamino-6-hydroxypyrimidine
structure -
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CAS No:
56-06-4
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Formula:
C4H6N4O
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Chemical Name:
2,4-Diamino-6-hydroxypyrimidine
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Synonyms:
4(3H)-Pyrimidinone,2,6-diamino-;4(1H)-Pyrimidinone,2,6-diamino-;2,6-Diamino-4(3H)-pyrimidinone;2,4-Diamino-6-hydroxypyrimidine;2,6-Diamino-4-pyrimidinol;2,6-Diamino-4-hydroxypyrimidine;6-Hydroxy-2,4-pyrimidinediamine;2,6-Diamino-4(1H)-pyrimidinone;6-Aminoisocytosine;2,6-Diaminopyrimidin-4-one;2,4-Diamino-6-pyrimidinone;NSC 44914;NSC 680818;NSC 9302;2,6-Diamino-3,4-dihydropyrimidin-4-one;6-Hydroxy-2,4-diaminopyrimidine;2,6-Diamino-3H-pyrimidin-4-one;4-Hydroxypyrimidine-2,6-diamine;2,6-Diamino-1,4-dihydropyrimidin-4-one;2,6-Diamino-1H-pyrimidin-4-one;40306-60-3;41982-31-4;863767-89-9
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CAS No:
Description
2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis), blocks BH4 synthesis and suppresses NO production[1].
Characteristics
93.5
-1.8
White to cream Fine Crystalline Powder
1.6±0.1 g/cm3
286 °C (decomp)
524.0±53.0 °C at 760 mmHg
270.7±30.9 °C
1.770
Desiccate at +4°C
Safety Information
NONH for all modes of transport
3
36/37/38
22-24/25-36-26
Xi
Irritant
Stable under normal temperatures and pressures.
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
2,4-Diamino-6-hydroxypyrimidine Use and Manufacturing
2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC50 for inhibition of BH4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.[Cayman Chemical]
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