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Levocabastine hydrochloride

Levocabastine hydrochloride structure

CAS No:
79547-78-7
Formula:
C26H29FN2O2.ClH
Chemical Name:
Levocabastine hydrochloride
Synonyms:
4-Piperidinecarboxylic acid,1-[cis-4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-,hydrochloride (1:1),(3S,4R)-;4-Piperidinecarboxylic acid,1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-,monohydrochloride,[3S-[1(cis),3α,4β]]-;4-Piperidinecarboxylic acid,1-[cis-4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-,monohydrochloride,(3S,4R)-;Levocabastine hydrochloride;Livostin
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

White or almost white powder.

Livostin (TN) is a member of piperidines.|Levocabastine Hydrochloride is the hydrochloride salt form of levocabastine, a synthetic piperidine derivative with antihistaminic properties. Levocabastine is a second generation histamine-1 receptor antagonist. When applied locally to the eye as a topical solution, this agent reduces itching, rhinorrhea, and symptoms of allergic rhinitis or conjunctivitis.

Levocabastine hydrochloride Basic Attributes

Molecular Weight：

456.98

Exact Mass：

456.19800

UNII：

124XMA6YEI

DSSTox ID：

DTXSID9045508

NCI Thesaurus Code：

C47582

HScode：

2933399090

Characteristics

PSA：

64.33000

XLogP3：

5.63398

Appearance：

white solid

Boiling Point：

611ºC at 760 mmHg

Flash Point：

323.3ºC

Water Solubility：

DMSO: ~10 mg/mL, soluble

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36

Marks：

Precautionary statement(s)：

P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (97.5%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 41 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment. (See all compounds classified as Histamine H1 Antagonists, Non-Sedating.)

MeSH Entry Terms：

1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-4-piperidinecarboxylic acid

Levocabastine hydrochloride Use and Manufacturing

Uses

A histamine H1 receptor antagonist

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:457.0
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:456.1979841
Monoisotopic Mass:456.1979841
Topological Polar Surface Area:64.3
Heavy Atom Count:32
Complexity:681
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Levocabastine hydrochloride is a potent, long-acting, highly selective histamine H1 receptor antagonist. When applied topically to the nose, it takes effect almost immediately, eliminating the typical symptoms of allergic rhinitis (sneezing, itchy nose, runny nose), and the effect can last for several hours.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Levocabastine hydrochloride nasal spray
Ingredients	The main ingredient of this product is: Levocabastine hydrochloride.
Indication	Not yet clear.
Specifications	10 ml: 5 mg

Levocabastine hydrochloride nasal spray
Ingredients	Levocabastine hydrochloride.
Indication	1. There are no reports of interactions between this product and alcohol or any other drugs in clinical trials. In a specially designed psychoactive study, no interaction with diazepam was found, but a slight interaction with alcohol cannot be ruled out. 2. If used with other drugs at the same time, drug interactions may occur. Please consult a physician or pharmacist for details.
Specifications	10ml: 5mg*100 presses

Levocabastine hydrochloride nasal spray
Ingredients	Levocabastine hydrochloride.
Indication	1. There are no reports of interactions between this product and alcohol or any other drugs in clinical trials. In a specially designed psychoactive study, no interaction with diazepam was found, but a slight interaction with alcohol cannot be ruled out. 2. If used with other drugs at the same time, drug interactions may occur. Please consult a physician or pharmacist for details.
Specifications	10 ml: 5 mg

See More Related Drugs

Registered Holders

Guangzhou Tosun Pharmaceutical Ltd

China
Active
JANSSEN PHARMACEUTICA NV

European Union
Active
KATSURA CHEMICAL CO., LTD.

European Union
Active

Recommended Suppliers of Levocabastine hydrochloride

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

(3S,4R)-Cabastine HCl

CAS No.: 79547-78-7

Content: 99.00%

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Guide of Levocabastine hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
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